Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

e-Therapeutics Starts Phase IIb Trial of ETS6103 in Major Depressive Disorder

Published: Thursday, October 31, 2013
Last Updated: Thursday, October 31, 2013
Bookmark and Share
Company expects to report the results of the trial in the first half of 2015.

e-Therapeutics plc has announced that it has started a randomized double-blind controlled phase IIb trial of ETS6103 in major depressive disorder.

The trial is evaluating ETS6103 as a second-line treatment for patients who have not responded adequately to first-line therapy with an SSRI (selective serotonin reuptake inhibitor).

It is being conducted by a group of primary care centres with a history of involvement in depression studies in the Glasgow area of Scotland.

Under the trial protocol, patients are enrolled prior to first-line treatment so that this can be standardized: every patient will receive the SSRI citalopram.

Those with significant depressive symptoms remaining after six weeks on citalopram will enter the randomized phase of the study, which compares two different doses of ETS6103 with amitriptyline, a widely available tricyclic antidepressant. Approximately 160 patients will be randomized.

The principal objective is to test whether the two ETS6103 regimens have antidepressant activity ’non-inferior’ to that of amitriptyline.

The primary measure of activity is the change in Montgomery–Åsberg Depression Rating Scale (MADRS) score between randomization and the end of treatment eight weeks later.

Safety and a variety of secondary efficacy variables will also be assessed. e-Therapeutics expects to report the results of the trial in the first half of 2015. If these are positive, the Company intends to seek a licensing deal for the drug.

Stephen Self, Development Director at e-Therapeutics, said: “A clear need exists for better treatments for patients who do not respond well to first-line anti-depressant therapies. We believe that ETS6103 has potential in this population and are working with an experienced group of clinicians to test this proposition in a randomized controlled trial.”


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More Than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

e-Therapeutics Reports Positive Interim Results from UK Phase Ia Trial of ETS2101
ETS2101 well tolerated at all six dose escalations with no serious adverse events attributed to the drug.
Tuesday, April 01, 2014
e-Therapeutics to Raise £40 Million
Company to advance lead cancer drug and exploit network pharmacology platform.
Tuesday, February 12, 2013
e-Therapeutics Starts Second Phase I Cancer Trial of ETS2101
Trial will enrol up to 45 patients with solid tumours at UK centres.
Friday, February 01, 2013
e-Therapeutics Provides Update on Progress of ETS2101 Cancer Trials
Interim data from the trials are expected in H1 2013.
Monday, December 24, 2012
e-Therapeutics’ ETS2101 Enters Phase I Clinical Trial in Brain Cancer
First findings are expected in late 2012.
Wednesday, June 20, 2012
e-Therapeutics’ Preliminary Results for the Year Ended 31 January 2012
Further drugs for infection and depression expected to enter trials in 2012.
Friday, June 15, 2012
Phase I Clinical Trials of Cancer Drug ETS2101 Approved by Regulators
Enrolment of patients into trials will begin shortly.
Thursday, March 29, 2012
e-Therapeutics Outlines Goals for 2012
Company announces presentation at biotech showcase conference.
Thursday, March 01, 2012
Prime Minister Opens e-Therapeutics’ Drug Discovery Centre near Oxford
David Cameron opens Company’s new drug discovery centre at Long Hanborough.
Monday, February 27, 2012
Celgene Executive Dr Rajesh Chopra Joins the Board of e-Therapeutics
Dr Chopra has extensive experience of all phases of drug development.
Monday, February 06, 2012
e-Therapeutics Appoints Daniel Elger as Chief Financial Officer
Dr Elger, 41, was previously the VP, Marketing & Communications at cancer drug developer Antisoma plc.
Thursday, July 21, 2011
Scientific News
Study Finds Brain Chemicals that Keep Wakefulness in Check
Researchers to develop new drugs that promote better sleep, or control hyperactivity in people with mania.
Sorting Through Cellular Statistics
Aaron Dinner, professor in chemistry, and his graduate student Herman Gudjonson are trying to read the manual of life, DNA, as part of the Dinner group’s research into bioinformatics—the application of statistics to biological research.
Playing 'Tag' with Pollution lets Scientists See Who's It
Using a climate model that can tag sources of soot from different global regions and can track where it lands on the Tibetan Plateau, researchers have determined which areas around the plateau contribute the most soot — and where.
Women’s Immune System Genes Operate Differently from Men’s
A new technology reveals that immune system genes switch on and off differently in women and men, and the source of that variation is not primarily in the DNA.
Long Telomeres Associated with Increased Lung Cancer Risk
Genetic predisposition for long telomeres predicts increased lung adenocarcinoma risk.
First Artificial Ribosome Designed
Researchers at the University of Illinois at Chicago and Northwestern University have engineered a tethered ribosome that works nearly as well as the authentic cellular component, or organelle, that produces all the proteins and enzymes within the cell.
High-Resolution 3D Images Reveal the Muscle Mitochondrial Power Grid
NIH mouse study overturns scientific ideas on energy distribution in muscle.
Expanding the Brain
A team of researchers has identified more than 40 new “imprinted” genes, in which either the maternal or paternal copy of a gene is expressed while the other is silenced.
Identifying a Key Growth Factor in Cell Proliferation
Researchers discover that aspartate is a limiter of cell proliferation.
Study Uncovers Target for Preventing Huntington’s Disease
Scientists from Cardiff University believe that a treatment to prevent or delay the symptoms of Huntington’s disease could now be much closer, following a major breakthrough.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!