Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Genetic Aberration Paves the Way for New Treatment of Cancer Disease

Published: Friday, November 08, 2013
Last Updated: Friday, November 08, 2013
Bookmark and Share
Research was recently published in Scandinavian Journal of Gastroenterology.

Researchers from Faculty of Health and Medical Sciences, University of Copenhagen, have characterized a genetic aberration on a group of colorectal cancer patients.

The discovery gives hope for a new and efficient treatment of colorectal cancer, which is a frequent and often fatal disease.

12-15 years of development and millions of dollars are typically the costs, when companies develop a new anti-cancer drug.

Therefore all short cuts to a treatment are welcome. Researchers at Department of Veterinary Disease Biology, University of Copenhagen, recently discovered such a potential short cut.

“Our new research shows, that we might be able to introduce a treatment faster and cheaper than usual in the development of cancer treatment, and we estimate that it will be efficient in around 10 per cent of patients with colorectal cancer," says MD and PhD student Sune Nygård, Department of Veterinary Disease Biology, University of Copenhagen.

Re-use of existing breast cancer treatment
In the new study the researchers have shown that around 10 per cent of colorectal cancer patients harbor an aberration in the gene called TOP2A in their cancer cells. These tumors could potentially benefit from treatment with a specific chemotherapeutic drug - a so-called “anti-TOP2A treatment”, which is already used in breast cancer patients with this gene aberration.

Clinical study begins
Approximately 600,000 patients die of colorectal cancer each year worldwide.

“If the first treatment doesn’t cure a patient with colorectal cancer, the possibilities of additional treatment are limited,” says Nils Brünner, MD, professor at University of Copenhagen. “Therefore it is very important to find a new, efficient treatment,” he adds.

The research group from the Department of Veterinary Disease Biology and professor Per Pfeiffer at Odense University Hospital have received funds from The Danish Cancer Society to initiate a clinical trial.

Here it will be tested, if patients with the TOP2A gene defect could benefit from the targeted anti-TOP2A treatment.

“It is unique to go from a discovery in the laboratory towards a treatment for cancer patients at this pace. This is only possible when researchers and doctors work closely together,” says Nils Brünner, University of Copenhagen.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More Than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Discovery Accelerates Targeted Cancer Treatment
In collaboration with international scientists, researchers from the University of Copenhagen have developed a method to help shorten the road to better cancer treatment.
Monday, May 11, 2015
World’s Tiniest Drug Cabinets could be Attached to Cancerous Cells for Long Term Treatment
Reservoirs of pharmaceuticals could be manufactured to bind specifically to infected tissue such as cancer cells for slow, concentrated delivery of drug treatments.
Wednesday, January 15, 2014
Great Potential for Faster Diagnoses with New Method
The more accurately we can diagnose a disease, the greater the chance that the patient will survive.
Monday, October 21, 2013
New Bio Bank to Resolve Legal and Ethical Issues
When researchers collect human tissue in a so-called bio bank, the purpose is usually to learn about various diseases and improve curing of them.
Tuesday, October 15, 2013
New Protein Knowledge Offers Hope for Better Cancer Treatment
Researchers have developed a sophisticated method for identifying modified proteins that affect a cell's ability to repair DNA damage.
Friday, September 20, 2013
EU Funding for Clinical Trials of a Placental Malaria Vaccine
PlacMalVac project has received an FP7 EU grant.
Tuesday, March 05, 2013
Protein Paves the Way for Correct Stem Cell Differentiation
Research from BRIC, University of Copenhagen, has identified a crucial role of the molecule Fbxl10 in differentiation of embryonic stem cells.
Monday, February 11, 2013
Discovering the Secrets of Tumour Growth
Scientists have identified a compound that blocks the expression of a protein without which certain tumours cannot grow.
Monday, January 28, 2013
Grants Attract Top Researchers to Copenhagen
Two international leading researchers have each been awarded a Novo Nordisk Foundation Laureate Research Grant of DKK 40 million (€ 5.36 million).
Monday, January 28, 2013
Stem Cells Develop Best in 3D
Scientists from The Danish Stem Cell Center (DanStem) at the University of Copenhagen are contributing important knowledge about how stem cells develop best into insulin-producing cells.
Monday, November 26, 2012
Reconsidering Cancer's Bad Guy
Researchers at the University of Copenhagen have found that a protein, known for causing cancer cells to spread around the body, is also one of the molecules that trigger repair processes in the brain.
Tuesday, November 20, 2012
Waking the Dead - Scientists Reconstruct the Nuclear Genome of an Extinct Human Being
The discovery improves our understanding of heredity and the disease risk passed down from our ancestors, Copenhagen scientists say.
Monday, February 15, 2010
Isolation of a new Gene Family Essential for Early Development
Researchers have identified a new gene family essential for embryonic development that may contribute to the understanding of the development of cancer.
Thursday, August 23, 2007
University of Copenhagen Wins Novo Nordisk Grant to Build Proteomics Center
The University of Copenhagen in Denmark plans to use a KRO 600 million grant from the Novo Nordisk Foundation to build a protein research center.
Monday, May 07, 2007
Scientific News
The Changing Tides of the In Vitro Diagnostics Market
With the increasing focus in personalized medicine, diagnostics plays a crucial role in patient monitoring.
LaVision BioTec Reports on the Neuro Research on the Human Brain After Trauma
Company reports on the work of Dr Ali Ertürk from the Institute for Stroke and Dementia Research at LMU Munich.
NIH Study Shows No Benefit of Omega-3 Supplements for Cognitive Decline
Research was published in the Journal of the American Medical Association.
Less May Be More in Slowing Cholera Epidemics
Mathematical model shows more cases may be prevented and more lives saved when using one dose of cholera vaccine instead of recommended two doses.
Investigating the Vape
Expert independent review concludes that e-cigarettes have potential to help smokers quit.
NIH Launches Human RSV Study
Study aims to understand infection in healthy adults to aid development of RSV medicines, vaccines.
Researchers Discover Synthesis of a New Nanomaterial
Interdisciplinary team creates biocomposite for first time using physiological conditions.
Poor Survival Rates in Leukemia Linked to Persistent Genetic Mutations
For patients with an often-deadly form of leukemia, new research suggests that lingering cancer-related mutations – detected after initial treatment with chemotherapy – are associated with an increased risk of relapse and poor survival.
Flu Remedies Help Combat E. coli Bacteria
Physiologists from the University of Zurich have now discovered why the intestinal bacterium Escherichia coli (E. coli) multiplies heavily and has an inflammatory effect.
Marijuana Genome Unraveled
A study by Canadian researchers is providing a clearer picture of the evolutionary history and genetic organization of cannabis, a step that could have agricultural, medical and legal implications for this valuable crop.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!