Ion channels are pore-forming membrane proteins. Hundreds of different
types of ion channel have been identified in the membranes of all biological
cells. They are reliable and invaluable tools for safety assessment and are
available in various cellular backgrounds.
Ion channels are essential for life and play a fundamental role in
physiological and biological processes, nervous system, cells, drug
target/delivery etc. A multitude of diseases result from the disruption of
normal ion channel function. Disorders resulting from a mutation in the gene
encoding an ion channel or its regulatory proteins are called channelopathies.
Common channelopathies include cystic fibrosis, long QT syndrome and epilepsy.
Ion channels are also involved in non-genetic diseases, such as diarrhea, which
is mediated by toxicological effects on ion channel function.
Creative Biomart’s well-established technique
allows expression in cell lines at over a million molecules per cell surface
and allows in-depth studies of biophysical properties of ion channels as well
as functional studies on proteins.
channels products are
validated for gene, protein, structure, function, and pharmacology. And their performance
is characterized. The product lines include:
- 5-HT3 receptors
(proton-gated) ion channels
- Chloride channels
- Cyclic nucleotide-regulated
- Epithelial sodium
- GABAA receptors
- Inward rectifier
- Ionotropic purinergic
- Ligand-gated cation
- Transient Receptor
- Voltage-gated calcium
- Voltage-gated sodium
Creative Biomart offers the products to help you uncover the function of
these channels and elucidate their role in disease.