Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Researcher Alters how Ovarian Syndrome is Diagnosed

Published: Friday, December 06, 2013
Last Updated: Friday, December 06, 2013
Bookmark and Share
Having multiple ovarian follicles is the leading cause of infertility in America, yet we may be going about its diagnosis wrongly.

Reproductive physiologist Marla Lujan, assistant professor in nutritional sciences who studies the causes, diagnosis and treatment of polycystic ovary syndrome (PCOS), has found that the guidelines used to diagnose the disorder have not kept up with advancements in ultrasound technology.

Her analysis – reported in two studies co-authored by Jacob Christ ’13 and three other students in the May issue of Human Reproduction and the upcoming issue of Fertility and Sterility – may lead to a new set of protocols and diagnostic thresholds.

When ultrasound was first introduced as a key diagnostic tool for PCOS a decade ago, doctors were advised to count the number of follicles that are characteristically found in polycystic ovaries; more than 12 per ovary was considered the threshold, as per the work of French scientist Didier Dewailly.

But Lujan was finding that healthy women commonly had 12 follicles per ovary, with no other indication of PCOS, a multifaceted syndrome that can produce menstrual aberrations, lack of ovulation, high levels of masculinizing hormones and metabolic disorders.

She wondered if improved imaging equipment was leading to finer follicle detection and whether the threshold should be raised accordingly. Her study on 142 women – 82 with PCOS, 60 without – and a review of a decade’s worth of literature and case studies, led to her conclusion that the threshold should be 26 follicles per ovary.

“We are able to see many more follicles than ever before. The old recommendations were an artifact of old technology,” Lujan said.

Lujan’s new recommendation – now backed by Dewailly – will be presented to an international consortium as part of the Androgen Excess and PCOS Society’s recommendations for the revised definition and significance of polycystic ovarian morphology.

“We don’t know what effect it will have on the number of women being diagnosed with PCOS, which is on the rise,” Lujan said. “Because of PCOS’s association with obesity, I think the upward trend still exists, but the number of healthy women flagged with the syndrome should come down. That has many implications, including access to care.”

Lujan hopes the revised threshold will provide more reliable, nuanced data that will help not only patients and clinicians, but also researchers. PCOS patients seem to experience different mixes of symptoms, of varying severity, and Lujan studies it as a spectrum disorder, exploring whether risks, prognosis and treatments should differ accordingly.

“Right now PCOS patients are all thrown into the same bag,” Lujan said. “At least moving forward, we will have better metrics to make decisions on what the actual spectrum for PCOS is.”

In trying to understand the causes of PCOS, Lujan would also benefit from more data from the age of its onset: puberty. She hopes to begin studies on adolescents – both healthy and those suspected to be at risk – but that may require different diagnostic thresholds, which have yet to be developed.

“There is a real need to define numbers for adolescents and older women,” Lujan said.

Other co-authors on the papers, “Follicle Number, Not Assessments of the Ovarian Stroma, Represents the Best Ultrasonographic Marker of Polycystic Ovary Syndrome” and “Updated Ultrasound Criteria for Polycystic Ovary Syndrome: Reliable Thresholds for Elevated Follicle Population and Ovarian Volume,” are Eric Brooks ’10, Brittany Jarrett ’13, graduate student Amy Willis and research support specialist Heidi Vanden Brink.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More Than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

$1M NIH Grant to Refine PCR Based Cancer Test
Researchers at Cornell University, Weill Cornell Medicine, the University of California, San Francisco, and the Infectious Diseases Institute in Kampala, Uganda, recieve a four-year, $1 million grant to hone technology for a quick, in-the-field diagnosis of Kaposi's sarcoma — a cancer frequently related to HIV infections.
Friday, September 02, 2016
Vortex Ring Freezing Applications
Accidental lab discovery could aid cell delivery and cell-free protein production.
Monday, August 22, 2016
Measuring Chemistry on a Chip
Researchers developing chemical sensor chip for sample analysis in a lab or monitoring air and water quality in the field.
Thursday, August 18, 2016
Key to Chronic Fatigue Syndrome is in Your Gut, Not Head
Researchers report they have identified biological markers of the disease in gut bacteria and inflammatory microbial agents in the blood.
Wednesday, June 29, 2016
Pathogen Takes Control of Gypsy Moth Populations
A new fungal pathogen is killing gypsy moth caterpillars and crowding out communities of pathogens and parasites that previously destroyed these moth pests.
Tuesday, April 26, 2016
Eating Green Could be in Your Genes
Genetic variation uncovered that has evolved in populations that have historically favored vegetarian diets, such as in India, Africa and parts of East Asia.
Friday, April 01, 2016
$4.8M USAID Grant to Improve Food Security
To strengthen capacity to develop and disseminate genetically engineered eggplant in Bangladesh and the Philippines, the USAID has awarded Cornell a $4.8 million, three-year cooperative grant.
Friday, April 01, 2016
Proteins Seek, Attack, Destroy Tumor Cells in Bloodstream
Using white blood cells to ferry potent cancer-killing proteins through the bloodstream virtually eliminates metastatic prostate cancer in mice, Cornell researchers have confirmed.
Friday, January 15, 2016
Tumor-suppressing Gene Lends Insight to Cancer Treatment
Researchers have found that delicate replication process derails if a gene named PTEN has mutated or is absent.
Tuesday, July 14, 2015
Synthetic Immune Organ Produces Antibodies
Cornell engineers have created a functional, synthetic immune organ that produces antibodies and can be controlled in the lab, completely separate from a living organism.
Friday, June 12, 2015
On Planes, Savory Tomato Becomes Favored Flavor
Study shows the effect that airplane noise has on passengers' taste preferences.
Friday, May 15, 2015
$5.5M NSF Grant Aims to Improve Rice Crops with Genome Editing
Researchers to precisely target, cut, remove and replace DNA in a living cell to improve rice.
Friday, May 08, 2015
'Shield' Gives Tricky Proteins a New Identity
Solubilization of Integral Membrane Proteins with high Levels of Expression.
Saturday, April 11, 2015
DNA Safeguard May Be Key In Cancer Treatment
Cornell researchers have developed a new technique to understand the actions of key proteins required for cancer cells to proliferate.
Monday, March 09, 2015
A ‘STAR’ is Born: Engineers Devise Genetic 'On' Switch
A new “on” switch to control gene expression has been developed by Cornell scientists.
Tuesday, February 03, 2015
Scientific News
Point of Care Diagnostics - A Cautious Revolution
Advances in molecular biology, coupled with the miniaturization and improved sensitivity of assays and devices in general, have enabled a new wave of point-of-care (POC) or “bedside” diagnostics.
Mass Spec Technology Drives Innovation Across the Biopharma Workflow
With greater resolving power, analytical speed, and accuracy, new mass spectrometry technology and techniques are infiltrating the biopharmaceuticals workflow.
One Step Closer to Precision Medicine for Chronic Lung Disease Sufferers
A study led by University of North Carolina at Chapel Hill, and National Jewish Health, has provided evidence of links between SNPs and known COPD blood protein biomarkers.
Blood Pressure Drug May Boost Effectiveness of Lung Cancer Treatment
Researchers at Imperial College London have suggested that the blood pressure drug may make a type of lung cancer treatment more effective.
Insight into Eye Diseases
Scientists recreate zebrafish cell regeneration from retinal stem cells in mice.
New Discovery May Benefit Farmers Worldwide
Scientists have shown how a crop-microbe 'team' protect against fungal infection.
Antibodies Paving the Way to HIV Vaccine
Researchers uncover factors responsible for the formation of broadly neutralizing HIV antibodies in humans.
Designing Drugs with a Whole New Toolbox
Researchers develop methods to design small, targeted proteins with shapes not found in nature.
Protein Studies Discover Molecular Secrets
Two protein studies have mapped proteins that reveal the secrets to recycling carbon and healing cells.
Tapping Evolution to Improve Biotech Products
Researchers show how 'ancestral sequence reconstruction' can be used to guide engineering of a blood clotting protein.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!