Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Zetasizer Nano Used by Kiel University Researchers

Published: Tuesday, October 15, 2013
Last Updated: Tuesday, October 15, 2013
Bookmark and Share
Zetasizer Nano system used in studies on particulate vaccines for respiratory administration.

Researchers in the Department of Pharmaceutics and Biopharmaceutics at Kiel University in Germany, are using a Zetasizer Nano system from Malvern Instruments in their work on particulate vaccines formulations for administration via the respiratory tract.

Dr. Regina Scherließ leads the research group whose many recent publications include ‘PLGA nanoparticles for vaccine delivery to the respiratory tract and ‘Overcoming the challenges of nasal vaccines through intelligent particle engineering’.

“We formulate nanoparticles as antigen carriers and incorporate them into larger particles, known as nano-in-microparticles, or NiM, of a size feasible for deposition in the nose or lung,” explains Dr Scherließ.

Dr Scherließ continued, “We normally work with dry powder formulations, so the NiM will be dried, usually spray dried, at some point in the formulation process. As the particulate antigen carrier has to be taken up as a particle by the relevant immune cells, we mostly target dendritic cells and macrophages. Nanoparticle size is an important criterion for our formulations and we routinely measure this with the Zetasizer Nano.”

Particle size has to be measured directly after preparation and also upon redispersion of the NiM formulation. Redispersion often has to take place in physiological or cell culture media, and at this point the Zetasizer Nano is used to check for aggregates and particle size stability.

“We’ve also used the Zetasizer Nano for another project where we looked at stabilization of haemaglutinin during spray drying,” continued Dr Scherließ, “and as well in a project characterizing chitosan as an adjuvant. Here, we used the Zetasizer to determine the molecular weight of chitosans of different qualities.”

The Malvern Zetasizer range provides both exceptionally high performance and entry level systems that incorporate combinations of a particle size analyzer, zeta potential analyzer, molecular weight analyzer, protein mobility and microrheology measurements.

Particles and molecules from less than a nanometer in size to several microns can be analyzed by a range of variants to suit specific applications and budget.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More Than 4,900+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Partnership Between Malvern Instruments and RheoSense
Distribution agreement brings m-VROCi to industrial markets.
Tuesday, March 04, 2014
Component-Specific Particle Characterization of Pharmaceutical Cream
Publication shows use of Morphologi G3-ID for component-specific particle characterization of pharmaceutical cream.
Wednesday, January 29, 2014
Malvern Signs Exclusive Agreement with Affinity Biosensors
Agreement to distribute Affinity Biosensors’ Archimedes system extends Malvern Instruments’ biopharma solutions.
Tuesday, March 05, 2013
Malvern Team Presents Poster at ACS Colloids 2012 Symposium
Dr Ana Morfesis and Dr Ulf Nobbmann will present a poster on ‘Nanoparticle characterization by light scattering’.
Friday, May 18, 2012
Malvern takes ACHEMA Visitors from R&D Through to Product QC
Visitors to the Malvern Instruments stand at ACHEMA 2012 will see how the company’s range of complementary materials characterization technologies and instrumentation support the needs of manufacturing industry.
Wednesday, March 28, 2012
Malvern Instruments Opens New Multipurpose Facility in Houston
At 22,000 sq. ft. the new building is double the size of Malvern’s previous premises in Houston and houses state-of-the-art laboratories, product development, manufacturing and commercial operations.
Tuesday, March 27, 2012
Malvern Instruments and Postnova Analytics Co-operate
Both companies co-operate to deliver combined solution for characterizing challenging particulate systems.
Friday, February 17, 2012
Malvern Rheology Expert Contributes Chapter to Handbook of Nutraceuticals
The Handbook of Nutraceuticals Vol 2 is now available on-line as an e book.
Thursday, January 19, 2012
Extreme droplet sizing! Malvern Spraytec excels in zero gravity testing
ADA Technologies has confirmed that both NASA’s new space-bound fire extinguisher and the Spraytec laser diffraction spray particle size analyzer from Malvern Instruments function in zero gravity just as well as they do on Earth.
Tuesday, December 06, 2011
Malvern Scientists will lead Protein Characterization Workshop at PEGS Summit
Drs Kevin Mattison, Ulf Nobbmann and Jason Sanchez will lead a workshop at the 7th Annual PEGS.
Tuesday, September 13, 2011
Malvern Instruments and Purdue University Present Joint Symposium on Light Scattering Techniques for Nanoparticle Characterization
The symposium will take place on the Purdue Campus at West Lafayette, Indiana.
Thursday, September 08, 2011
Malvern Instruments and Paraytec Enter into Development and Technology Licensing Agreement
Paraytec’s ActiPix® technology being added to Malvern’s materials characterization portfolio.
Thursday, July 21, 2011
‘Two in a row’ as Malvern Instruments wins Queen’s Award for Second Year in Succession
Malvern Instruments is celebrating winning the Queen’s Award for Enterprise in the category of International Trade in two successive years.
Tuesday, May 17, 2011
Malvern Specialist Discusses Light Scattering Techniques at BioProcess International Europe 2011
Dr Hanna Jankevics will present a poster at the 7th annual BioProcess International Europe conference in Nice (France).
Thursday, April 14, 2011
Malvern Instruments Joins SoftComp Consortium and ESMI Project
Aim is to promote excellence in cross-disciplinary research and technique development in soft matter composites and complex fluids.
Monday, March 21, 2011
Scientific News
Breakthrough Flu Vaccine Inhibited by Pre-existing Antibodies
Universal truths – how existing antibodies are sabotaging the most promising new human flu vaccines.
Researchers Develop Software That Could Facilitate Drug Development
AptaTRACE can identify aptamers, potentially speed drug advancement.
Gene Therapy for Metabolic Liver Diseases
Researchers have tested gene therapy in pigs from hereditary tyrosinemia type 1, with corrected liver cells being transplanted into the diseased liver.
Zika Vaccine Candidates Show Promise
Two experimental vaccines have shown promise against a major viral strain responsible for the Brazilian Zika outbreak.
New Medication Shows Promise Against Liver Fibrosis in Animal Studies
Liver fibrosis is a gradual scarring of the liver that puts people at risk for progressive liver disease and liver failure.
Raw Eggs Deemed Safe to Eat
A report published today by the Advisory Committee on the Microbiological Safety of Food (ACMSF) into egg safety has shown a major reduction in the risk from salmonella in UK eggs.
Monitoring TTX Toxin in Shellfish
In a number of small studies, mussels and oysters from the eastern and northern part of the Oosterschelde in Holland were found to contain tetrodotoxin (TTX).
Gene Terapy for Muscle Wasting Developed
New gene therapy could save millions of people suffering from muscle wasting disease.
NIH Begins Yellow Fever Vaccine Trial
NIH has initiated an early-stage clinical trial of a vaccine to protect against yellow fever.
Gene-Editing 'Toolbox' Targets Multiple Genes Simultaneously
Researchers have designed a system that modifies, or edits, multiple genes in a genome at once while minimising unintentional effects.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,900+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!