Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

Researchers Engineer Breakthrough for Biofuel Production

Published: Monday, November 25, 2013
Last Updated: Monday, November 25, 2013
Bookmark and Share
Prospects for economic and sustainable fuel alternative enhanced with discovery.

Researchers at Scripps Institution of Oceanography at UC San Diego have developed a method for greatly enhancing biofuel production in tiny marine algae.

As reported in this week’s online edition of the Proceedings of the National Academy of Sciences, Scripps graduate student Emily Trentacoste led the development of a method to genetically engineer a key growth component in biofuel production.

In the quest to loosen humanity’s dependence on traditional fossil fuel consumption, and with it rising concentrations of carbon dioxide and their damaging impacts on the environment, finding economically viable fuels from biological sources has been elusive.

A significant roadblock in algal biofuel research surrounds the production of lipid oils, the fat molecules that store energy that can be produced for fuel. A catch-22 has stymied economically efficient biofuel production because algae mainly produce the desired lipid oils when they are starved for nutrients. Yet if they are limited in nutrients, they don’t grow well. With a robust diet algae grow well, but they produce carbohydrates instead of the desired lipids for fuel.

In a significant leap forward that clears the lipid production hurdle, Trentacoste and her colleagues used a data set of genetic expression (called “transcriptomics” in laboratories) to target a specific enzyme inside a group of microscopic algae known as diatoms (Thalassiosira pseudonana). By metabolically engineering a “knock-down” of fat-reducing enzymes called lipases, the researchers were able to increase lipids without compromising growth. The genetically altered strains they developed, the researchers say, could be produced broadly in other species.

“These results demonstrate that targeted metabolic manipulations can be used to increase accumulation of fuel-relevant molecules.… with no negative effects on growth,” said Trentacoste. “We have shown that engineering this pathway is a unique and practical approach for increasing lipid yields.”

“Scientifically this is a huge achievement,” said Mark Hildebrand, a marine biology professor at Scripps and a coauthor of the study. “Five years ago people said you would never be able to get more lipids without affecting growth negatively. This paper shows that there isn’t an intrinsic barrier and gives us hope of more new things that we can try—it opens the door to a lot more work to be done.”

In addition to lowering the cost of biofuel production by increasing lipid content, the new method has led to advances in the speed of algal biofuel crop production due to the efficient screening process used in the new study.

“Maintaining high growth rates and high biomass accumulation is imperative for algal biofuel production on large economic scales,” the authors note in the paper.

“It seems especially fitting that Scripps-UC San Diego is displaying so much leadership in the field of sustainable biofuels from algae, for instance with the California Center for Algae Biotechnology starting here, given the history of the institution playing such a pivotal role in climate change research,” said paper coauthor William Gerwick, a distinguished professor of oceanography and pharmaceutical sciences
at Scripps’s Center for Marine Biotechnology and Biomedicine
and UC San Diego’s Skaggs School of Pharmacy and Pharmaceutical Sciences. “But these advances do not happen in isolation, and the current project is a great illustration of how different labs can collaborate to achieve greater advances than possible singly.”

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More Than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Microscopic Fish are 3D-Printed to do More Than Swim
Researchers demonstrate a novel method to build microscopic robots with complex shapes and functionalities.
Thursday, August 27, 2015
New Method Makes Culture of Complex Tissue Possible in any Lab
Scientists at the University of California, San Diego have developed a new method for making scaffolds for culturing tissue in three-dimensional arrangements that mimic those in the body.
Friday, February 10, 2012
Genetic Abnormalities Identified in Pluripotent Stem Cell Lines
A multinational team of researchers led by stem cell scientists at the University of California, San Diego School of Medicine and Scripps Research Institute has documented specific genetic abnormalities that occur in human embryonic (hESC) and induced pluripotent stem cell (iPSC) lines.
Tuesday, January 11, 2011
Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
How a Genetic Locus Protects Adult Blood-Forming Stem Cells
Mammalian imprinted Gtl2 protects adult hematopoietic stem cells by restricting metabolic activity in the cells' mitochondria.
Genetic Basis of Fatal Flu Side Effect Discovered
A group of people with fatal H1N1 flu died after their viral infections triggered a deadly hyperinflammatory disorder in susceptible individuals with gene mutations linked to the overactive immune response, according to a recent study.
New Tech Vastly Improves CRISPR/Cas9 Accuracy
A new CRISPR/Cas9 technology developed by scientists at UMass Medical School is precise enough to surgically edit DNA at nearly any genomic location, while avoiding potentially harmful off-target changes typically seen in standard CRISPR gene editing techniques.
The MaxSignal Colistin ELISA Test Kit from Bioo Scientific
Kit can help prevent the antibiotic apocalypse by keeping last resort drugs out of the food supply.
"Good" Mozzie Virus Might Hold Key to Fighting Human Disease
Australian scientists have discovered a new virus carried by one of the country’s most common pest mosquitoes.
Non-Disease Proteins Kill Brain Cells
Scientists at the forefront of cutting-edge research into neurodegenerative diseases such as Alzheimer’s and Parkinson’s have shown that the mere presence of protein aggregates may be as important as their form and identity in inducing cell death in brain tissue.
Closing the Loop on an HIV Escape Mechanism
Research team finds that protein motions regulate virus infectivity.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Potential Treatment for Life-Threatening Viral Infections Revealed
The findings point to new therapies for Dengue, West Nile and Ebola.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos