Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Scientists Solve a Sticky Problem

Published: Wednesday, January 08, 2014
Last Updated: Wednesday, January 08, 2014
Bookmark and Share
Researchers have determined the 3-dimensional structure of SabA, a protein that cause gastric disease.

Scientists have uncovered how an ulcer causing stomach bacteria, that has been linked to gastric cancer, sticks to and infects the lining of the stomach and gut.

Australian scientists have long had an interest in how the bacterium, Helicobacter pylori, causes ulcers and more rarely gastric cancer. Now, researchers led by Dr Terry Kwok and Professor James Whisstock, from Monash University’s Department of Biochemistry and Molecular Biology, have determined the 3-dimensional structure of a protein called SabA. SabA effectively acts as glue, sticking the bacteria to the lining the stomach, which can cause gastric disease.

Professor Whisstock said the findings could pave the way for potential new treatments for various gastric diseases.

“SabA is a type of protein known as an adhesin. As the name suggests, adhesins stick the bacteria to the cells lining the stomach. If we can stop SabA from working properly, then we may have a new approach for treating a range of different gastric diseases,” Professor Whisstock said.

The Monash University researchers pinpointed the part of SabA that is important for its stickiness, and they are now working to develop specific drugs that stop the protein from working properly.

Dr Kwok said infection with bacteria helicobacter pylori is the cause of most stomach and small intestine ulcers.

“Chronic Helicobacter pylori infection is an important problem, with re-occurring infections particularly difficult to treat, so there is great interest in developing new and specific drugs in this area,” Dr Kwok said.

The research was conducted at the Australian Synchrotron and recently published in the Journal of Biological Chemistry. The research was supported by the Australian Research Council and the National Health and Medical Research Council of Australia.

A team led by Professor Whisstock was granted $28 million last month from the Australian Research Council to establish the ARC Centre of Excellence in Advanced Molecular Imaging.

The centre will develop innovative imaging technologies to explore the immune system, leading to a better understanding of how the immune system functions.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More Than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Research Into Health Benefits Of Coffee
New research has brought us closer to being able to understand the health benefits of coffee.
Tuesday, May 05, 2015
Tiny Optical Antennas: A Nano Revolution
Newly developed tiny optical antennas, which function like spotlights at the nanoscale, offer the potential to measure food safety, identify air pollutants and even quickly diagnose and treat deadly diseases, like cancer.
Friday, March 13, 2015
New Approach Holds Promise for Dengue Fever
An exclusive partnering deal to develop Fenretinide for dengue fever.
Thursday, December 04, 2014
New Ways to Treat Solid Tumours
An international team of scientists has shown that an antibody against the protein EphA3, found in the micro-environment of solid cancers, has anti-tumour effects.
Friday, August 15, 2014
Scientific News
Liquid Biopsies: Utilization of Circulating Biomarkers for Minimally Invasive Diagnostics Development
Market Trends in Biofluid-based Liquid Biopsies: Deploying Circulating Biomarkers in the Clinic. Enal Razvi, Ph.D., Managing Director, Select Biosciences, Inc.
Lab-on-a-Chip Offers Promise for TB and Asthma Patients
A device to mix liquids using ultrasonics is the first and most difficult component in a miniaturized system for low-cost analysis of sputum from patients with pulmonary diseases such as tuberculosis and asthma.
Intracellular Microlasers Could Allow Precise Labeling of up to a Trillion Individual Cells
MGH investigators have induced structures incorporated within individual cells to produce laser light at wavelengths that differ based on the size, shape and composition of each microlaser, allowing precise labeling of individual cells.
Real-Time Imaging of Lung Lesions During Surgery
Targeted molecular agents cause lung adenocarcinomas to fluoresce during surgery, according to pilot report.
Watching a Tumour Grow in Real-Time
Researchers from the University of Freiburg have gained new insight into the phases of breast cancer growth.
Protein Related to Long Term Traumatic Brain Injury Complications Discovered
NIH-study shows protein found at higher levels in military members who have suffered multiple TBIs.
Childhood Cancer Cells Drain Immune System’s Batteries
Cancer cells in neuroblastoma contain a molecule that breaks down a key energy source for the body’s immune cells, leaving them too physically drained to fight the disease.
Urine Proteins Point to Early-Stage Pancreatic Cancer
A combination of three proteins found at high levels in urine can accurately detect early-stage pancreatic cancer, researchers at the BCI have shown.
Researcher Discovers Trigger of Deadly Melanoma
New research sheds light on the precise trigger that causes melanoma cancer cells to transform from non-invasive cells to invasive killer agents, pinpointing the precise place in the process where "traveling" cancer turns lethal.
New Vaccine For Chlamydia to Use Synthetic Biology
Prokarium Ltd, a biotechnology company developing transformational oral vaccines, have announced new funding from SynbiCITE, the UK’s Innovation and Knowledge Centre for Synthetic Biology.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!