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Active Polyketides Isolated from Penicillium Herquei

Published: Thursday, August 29, 2013
Last Updated: Thursday, August 29, 2013
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This paper reports the isolation of six polyketides.

In this work we are reporting the isolation by classical methods of chromatography of six polyketides fromPenicillium herquei. The compounds citreorosein ( 1) , emodin ( 2) , janthinone ( 3) , citrinin ( 4) , citrinin H1 ( 5) and dicitrinol ( 6) were identified by spectral methods of 1D and 2D NMR and MS. Compounds 1, 2 and 3 were tested against promastigotes forms of Leishmania brasiliensis and 1 and 2 were also assayed against Escherichia coli, Pseudomonas aeruginosa and Bacillus subtilis and showed good activity.

This article was published online in Anais da Academia Brasileira Ciencias as is free to access.

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