Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Clues to How Bacteria Evade Antibiotics

Published: Friday, January 10, 2014
Last Updated: Friday, January 10, 2014
Bookmark and Share
Scientists have made an important advance in understanding how a subset of bacterial cells escape being killed by many antibiotics.

Cells become "persisters" by entering a state in which they stop replicating and are able to tolerate antibiotics. Unlike antibiotic resistance, which arises because of genetic mutations and is passed on to later generations, this tolerant phase is only temporary, but it may contribute to the later development of resistance.

In a new study in the journal Science, researchers from the MRC Centre for Molecular Bacteriology and Infection at Imperial College London have succeeded in visualising persister cells in infected tissues for the first time, and have identified signals that lead to their formation.

Virtually all bacterial species form subpopulations of persisters that are tolerant to many antibiotics. Persisters are likely to be a cause of many recurrent infections, but little is known about how they arise.

The team developed a method for tracking single cells using a fluorescent protein produced by the bacteria. They showed that Salmonella, which causes gastroenteritis and typhoid fever, forms large numbers of non-replicating persisters after being engulfed by immune cells called macrophages. By adopting this non-replicating mode, Salmonella survives antibiotic treatment and lingers in the host, accounting for its ability to cause recurrent infections.

The researchers also identified factors produced by human cells that trigger bacteria to become persisters.

One of the lead authors, Dr Sophie Helaine, said: "We rely on antibiotics to defend us against common bacterial infections like tuberculosis, cystitis, tonsillitis and typhoid, but a few cells can escape treatment by becoming persisters, which allows the infection to come back. This is a big problem in itself, but it also makes it more likely that antibiotic resistance will arise and spread.

"Now we know the molecular pathways and mechanisms that lead to persister formation during infection, we can work on screening for new drugs to coax them out of this state so that they become vulnerable to antibiotics." 

The other lead author, Professor David Holden, Director of the MRC Centre for Molecular Bacteriology and Infection at Imperial College London, said: "One of the most striking findings in this work is that conditions inside immune cells activate two different responses from Salmonella, causing some bacteria to replicate and others to enter a non-replicating persister state. Activating these two responses together is likely to be an important mechanism by which Salmonella survives during infection." 

The research was supported by an Imperial College London Junior Research Fellowship, the Wellcome Trust and the Medical Research Council.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More Than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Feeding Babies Egg and Peanut May Prevent Food Allergy
The new analysis pools all existing data, and suggests introducing egg and peanut at an early age may prevent the development of allergy.
Wednesday, September 21, 2016
Dengue Vaccine May Increase Risk of Severe Disease
The world's only licensed vaccine for dengue may worsen subsequent dengue infections if used in areas with low rates of dengue infection.
Friday, September 02, 2016
Breast Milk Sugar Protect Newborns Against Meningitis
Research suggests breat milk sugar can protect against Group B streptococcus, a leading cause of meningitis.
Thursday, September 01, 2016
Breast Milk Sugar May Protect Babies Against Deadly Infection
Researchers from Imperial College London find that a sugar found in some women’s breast milk may protect babies against Group B streptococcus.
Friday, August 26, 2016
MRSA – Just Add Salt
Scientists have discoved a new way to attack Staphylococcus aureus through salt content mechanisms
Friday, August 19, 2016
Flu Vaccine May Reduce Death Risk of Type 2 Diabetes
New research suggests that a new flu vaccine may reduce probability of type 2 diabetes patients being hospitalised with stroke and heart failure.
Tuesday, July 26, 2016
Zika Epidemic Likely to End Within Three Years
A team of scientists has predicted that the current Zika epidemic is likely to end within three years because there will be too few people left to infect.
Friday, July 15, 2016
Sound Waves May Hold Potential to Treat Twin Pregnancy Complications
Researchers at Imperial College London have found that the high energy sound waves could treat a potentially deadly complication that affects some twin pregnancies.
Friday, July 15, 2016
Viral hepatitis kills as Many as Malaria, TB or HIV/AIDS
Viral hepatitis is one of the leading killers across the globe, with a death toll that matches AIDS or tuberculosis.
Thursday, July 07, 2016
Supplement May Switch off Cravings for High-Calorie Foods
Researchers have found that inulin-propionate ester supplement curbs cravings for junk food.
Saturday, July 02, 2016
Dengue Virus Exposure May Amplify Zika Infection
Researchers at Imperial College London have found that the previous exposure to the dengue virus may increase the potency of Zika infection.
Friday, June 24, 2016
£14m EU Project To Aid Meningitis Diagnosis and Cut Antibiotic Use
An international team of doctors are aiming to develop a rapid test to allow medics to quickly identify bacterial infection in children.
Wednesday, June 22, 2016
New Bio-Glass Could Make it Possible to Re-Grow or Replace Cartilage
Researchers at Imperial College London have developed a material that can mimic cartilage and potentially encourage it to re-grow.
Wednesday, May 18, 2016
Gene Expression Controls Revealed
Researchers have modelled every atom in a key part of the process for switching on genes, revealing a whole new area for potential drug targets.
Tuesday, May 17, 2016
Crucial Reaction for Vision Revealed
Scientists have tracked the reaction of a protein responding to light, paving the way for a new understanding of life's essential reactions.
Monday, May 16, 2016
Scientific News
Mass Spec Technology Drives Innovation Across the Biopharma Workflow
With greater resolving power, analytical speed, and accuracy, new mass spectrometry technology and techniques are infiltrating the biopharmaceuticals workflow.
One Step Closer to Precision Medicine for Chronic Lung Disease Sufferers
A study led by University of North Carolina at Chapel Hill, and National Jewish Health, has provided evidence of links between SNPs and known COPD blood protein biomarkers.
Atmosphere Acidity Minimised to Preindustrial Levels
Sheet ice study shows acidic pollution of the atmosphere has now almost returned to preindustrial levels.
New Therapeutic Target for Crohn’s Disease
A promising new target for drugs that treat IBD has been identified along with a possible biomarker for IBD severity.
Culex Mosquitoes Do Not Transmit Zika
A study of the Culex species mosquito appears to show that the species does not transmit Zika virus.
Uncovering Water Bear Resilience
A protein identified in water bears can protect DNA of human cells from lethal doses of radiation damage.
“Sixth Sense” More Than a Feeling
NIH study of rare genetic disorder reveals importance of touch and body awareness.
Researchers Find Fungus-Fighting Compound
A compound has been identifed that blocks growth of a fungus responsible for lung infections and allergic reactions.
Analysing 10,000 Cells Simultaneously
New techniquethat traps 10,000 cells on a single chip has potential for cancer screening for individuals.
Potential of New Insect Control Traits in Agriculture
Researchers have discovered a protein that shows promise as an alternate corn rootworm control mechanism.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!