Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Diabetes Drug May Reverse Alzheimer's and Enters Major Clinical Trial

Published: Tuesday, September 17, 2013
Last Updated: Tuesday, September 17, 2013
Bookmark and Share
A commonly prescribed diabetes drug could reverse memory loss and the build-up of plaques on the brain linked to Alzheimer's.

The research is published in Neuropharmacology. The findings come as the charity prepares the next phase of its Drug Discovery programme which aims to repurpose existing drugs as dementia treatments in as little as five to ten years.

Results from the study, led by Professor Christian Hölscher at Lancaster University, show that liraglutide might be able to reverse some of the damage caused by Alzheimer's disease in the later stages of the condition. Mice with late-stage Alzheimer's given the drug performed significantly better on an object recognition test and their brains showed a 30 per cent reduction in the build-up of toxic plaques.

Liraglutide is a member of a class of drugs known as a GLP-1 analogue. The drug is used to stimulate insulin production in diabetes, but research shows it can also pass through the blood brain barrier and have a protective effect on brain cells.

Alzheimer's Society's flagship Drug Discovery programme seeks to repurpose existing drugs for use in dementia. An earlier study of liraglutide funded by the charity showed promising results in mice with early stage Alzheimer's. This research now demonstrates the drug's potential as a treatment in the later stages of the condition. A major clinical trial led by Dr Paul Edison of Imperial College London and partly funded by Alzheimer's Society to test the effectiveness of the drug in people with Alzheimer's disease will also begin recruiting patients in the next few weeks.

Alzheimer's disease is the most common form of dementia. The condition is caused by diseases of the brain and is characterised by the slow death of brain cells. It is progressive, there are few effective treatments and as yet there is no cure. If successful in clinical trials liraglutide will be the first new dementia treatment in a decade.

Dr Doug Brown, Director of Research and Development at Alzheimer's Society said:

'Developing new drugs from scratch can take 20 years and hundreds of millions of pounds. We owe it to the 800,000 people with dementia in the UK to do everything we can to accelerate the process. Our focus on repurposing existing drugs as dementia treatments is an incredibly exciting way of bringing new treatments closer.

This exciting study suggests that one of these drugs can reverse the biological causes of Alzheimer's even in the late stages and demonstrates we're on the right track. We're now funding a major new trial to bring it closer to a position where it can be improving the lives of people with dementia.'


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More Than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Food Triggers Creation of Regulatory T Cells
IBS researchers document how normal diet establishes immune tolerance conditions in the small intestine.
Light Signals from Living Cells
Fluorescent protein markers delivered under high pressure.
Counting Cancer-busting Oxygen Molecules
Researchers from the Centre for Nanoscale BioPhotonics (CNBP), an Australian Research Centre of Excellence, have shown that nanoparticles used in combination with X-rays, are a viable method for killing cancer cells deep within the living body.
Therapeutic Approach Gives Hope for Multiple Myeloma
A new therapeutic approach tested by a team from Maisonneuve-Rosemont Hospital (CIUSSS-EST, Montreal) and the University of Montreal gives promising results for the treatment of multiple myeloma, a cancer of the bone marrow currently considered incurable with conventional chemotherapy and for which the average life expectancy is about 6 or 7 years.
Cellular 'Relief Valve'
A team led by scientists at The Scripps Research Institute (TSRI) has solved a long-standing mystery in cell biology by showing essentially how a key “relief-valve” in cells does its job.
Genomic Signature Shared by Five Types of Cancer
National Institutes of Health researchers have identified a striking signature in tumor DNA that occurs in five different types of cancer.
Protein Protects Against Flu in Mice
The engineered molecule doesn’t provoke inflammation and may hail a new class of antivirals.
Cat Stem Cell Therapy Gives Humans Hope
By the time Bob the cat came to the UC Davis veterinary hospital, he had used up most of his nine lives.
Crowdfunding the Fight Against Cancer
From budding social causes to groundbreaking businesses to the next big band, crowdfunding has helped connect countless worthy projects with like-minded people willing to support their efforts, even in small ways. But could crowdfunding help fight cancer?
Switch Lets Salmonella Fight, Evade Immune System
Researchers at the University of Illinois at Chicago have discovered a molecular regulator that allows salmonella bacteria to switch from actively causing disease to lurking in a chronic but asymptomatic state called a biofilm.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!