Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

High Throughput Screening of Cellular Bioenergetics

Published: Monday, September 23, 2013
Last Updated: Monday, September 23, 2013
Bookmark and Share
Screening of cellular bioenergetics by combining VIAFLO 96 with XF96 Extracellular Flux Analyzer.

INTEGRA has published a video demonstrating how its VIAFLO 96 handheld electronic pipette, used in conjunction with the Seahorse Bioscience XF96 Extracellular Flux Analyzer, provides high throughput screening of the cellular bioenergetics of multiple cell lines.

The measurement of cellular bioenergetics, the processes by which cells produce and consume energy, is fundamental to determining the growth, development, function and metabolism of cells.

The Seahorse Bioscience XF96 Extracellular Flux Analyzer enables the determination of the two major energy yielding pathways in cells, aerobic respiration and glycolysis, by simultaneously measuring the oxygen consumption rate (OCR) and the extracellular acidification rate (ECAR).

In laboratory tests the VIAFLO 96 is shown to simplify and significantly accelerate the loading of substrates, inhibitors and stimulators into the XF96 Extracellular Flux Assay Cartridges prior to making cellular bioenergetics measurements.

The VIAFLO 96 from INTEGRA is an internationally proven 96-channel handheld electronic pipette that enables fast, precise and easy simultaneous transfer of 96 samples.

The system has been designed such that 96 channel pipetting is as easy as single channel pipetting, consequently users are able to immediately benefit from the increased productivity delivered by their VIAFLO 96.

Using an XF96 Extracellular Flux Analyzer, investigators can measure the effects of up to four compounds on cellular metabolism, as well as determine the basal oxygen consumption and glycolysis rates.

The XF96 Extracellular Flux Analyzer can also generate data on respiratory capacity, mitochondrial function, fatty acid oxidation, glycolytic function, fatty acid, and amino acid metabolism, as well as ATP turnover and cell signaling in primary, adherent, tumor and suspension cells, islets, and isolated mitochondria.

This cellular information is of considerable importance to researchers developing new drugs for cancer, aging, and metabolic, cardiovascular, and neurodegenerative diseases.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More Than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

INTEGRA Biosciences Opens German Subsidiary
Company has also launched a new comprehensively featured German language website.
Friday, March 20, 2015
VIAFLO and INTEGRA Biosciences Exhibits High Performance Liquid Handling Products at LabAutomation 2009
The strategic US partners will demostrate the lightweight PIPETBOY serological pipettor and the DOSE IT peristaltic pump for high performance liquid handling.
Friday, January 09, 2009
CELLine 350 Cell Culture System Transforms the Effectiveness of its Small-Scale Antibody Production
The Institute for Molecular Medicine & Experimental Immunology uses the cell culture system, supplied by INTEGRA Biosciences.
Wednesday, November 22, 2006
Scientific News
Point of Care Diagnostics - A Cautious Revolution
Advances in molecular biology, coupled with the miniaturization and improved sensitivity of assays and devices in general, have enabled a new wave of point-of-care (POC) or “bedside” diagnostics.
Mass Spec Technology Drives Innovation Across the Biopharma Workflow
With greater resolving power, analytical speed, and accuracy, new mass spectrometry technology and techniques are infiltrating the biopharmaceuticals workflow.
One Step Closer to Precision Medicine for Chronic Lung Disease Sufferers
A study led by University of North Carolina at Chapel Hill, and National Jewish Health, has provided evidence of links between SNPs and known COPD blood protein biomarkers.
Researchers Find a Gap in the Brain’s Firewall Against Parkinson’s Disease
Researchers at NIH have found mouse study that identified a key player in the progression of the disorder.
Fat Cells That Amplify Nerve Signals in Response to Cold Also Affect Blood Sugar Metabolism
Researchers at UTSW have found that the protein connexin 43 forms cell-to-cell communication channels on the surface of emerging beige fat cells that amplify the signals from those few nerve fibers.
Drug to Treat Alcohol Use Disorder Shows Promise Among Drinkers With High Stress
The findings suggest that potential future studies with drugs targeting vasopressin blockade should focus on populations of people with AUD who also report high levels of stress.
C Dots Show Powerful Tumor Killing Effect
Nanoparticles known as Cornell dots, or C dots, have shown great promise as a therapeutic tool in the detection and treatment of cancer.
Faecal Bacteria Linked to Body Fat
Researchers at King’s College London have found a new link between the diversity of bacteria in human poo – known as the human faecal microbiome - and levels of abdominal body fat.
How Baby’s Genes Influence Birth Weight And Later Life Disease
The large-scale study could help to target new ways of preventing and treating these diseases.
Genes Underlying Dogs’ Social Ability Revealed
The social ability of dogs is affected by genes that also seem to influence human behaviour, according to a new study from Linköping University in Sweden.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!