Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

Novel Cancer Cell DNA Damage Repair Mechanism

Published: Monday, December 23, 2013
Last Updated: Monday, December 23, 2013
Bookmark and Share
Findings result from application of the cell microarray screening method developed at VTT.

Cancer cells have an exceptional ability to repair damage to their DNA caused during uncontrolled cell division. Scientists have now unveiled a novel piece of the puzzle of cancer cell DNA repair mechanisms that explain the mechanistic changes in the genetic code of cancer cells.

Research with a material impact on cancer drug development was published in Science magazine on 5 December 2013.

The new findings explain partially why cancer cells, unlike normal cells, fail to die as a result of DNA damaging insults, and how this mechanism causes new genetic mutations in cancer cells. This new information directly benefits cancer research.

Now that scientists understand the repair mechanism, they are better equipped to develop drug therapies that specifically target cancerous cells.

The discovered DNA repair mechanism has previously not been described in human or mammalian cells. Cancer cells use the mechanism to repair DNA damage resulting from uncontrolled DNA replication forced by activated oncogenes.

The genes that participate in the DNA repair mechanism were discovered by Juha Rantala, Senior Scientist at VTT, and Thanos Halazonetis, Coordinator of the EU-funded GENICA (Genomic instability in cancer and pre-cancer) project, with the cell microchip screening method developed by Rantala in 2010. Based on gene silencing, the method allows a single microchip to screen the functions of tens of thousands of genes simultaneously.

This finding was preceded by years of research cooperation begun by Juha Rantala, Senior Scientist, and Professor Olli Kallioniemi (currently Director of the Finnish Institute of Molecular Medicine) from VTT and Professor Thanos Halazonetis (the University of Geneva). Thomas Helleday's research team at the Karolinska Institutet also participated in the research published in Science magazine.

The research was part of the EU's GENICA project aimed at discovering why the DNA damage sustained by cancer cells in the early stages of the disease fails to result in the programmed cell death associated with normal cells.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More Than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

VTT Printed a Morphine Test on Paper
Company use antibodies as morphine sensing molecules when creating this morphine test.
Saturday, April 18, 2015
European Research Project Aims at Early Diagnosis of Memory Disorders
800 patients to participate in testing new diagnostic procedures.
Thursday, March 20, 2014
International Prize for VTT's Allergy Vaccine Development Work
First vaccines to be ready for launch in about five years.
Monday, December 09, 2013
Powerful Enzymes Create Ethanol from Agricultural Harvest Waste
The mainly EU-funded DISCO project coordinated by VTT Technical Research Centre of Finland has developed powerful enzymes, which accelerate plant biomass conversion into sugars and further into products such as bioethanol.
Wednesday, January 09, 2013
Method Developed by VTT Targets Diagnosis of Early Alzheimer’s Disease
Half of patients could be diagnosed a year earlier than current clinical practice.
Friday, December 07, 2012
Food Industry’s High-Quality Co-Streams Used Effectively as Raw Material for New Products
Researchers develop new ways of using substantial co-streams from fish and oil plant processing.
Tuesday, August 14, 2012
VTT and GE Healthcare Developing Novel Biomarkers to Predict Alzheimer’s Disease
VTT and University of Eastern Finland scientists have discovered a serum biochemical signature.
Wednesday, June 27, 2012
Heparin-like Compounds Inhibit Breast Cancer Metastasis to Bone
Heparin-like compounds decreased bone destruction and tumor growth in bone.
Friday, June 15, 2012
VTT Identified Specific Bacteria which Precede Autoimmune Diabetes
New potential avenues for early disease detection and prevention.
Friday, October 28, 2011
Finnish Twin Study Yields New Information on How Fat Cells Cope With Obesity
The team used lipidomics to study the fat tissue biopsies among several sets of monozygotic twins.
Friday, July 29, 2011
One Step Closer to a Diagnostic Test for Schizophrenia
Scientists in Finland have revealed metabolic abnormalities that are associated with schizophrenia.
Thursday, April 14, 2011
VTT is Searching for New Drug Targets for Prostate Cancer in the New IMI PREDECT Project
PREDECT, one of IMI’s new projects, is developing novel models for breast, prostate and lung cancers.
Monday, April 04, 2011
New Potential Drug Targets Discovered for Preventing Prostate Cancer Cell Growth
Researchers from VTT Technical Research Centre of Finland and the University of Turku have discovered four metabolic enzymes regulating prostate cancer cell growth.
Friday, February 18, 2011
Zora Biosciences Commercializes VTT's Biotechnology Expertise
Zora will provide laboratory services to pharmaceutical industry in the area of metabolomics and associated bioinformatics.
Wednesday, June 27, 2007
VTT Develops Software Tool to Integrate and Analyze Complex Medical Data
The megNet® software can be applied in understanding complex relations in living organisms, and characterizing various diseases, such as cardiac diseases and diabetes.
Friday, April 27, 2007
Scientific News
Genetic Defences of Bacteria Don’t Aid Antibiotic Resistance
Genetic responses to the stresses caused by antibiotics don’t help bacteria to evolve a resistance to the medications, according to a new study by Oxford University researchers.
Detecting HIV Diagnostic Antibodies with DNA Nanomachines
New research may revolutionize the slow, cumbersome and expensive process of detecting the antibodies that can help with the diagnosis of infectious and auto-immune diseases such as rheumatoid arthritis and HIV.
Snapshot Turns T Cell Immunology on its Head
New research may have implications for 1 diabetes sufferers.
Tolerant Immune System Increases Cancer Risk
Researchers have found that individuals with high immunoCRIT ratios may have an increased risk of developing certain cancers.
Developing a Gel that Mimics Human Breast for Cancer Research
Scientists at the Universities of Manchester and Nottingham have been funded to develop a gel that will match many of the biological structures of human breast tissue, to advance cancer research and reduce animal testing.
Cell's Waste Disposal System Regulates Body Clock Proteins
New way to identify interacting proteins could identify potential drug targets.
New Approach to Treating Heparin-induced Blood Disorder
A potential treatment for a serious clotting condition that can strike patients who receive heparin to treat or prevent blood clots may lie within reach by elucidating the structure of the protein complex at its root.
Horse Illness Shares Signs of Human Disease
Horses with a rare nerve condition have similar signs of disease as people with conditions such as Alzheimer’s, a study has found.
How a Molecular Motor Untangles Protein
Diseases such as Alzheimer’s, Parkinson’s and prion diseases, all involve “tangled” proteins.
Compound Doubles Up On Cancer Detection
Researchers have found that tagging a pair of markers found almost exclusively on a common brain cancer yields a cancer signal that is both more obvious and more specific to cancer.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos