Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

New Anti-GABAB1 Receptor Antibody from AbboMax

Published: Thursday, December 19, 2013
Last Updated: Thursday, December 19, 2013
Bookmark and Share
Recent progress in neuroscience research from the Company.

Neurotransmitters are chemical messengers that transmit and modulate signals from neurons to other cells of the brain and body across a synapse. When a neurotransmitter binds to its corresponding receptor, it activates or inhibits the receptor's associated pathway.

GABA, the most prevalent inhibitory neurotransmitter in the mammalian central nervous system, plays an essential role in regulating vital neurological functions. GABA’s natural function is to reduce the activity of the neurons to which it binds through GABA receptors (GABARs).

Regulation of both excitatory and inhibitory synaptic transmission is critical for proper nervous system function. GABARs are promising drug targets for a wide spectrum of psychiatric and neurological disorders. They are involved in sedative and anxiolytic activities.

Enhancement of GABA signaling has been demonstrated in patients with central nervous system hypersomnias. GABA-ergic disturbances are hallmark features of schizophrenia and other neuropsychiatric disorders.

GABA-ergic system has been associated consistently with atypicalities in autism and aggressive behavior. Modulators of the GABARs may be useful in the treatment of visual, sleep, and cognitive disorders.

GABARs have been associated with seizures and memory dysfunction when disrupted. The up-regulations of GABA in the brain may lead to an antiepileptic effect. The cerebellar cortex, the brain region responsible for motor coordination and learning expresses a high density of GABARs.

Repeated alcohol exposure during the third trimester of pregnancy increases expression of GABARs in cerebellar granule neurons and delays motor development in rats. Ethanol significantly reduces the brain metabolism, probably via action at specific GABARs. These receptors an important role in the neuroprotective effects of anthocyanins against ethanol.

Interestingly, increased expression of GABARs has been detected in several human cancer cells and tissues.

It was demonstrated that the absence of functional GABARs disturbs glucose homeostasis in mice.

AbboMax offers new anti-GABAB1 receptor polyclonal antibody as well as an extensive collection of neuroscience related antibodies.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More Than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

AbboMax Announces the Availability of new Methyl- Specific Antibodies for the Epigenetics Research
Company offers nine novel anti- histone H3 antibodies specific for a mono-, di-, or tri-methylated state of Lys4, Lys9, and Lys27.
Friday, October 22, 2010
Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
Revolutionary Technologies Developed to Improve Outcomes for Lung Cancer Patients
Breath test to detect lung cancer brings oxygen directly to the wound.
NIH Supports New Studies to Find Alzheimer’s Biomarkers in Down Syndrome
Initiative will track dementia onset, progress in Down syndrome volunteers.
Dementia Linked to Deficient DNA Repair
Mutant forms of breast cancer factor 1 (BRCA1) are associated with breast and ovarian cancers but according to new findings, in the brain the normal BRCA1 gene product may also be linked to Alzheimer’s disease.
Using Drug-Susceptible Parasites to Fight Drug Resistance
Researchers at the University of Georgia have developed a model for evaluating a potential new strategy in the fight against drug-resistant diseases.
Boosting Breast Cancer Treatment
To more efficiently treat breast cancer, scientists have been researching molecules that selectively bind to cancer cells and deliver a substance that can kill the tumor cells, for several years.
New Gene Map Reveals Cancer’s Achilles’ Heel
Team of researchers switches off almost 18,000 genes
New Discovery Sheds Light on Disease Risk
Gaps between genes interact to influence the risk of acquiring disease.
How Cells ‘Climb’ to Build Fruit Fly Tracheas
Mipp1 protein helps cells sprout “fingers” for gripping.
Research Finding Could Lead to Targeted Therapies for IBD
Findings published online in Cell Reports.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos