Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

Lipidor Reports Positive Clinical Phase I/II Data in Psoriasis

Published: Thursday, August 29, 2013
Last Updated: Thursday, August 29, 2013
Bookmark and Share
Company is developing AKVANO®/calcipotriol for the treatment of psoriasis vulgaris.

Lipidor has announced positive results from a Phase I/IIa study investigating the efficacy and tolerability of its AKVANO®/calcipotriol spray formulation for the treatment of psoriasis vulgaris, the most common form of psoriasis. Karolinska Development owns 50% of Lipidor.

“The positive study results represents an important milestone for Lipidor in its efforts to develop a product with equivalent clinical efficacy compared to market leading calcipotriol-only topical treatments, and with superior cosmetic qualities and greater ease of use, thereby, improving compliance rates and patient quality of life”, concludes Anders Carlsson, CEO of Lipidor.

Various kinds of ointments, creams and lotions are commonly prescribed treatments for psoriasis, but they also show low compliance rates.

This is largely due to their greasiness and inability to absorb into the skin and therefore be present on the skin for a long time after application. This causes personal discomfort as well as staining of clothes.

Lipidor is developing AKVANO®/calcipotriol, a water-free spray formulation containing calcipotriol, a vitamin D derivative that is one of the cornerstones in the treatment of mild to moderate psoriasis vulgaris.

The AKVANO® technology enables efficient delivery of the pharmaceutical ingredient. After application the carrier compounds evaporates quickly, leaving a pleasant feeling on the skin and a cosmetically appealing result.

Data from the recently concluded Phase I/IIa clinical study in 24 psoriasis vulgaris patients revealed that the AKVANO®/calcipotriol spray formulation had clear and significant antipsoriatic effects compared to placebo, comparable to a marketed formulation of calcipotriol. This means that the primary objective of the trial was met.

In the study, the patients received 10 topical treatments over 12 days. No safety issues were noted in the study. Approximately 125 million patients suffer from psoriasis worldwide.

While the disease varies in its manifestation, psoriasis vulgaris that affects 80-90% of the patients typically causes plaques of rapid skin accumulation at certain areas of the skin.

One of the measures of disease severity is the body surface area covered by affected skin plaques or lesions, from distinctly localized to widespread. Psoriasis can cause itching and pain, scaling of skin and bleeding lesions.

Quality of life aspects, including self-consciousness and social withdrawal are important factors in the management of the disease including treatment compliance.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More Than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Dilaforette Initiates Phase II Clinical Trial with Sevuparin in SCD
A multi-center, double-blind, placebo-controlled study in patients experiencing vaso-occlusive crisis.
Wednesday, October 21, 2015
Dilafor Enters into a License and Partnership Agreement with Lee’s Pharmaceutical
Dilafor grants the right to manufacture, develop and commercialize tafoxiparin to Lee's Pharmaceutical.
Friday, February 21, 2014
Pergamum Announces Final Data from Phase I/II Study of LL-37
Phase I/II trial of LL-37 for treatment of patients with chronic leg ulcers.
Thursday, October 10, 2013
Pharmanest Meets All Efficacy and Safety End Points in Phase II Study of SHACT
Data show that SHACT is effective in reducing pain during IUD insertion.
Monday, August 05, 2013
Pergamum Reports Positive Data from Phase II Clinical Trial of PXL-01
Follow-up data from the Phase II clinical trial for prevention of post-surgical adhesions.
Thursday, June 27, 2013
First Patient Dosed in the Phase I/II Study of UC1010 for PMDD Patients
First patient has been dosed with UC1010 in a double-blind, multicenter study.
Monday, May 27, 2013
Pharmanest Initiates Phase I Trial with SHACT
Trial is expected to enroll 15 patients and the study will be conducted at the Karolinska University Hospital.
Monday, October 15, 2012
Pergamum Reports Top Line Phase II-data from the Clinical Trial of PXL-01
The final Phase II report is expected to be published in the third quarter 2012.
Monday, August 06, 2012
Pharmanest Initiates Phase II Study of SHACT
Goal of the study is to evaluate the effect of SHACT in connection with IUD insertion in women.
Tuesday, June 19, 2012
Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
How a Genetic Locus Protects Adult Blood-Forming Stem Cells
Mammalian imprinted Gtl2 protects adult hematopoietic stem cells by restricting metabolic activity in the cells' mitochondria.
Genetic Basis of Fatal Flu Side Effect Discovered
A group of people with fatal H1N1 flu died after their viral infections triggered a deadly hyperinflammatory disorder in susceptible individuals with gene mutations linked to the overactive immune response, according to a recent study.
New Tech Vastly Improves CRISPR/Cas9 Accuracy
A new CRISPR/Cas9 technology developed by scientists at UMass Medical School is precise enough to surgically edit DNA at nearly any genomic location, while avoiding potentially harmful off-target changes typically seen in standard CRISPR gene editing techniques.
The MaxSignal Colistin ELISA Test Kit from Bioo Scientific
Kit can help prevent the antibiotic apocalypse by keeping last resort drugs out of the food supply.
"Good" Mozzie Virus Might Hold Key to Fighting Human Disease
Australian scientists have discovered a new virus carried by one of the country’s most common pest mosquitoes.
Non-Disease Proteins Kill Brain Cells
Scientists at the forefront of cutting-edge research into neurodegenerative diseases such as Alzheimer’s and Parkinson’s have shown that the mere presence of protein aggregates may be as important as their form and identity in inducing cell death in brain tissue.
Closing the Loop on an HIV Escape Mechanism
Research team finds that protein motions regulate virus infectivity.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Potential Treatment for Life-Threatening Viral Infections Revealed
The findings point to new therapies for Dengue, West Nile and Ebola.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos