Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

ClinMet Metabolomics Platform Offers Unique Insights into Diabetic Kidney Disease

Published: Friday, December 13, 2013
Last Updated: Friday, December 13, 2013
Bookmark and Share
Findings overturn previous belief regarding relationship of mitochondrial activity and diabetic complications.

Researchers from The University of California, San Diego School of Medicine have published new metabolomics research that uncovers a novel, characteristic and highly consistent biochemical signature in urine associated with diabetic kidney disease. The findings, which form a foundation of ClinMet’s proprietary Clinical Metabolomics platform, have implications for the identification of clinically useful biomarkers for kidney function and for sharpening drug development and clinical trials related to chronic kidney disease, as well as to diabetes, obesity and cardiovascular disease.

The new research, authored by U.C. San Diego professor and ClinMet scientific founder, Kumar Sharma, M.D., F.A.H.A (Director of the Center for Renal Translational Medicine, Division of Nephrology-Hypertension and the Institute of Metabolomic Medicine) and colleagues, appears online in the Journal of the American Society of Nephrology. ClinMet has an exclusive license to use this set of metabolites in drug development and other applications, based on patents filed by UC San Diego.

The researchers quantified 94 urine metabolites in subjects with diabetes (type 1 or type 2) and chronic kidney disease (CKD), subjects with diabetes but no kidney disease, and healthy controls. They found that 13 of the metabolites were significantly different in those with disease compared to healthy controls (p values between 10-3 to 10-18), and 12 of 13 remained highly significant when compared to patients with type 1 or type 2 diabetes and no CKD. Moreover, 12 of the 13 metabolites were linked to mitochondrial metabolism and suggested global suppression of mitochondrial activity in the subjects with CKD relative to healthy individuals. This conclusion is in sharp contrast to prevailing beliefs about excess mitochondrial activity having a causal relationship to diabetic complications. The conclusions based on the urine metabolomic studies were independently validated based on protein and DNA analysis, indicating reduced mitochondrial content in the kidneys of patients with diabetic kidney disease.

“It is clear from this study that urine- and plasma-based metabolomics can be a rich source of biomarkers for understanding and treating diabetic kidney disease and possibly for related cardiovascular complications,” said Dr. Sharma. “This approach also offers direct insights into biochemical pathways linked to kidney dysfunction.”

Power of Clinical Metabolomics
“Genomics can help predict overall disease risk or a patient’s potential response to a drug, but cannot capture the effects that changes in diet, environmental factors, or other illnesses have on disease progression or improvement,” said Yesh Subramanian, President, Chief Executive Officer and co-founder of ClinMet. “Clinical metabolomics, in contrast, lets us quickly see biochemically what is happening in specific disease pathways over time and in the context of other factors affecting a patient’s health, including drug therapy. This makes clinical metabolomics a highly actionable platform for translational research and drug development.”

“We see clinical metabolomics enabling our pharmaceutical and biotech customers to effectively implement precision medicine today,” Mr. Subramanian noted. “The ability to predict which patients are likely to better respond to specific treatments holds immense promise for sharpening Phase 2 and 3 clinical trials now, and for improving clinical medicine in the future.” 


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More Than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Liquid Biopsies: Miracle Diagnostic or Next New Fad?
Thanks to the development of highly specific gene-amplification and sequencing technologies liquid biopsies access more biomarkers relevant to more cancers than ever before.
Connectome Map More Than Doubles Human Cortex’s Known Regions
Researchers at NIH have developed software that automatically detects the “fingerprint” of each of these areas in an individual’s brain scans.
Discovered Through ‘Big Data’ Analysis
Researchers at the SBP have identified over 100 new genetic regions that affect the immune response to cancer.
Human Stem Cells to Rapidly Generate Bone, Heart Muscle
A new study shows that combining positive and negative signals can quickly and efficiently steer stem cells down complex developmental pathways to become specialized tissues that could be used in the clinic.
New Mechanism of Tuberculosis Infection
Researchers at UTSW Medical Center have identified a new way that tuberculosis bacteria get into the body, revealing a potential therapeutic angle to explore.
New Therapeutic Targets For Small Cell Lung Cancer Identified
Researchers at UTSW Medical Center have identified a protein termed ASCL1 that is essential to the development of small cell lung cancer and that, when deleted in the lungs of mice, prevents the cancer from forming.
Eliminating Doubt in Criminal Investigations
New ASU certificate to help curb error, misunderstanding in the quest for justice.
Determination of 13 Organic Toxicants in Human Blood
Researchers have utilised liquid-liquid extraction coupling HPLC-MS/MS to identify and quantify organic toxicants in human blood.
A Novel Cell Culture Model For Forensic Biology Experiments
Researchers have developed a new cell culture model which provides an efficient research tool in forensic biology.
Rhino DNA Bank Aids Anti-Poaching Fight
At the University of Pretoria's Veterinary Genetics Laboratory (VGL) at Onderstepoort, Dr Cindy Harper and her team have developed a ground-breaking technique to collect and catalogue DNA from rhinos and rhino horns.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!