" "
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Anti-GABAB1 Receptor Antibody from AbboMax

Published: Thursday, December 19, 2013
Last Updated: Thursday, December 19, 2013
Bookmark and Share
Recent progress in neuroscience research from the Company.

Neurotransmitters are chemical messengers that transmit and modulate signals from neurons to other cells of the brain and body across a synapse. When a neurotransmitter binds to its corresponding receptor, it activates or inhibits the receptor's associated pathway.

GABA, the most prevalent inhibitory neurotransmitter in the mammalian central nervous system, plays an essential role in regulating vital neurological functions. GABA’s natural function is to reduce the activity of the neurons to which it binds through GABA receptors (GABARs).

Regulation of both excitatory and inhibitory synaptic transmission is critical for proper nervous system function. GABARs are promising drug targets for a wide spectrum of psychiatric and neurological disorders. They are involved in sedative and anxiolytic activities.

Enhancement of GABA signaling has been demonstrated in patients with central nervous system hypersomnias. GABA-ergic disturbances are hallmark features of schizophrenia and other neuropsychiatric disorders.

GABA-ergic system has been associated consistently with atypicalities in autism and aggressive behavior. Modulators of the GABARs may be useful in the treatment of visual, sleep, and cognitive disorders.

GABARs have been associated with seizures and memory dysfunction when disrupted. The up-regulations of GABA in the brain may lead to an antiepileptic effect. The cerebellar cortex, the brain region responsible for motor coordination and learning expresses a high density of GABARs.

Repeated alcohol exposure during the third trimester of pregnancy increases expression of GABARs in cerebellar granule neurons and delays motor development in rats. Ethanol significantly reduces the brain metabolism, probably via action at specific GABARs. These receptors an important role in the neuroprotective effects of anthocyanins against ethanol.

Interestingly, increased expression of GABARs has been detected in several human cancer cells and tissues.

It was demonstrated that the absence of functional GABARs disturbs glucose homeostasis in mice.

AbboMax offers new anti-GABAB1 receptor polyclonal antibody as well as an extensive collection of neuroscience related antibodies.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More Than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

AbboMax Announces the Availability of new Methyl- Specific Antibodies for the Epigenetics Research
Company offers nine novel anti- histone H3 antibodies specific for a mono-, di-, or tri-methylated state of Lys4, Lys9, and Lys27.
Friday, October 22, 2010
Scientific News
Retractable Protein Nanoneedles
The ability to control the transfer of molecules through cellular membranes is an important function in synthetic biology; a new study from researchers at Harvard’s Wyss Institute for Biologically Inspired Engineering and Harvard Medical School (HMS) introduces a novel mechanical method for controlling release of molecules inside cells.
Leukemia’s Surroundings Key to its Growth
Researchers at The University of Texas at Austin have discovered that a type of cancer found primarily in children can grow only when signaled to do so by other nearby cells that are noncancerous.
Common Cell Transformed into Master Heart Cell
By genetically reprogramming the most common type of cell in mammalian connective tissue, researchers at the University of Wisconsin—Madison have generated master heart cells — primitive progenitors that form the developing heart.
‘Smelling’ Prostate Cancer
A research team from the University of Liverpool and the University of the West of England (UWE Bristol) has reached an important milestone towards creating a urine diagnostic test for prostate cancer that could mean that invasive diagnostic procedures that men currently undergo eventually become a thing of the past.
Genetic Mutation that Prevents Diabetes Complications
The most significant complications of diabetes include diabetic retinal disease, or retinopathy, and diabetic kidney disease, or nephropathy. Both involve damaged capillaries.
Criminal Justice Alcohol Program Linked to Decreased Mortality
Institute has announced that in the criminal justice alcohol program deaths dropped by 4.2 percent over six years.
Charting Kidney Cancer Metabolism
Changes in cell metabolism are increasingly recognized as an important way tumors develop and progress, yet these changes are hard to measure and interpret. A new tool designed by MSK scientists allows users to identify metabolic changes in kidney cancer tumors that may one day be targets for therapy.
Improving Regenerative Medicine
Lab-created stem cells may lack key characteristics, UCLA research finds.
Tick Genome Reveals Secrets of a Successful Bloodsucker
NIH has announced that decipher the genome of the blacklegged tick which could lead to new tick control methods.
"Dark Side" of the Transcriptome
New approach to quantifying gene "read-outs" reveals important variations in protein synthesis and has implications for understanding neurodegenerative diseases.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!