Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Scientists Solve a Sticky Problem

Published: Wednesday, January 08, 2014
Last Updated: Wednesday, January 08, 2014
Bookmark and Share
Researchers have determined the 3-dimensional structure of SabA, a protein that cause gastric disease.

Scientists have uncovered how an ulcer causing stomach bacteria, that has been linked to gastric cancer, sticks to and infects the lining of the stomach and gut.

Australian scientists have long had an interest in how the bacterium, Helicobacter pylori, causes ulcers and more rarely gastric cancer. Now, researchers led by Dr Terry Kwok and Professor James Whisstock, from Monash University’s Department of Biochemistry and Molecular Biology, have determined the 3-dimensional structure of a protein called SabA. SabA effectively acts as glue, sticking the bacteria to the lining the stomach, which can cause gastric disease.

Professor Whisstock said the findings could pave the way for potential new treatments for various gastric diseases.

“SabA is a type of protein known as an adhesin. As the name suggests, adhesins stick the bacteria to the cells lining the stomach. If we can stop SabA from working properly, then we may have a new approach for treating a range of different gastric diseases,” Professor Whisstock said.

The Monash University researchers pinpointed the part of SabA that is important for its stickiness, and they are now working to develop specific drugs that stop the protein from working properly.

Dr Kwok said infection with bacteria helicobacter pylori is the cause of most stomach and small intestine ulcers.

“Chronic Helicobacter pylori infection is an important problem, with re-occurring infections particularly difficult to treat, so there is great interest in developing new and specific drugs in this area,” Dr Kwok said.

The research was conducted at the Australian Synchrotron and recently published in the Journal of Biological Chemistry. The research was supported by the Australian Research Council and the National Health and Medical Research Council of Australia.

A team led by Professor Whisstock was granted $28 million last month from the Australian Research Council to establish the ARC Centre of Excellence in Advanced Molecular Imaging.

The centre will develop innovative imaging technologies to explore the immune system, leading to a better understanding of how the immune system functions.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More Than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Study Discovers Breast Cancer Metastasis Gene
The discovery paves the way for the development of therapies that target the early stages of breast cancer.
Wednesday, August 12, 2015
New Research Into Health Benefits Of Coffee
New research has brought us closer to being able to understand the health benefits of coffee.
Tuesday, May 05, 2015
Tiny Optical Antennas: A Nano Revolution
Newly developed tiny optical antennas, which function like spotlights at the nanoscale, offer the potential to measure food safety, identify air pollutants and even quickly diagnose and treat deadly diseases, like cancer.
Friday, March 13, 2015
New Approach Holds Promise for Dengue Fever
An exclusive partnering deal to develop Fenretinide for dengue fever.
Thursday, December 04, 2014
New Ways to Treat Solid Tumours
An international team of scientists has shown that an antibody against the protein EphA3, found in the micro-environment of solid cancers, has anti-tumour effects.
Friday, August 15, 2014
Scientific News
The Changing Tides of the In Vitro Diagnostics Market
With the increasing focus in personalized medicine, diagnostics plays a crucial role in patient monitoring.
LaVision BioTec Reports on the Neuro Research on the Human Brain After Trauma
Company reports on the work of Dr Ali Ertürk from the Institute for Stroke and Dementia Research at LMU Munich.
NIH Study Shows No Benefit of Omega-3 Supplements for Cognitive Decline
Research was published in the Journal of the American Medical Association.
Less May Be More in Slowing Cholera Epidemics
Mathematical model shows more cases may be prevented and more lives saved when using one dose of cholera vaccine instead of recommended two doses.
Investigating the Vape
Expert independent review concludes that e-cigarettes have potential to help smokers quit.
NIH Launches Human RSV Study
Study aims to understand infection in healthy adults to aid development of RSV medicines, vaccines.
Researchers Discover Synthesis of a New Nanomaterial
Interdisciplinary team creates biocomposite for first time using physiological conditions.
Poor Survival Rates in Leukemia Linked to Persistent Genetic Mutations
For patients with an often-deadly form of leukemia, new research suggests that lingering cancer-related mutations – detected after initial treatment with chemotherapy – are associated with an increased risk of relapse and poor survival.
Flu Remedies Help Combat E. coli Bacteria
Physiologists from the University of Zurich have now discovered why the intestinal bacterium Escherichia coli (E. coli) multiplies heavily and has an inflammatory effect.
Marijuana Genome Unraveled
A study by Canadian researchers is providing a clearer picture of the evolutionary history and genetic organization of cannabis, a step that could have agricultural, medical and legal implications for this valuable crop.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!