" "
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Harvard's Wyss Institute and AstraZeneca Announce Collaboration on Organs-on-Chips

Published: Wednesday, October 23, 2013
Last Updated: Wednesday, October 23, 2013
Bookmark and Share
Collaboration will leverage the Institute's Organs-on-Chips technologies to better predict safety of drugs in humans.

Human Organs-on-Chips are composed of a clear, flexible polymer about the size of a computer memory stick, and contain hollow microfluidic channels lined by living human cells -- allowing researchers to recreate the physiological and mechanical functions of the organ, and to observe what happens in real time. The goal is to provide more predictive and useful measures of the efficacy and safety of potential new drugs in humans -- which could represent an important step in reducing the need for traditional animal testing.

The collaboration with AstraZeneca will apply the Institute's advances in the development and validation of human Organs-on-Chips to develop new animal versions. These animal organs-on-chips will be tested alongside the human models to further understand the extent to which drug safety results in animals can predict how an investigational drug might impact humans. The testing of a potential new medicine on animals is a small but necessary step in bringing this medicine to market. Regulators require safety data from animal studies before giving the required approval to test a new medicine in humans. However, animal tests do not always accurately predict what will happen in humans.

"Comparing human and animal Organs-on-Chips is an exciting example of what we call 'predictive science,' in which we harness the power of technology to better understand how a medicine might ultimately impact patients and in some cases speed the delivery of innovative new medicines," said Stefan Platz, Vice President Drug Safety and Metabolism at AstraZeneca. "The Wyss Institute's technology could play a critical role in both improving patient safety and reducing the need for animal testing."

In February, Wyss Founding Director Don Ingber, M.D., Ph.D., who leads the Organs-on-Chips research program, received the prestigious 3Rs Prize from the UK's National Centre for the Replacement, Refinement and Reduction of Animals in Research for the lung-on-a-chip. In March the Society of Toxicology awarded him the Leading Edge in Basic Science Award for his "seminal scientific contributions and advances to understanding fundamental mechanisms of toxicity."

"This collaboration with AstraZeneca will help us to validate this approach as a potential alternative to animal testing by carrying out direct comparisons between organ chips containing cells from animals versus humans in organ-mimicking environments," said Ingber. "If successful, this effort should lead to ways to streamline the drug development process and more effectively predict safety of drugs and chemicals in humans."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More Than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Injectable 3-D Vaccines Could Fight Cancer
New findings show programmable biomaterials can be delivered using needle injection to induce an immune response and fight deadly diseases.
Wednesday, December 10, 2014
Programmable Glue Made of DNA Directs Tiny Gel Bricks to Self-Assemble
New method could help to reconnect injured organs or build functional human tissues from the ground up.
Thursday, September 12, 2013
Team Brings Novel Therapeutic Cancer Vaccine to Human Clinical Trials
Phase I clinical trial of an implantable vaccine has begun with the aim to treat melanoma, the most lethal form of skin cancer.
Thursday, September 12, 2013
Wyss Institute Awarded DARPA Contract to Further Advance Sepsis Therapeutic Device
DARPA gives award to further advance a blood-cleansing technology and help accelerate its translation to humans as a new type of sepsis therapy.
Thursday, March 28, 2013
Wyss Institute Models a Human Disease in an Organ-on-a-Chip
Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University have mimicked pulmonary edema in a microchip lined by living human cells, as reported today in the journal Science Translation Medicine.
Friday, November 09, 2012
Scientific News
Natural Protein Points to New Inflammation Treatment
Findings may offer insight to effective treatments for inflammatory diseases, such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
Genetic Cause of Rare Allergy
Institute has identified a genetic mutation responsible for a rare form of inherited hives induced by vibratory urticaria.
Battery Component Found to Harm Key Soil Microorganism
The material at the heart of the lithium ion batteries that power electric vehicles, laptop computers and smartphones has been shown to impair a key soil bacterium, according to new research.
Keeping Tumor Growth at Bay
Engineers at Washington University in St. Louis found a way to keep a cancerous tumor from growing by using nanoparticles of the main ingredient in common antacid tablets.
Natural Protein Points to New Inflammation Treatment
Findings may offer insight to effective treatments for inflammatory diseases, such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
Mitochondria Shown to Trigger Cell Ageing
An international team of scientists has for the first time shown that mitochondria, the batteries of the cells, are essential for ageing.
Cancer Cells Kill Off Healthy Neighbours
Cancer cells create space to grow by killing off surrounding healthy cells, according to UK researchers working with fruit flies.
Validating the Accuracy of CRISPR-Cas9
IBS Researchers create multiplex Digenome-seq to find errors in CRISPR-Cas9 processes.
Cancer Drug Target Visualized at Atomic Resolution
New study using cryo-electron microscopy shows how potential drugs could inhibit cancer.
Genetic Mechanism Behind Cancer-Causing Mutations
Researchers at Indiana University has identified a genetic mechanism that is likely to drive mutations that can lead to cancer.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!