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Exploring the Next Generation of Oligonucleotide Technologies at ASHG

Published: Wednesday, October 16, 2013
Last Updated: Tuesday, October 15, 2013
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IDT discusses custom enrichment strategies for advancing clinical research.

Integrated DNA Technologies (IDT) will be attending the American Society of Human Genetics (ASHG), in Boston (US), October 22-26.

Delegates of ASHG can also join Director of Product Development at IDT, Dr Scott Rose, for a presentation entitled “Building clinically relevant custom enrichment panels using IDT’s xGen® Lockdown® probes.”

The talk will take place in the Exhibition Theatre on October 23 at 10.15am and provides researchers with the chance to learn how they can improve the performance of their targeted enrichment protocols for clinical research.

Vastly improving the efficiency of next generation sequencing (NGS), target enrichment strategies are vital for making this powerful technology an accessible tool for clinical applications.

In-solution hybridization is the most effective approach, and IDT is at the forefront of developing novel oligonucleotide technologies for improving these protocols. As a novel alternative to array-synthesis platforms, xGen Lockdown probes offer unrivalled flexibility in the creation and modification of custom panels.

Enhancing the percentage of on-target capture when used in combination with libraries incorporating adaptors, IDT has also developed a new generation of proprietary modified blocking oligonucleotides.

The xGen Universal Blocking Oligos block nonspecific hybridization between the library and the adaptor sequence, and has been shown to improve “on-target capture” by 10-25% when using libraries made with TruSeq™ adaptors.

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