Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Pancreatic Stem Cells Isolated from Mice

Published: Tuesday, September 17, 2013
Last Updated: Tuesday, September 17, 2013
Bookmark and Share
Scientists have succeeded in growing stem cells that have the ability to develop into two different types of cells that make up a healthy pancreas.

The research team led by Dr. Hans Clevers of the Hubrecht Institute, The Netherlands, have isolated and grown stem cells from the pancreases of mice using a 3-D culture system previously developed by the scientists. The results, which are reported in The EMBO Journal, could eventually lead to ways to repair damaged insulin-producing beta cells or pancreatic duct cells.

Cell signalling molecules known as Wnts and a protein called Lgr5 are essential to produce adult stem cells that can be coaxed to grow and divide rapidly. However, these signaling pathways and molecules are inactive in the adult pancreas. “We have found a way to activate the Wnt pathway to produce an unlimited expansion of pancreatic stem cells isolated from mice,” Clevers said. “By changing the growth conditions we can select two different fates for the stem cells and generate large numbers of either hormone-producing beta cells or pancreatic duct cells.” He added: “This work is still at a very early stage and further experiments are needed before we can use such an approach for the culture of human cells but the results are a promising proof-of-concept.”

In the study, the pancreases of mice were altered in a way that makes duct cells proliferate and differentiate. Some cells in this new population were stem cells that were capable of self-renewal. The scientists were able to culture these cells to give rise to large numbers of pancreatic cells or tiny clumps of tissue referred to as organoids.

Therapeutic strategies for pancreatic disease have been hampered by a lack of cell culture systems that allow scientists to grow replacement tissue in a test tube or on a dish. Alternative approaches such as tissue transplantation are limited by the scarcity of donors and the possibility of tissue rejection. The new work offers access to an unlimited supply of pancreatic stem cells that would be beneficial for the development of new therapeutic interventions for pancreatic diseases like diabetes.

The next steps for the scientists will include further refinement of the cell culture methods developed in this study and investigation of ways to extend the approach to human pancreatic cells.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More Than 4,900+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Systems-Wide Genetic Investigation Of Blood Pressure Regulation
A genetic investigation of individuals in the Framingham Heart Study may prove useful to identify novel targets for the prevention or treatment of high blood pressure.
Friday, April 17, 2015
Endocrine Disruptors Impair Human Sperm Function
Endocrine disruptors may contribute to widespread fertility problems.
Tuesday, May 13, 2014
Small Non-coding RNAs Could be Warning Signs of Cancer
Results are published in EMBO reports.
Tuesday, February 18, 2014
Alternative Allocation of Science Funding Proposed
The method depends on a collective distribution of funding by the scientific community.
Wednesday, January 08, 2014
New Muscular Dystrophy Treatment Shows Promise in Early Study
A preclinical study has found that a new oral drug shows early promise for the treatment of muscular dystrophy.
Monday, September 09, 2013
Alzheimer’s Disease Protein Controls Movement in Mice
A protein well known for its role in Alzheimer’s disease controls spindle development in muscle and leads to impaired movement in mice when the protein is absent or treated with inhibitors.
Monday, June 24, 2013
How Disease Mutations Affect the Parkin Protein
Researchers at the MRC Laboratory of Molecular Biology have determined the crystal structure of Parkin, a protein found in cells that when mutated can lead to a hereditary form of Parkinson’s disease.
Monday, June 03, 2013
EMBO Announces 52 New Members for 2013
EMBO announced today that 52 outstanding researchers in the life sciences were newly elected to its membership.
Tuesday, May 21, 2013
Thijn Brummelkamp Receives the EMBO Gold Medal for 2013
The award acknowledges his outstanding work to accelerate the genetic analysis of human disease.
Wednesday, May 08, 2013
Scientists Discover New Diagnostic Markers for Kawasaki Disease
Proteins discovered in human urine offers new opportunities for the diagnosis, study and treatment of disease.
Friday, December 21, 2012
Cancer Stem Cells Isolated from Kidney Tumours
Scientists have isolated cancer stem cells that lead to the growth of Wilms’ tumours, a type of cancer typically found in the kidneys of young children.
Friday, December 14, 2012
EMBO, EMBC and the National Science Council of Taiwan Sign Cooperation Agreement
New ways of global scientific interaction have been created following a cooperation agreement between EMBO, the European Molecular Biology Conference (EMBC), and the National Science Council of Taiwan (NSC).
Thursday, November 29, 2012
Brain Neurons and Diet Influence Onset of Obesity and Diabetes in Mice
Mice lacking AgRP-neurons adapt poorly to a carbohydrate diet and their metabolism seems better suited for feeding on fat.
Friday, September 21, 2012
Danes, the wisest among Europeans
A survey of Danish citizens support using GM plants for production of pharmaceuticals
Friday, October 02, 2009
Scientific News
Shedding Light on HIV Vaccine Design
Broadly speaking - Mathematical modelling of host-pathogen coevolution sheds light on HIV vaccine design.
AACC 2016 Sees Clinical Chemistry Labs Drive Precision Medicine Offerings
Biomarker assays to enable precision medicine and risk assessment, mass spec-based tests designed for use in clinical labs large and small, and liquid biopsy technology captured the spotlight at the AACC annual meeting.
Automated Patch Clamping Trends
Learn more about current practices, preferences and metrics in ion channel drug screening using APC technology.
Lab-on-a-Stick: Miniaturised Clinical Testing For Fast Detection Of Antibiotic Resistance
A portable power-free test for the rapid detection of bacterial resistance to antibiotics has been developed by academics at Loughborough University and the University of Reading.
Genetic Ancestry of Cultivated Strawberry Unravelled
UNH scientists constructed a linkage map of the seven chromosomes of the diploid Fragaria iinumae, which allows them to fill in a piece of the genetic puzzle about the eight sets of chromosomes of the cultivated strawberry.
Progress In Vaccination Against Vespid Venom
Researchers at the Helmholtz Zentrum München and the Technical University Munich have presented a method which facilitates a personalised procedure for wasp allergy sufferers.
New Drug Target for Inflammatory Disorders
Penn study finds enigmatic molecules maintain equilibrium between fighting infection and inflammatory havoc.
Breast Cancer Cells Found To Switch Molecular Characteristics
Spontaneous interconversion between HER2-positive and HER2-negative states could contribute to progression, treatment resistance in breast cancer.
Mechanisms of Calcium Blockers
Researchers describe how the fundamental mode of action of two distinct chemical classes of calcium channel blockers differs.
Some Breast Cancer Patients With Low Genetic Risk Could Skip Chemotherapy
Genetic test can help predict survival and guide treatment options.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,900+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!