Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Scientists Design Protein to Prevent Prostate Cancer Cell Growth

Published: Thursday, January 30, 2014
Last Updated: Thursday, January 30, 2014
Bookmark and Share
New protein blocks the hormone receptors and consequently stops cancer cells from growing in the laboratory.

Researchers are creating a "designer" protein that could be effective at treating prostate cancer when other therapies fail.

In laboratory tests, the protein hindered the growth of cancer cells even in conditions where conventional therapies are ineffective.

The researchers, from Imperial College London and the University of Essex, hope to develop the protein into a therapeutic that could be trialled in patients within five years.

The findings are published in the journal Oncotarget.

Prostate cancer is the most common type of cancer in men. Around 37,000 UK men are diagnosed with the disease each year. Many prostate cancers develop very slowly, but in a small proportion of cases the cancer grows more quickly and spreads to other areas of the body, sometimes proving fatal.

Prostate cancers are only able to grow when they are exposed to male hormones such as testosterone. These hormones bring about their effects by binding to specific receptors. Many existing therapies target these receptors, yet after an average of two years the cancer becomes resistant to treatment. In this phase, hormones continue to drive the growth of cancer cells.

In this new study, the researchers have designed a new protein which blocks the hormone receptors and consequently stops prostate cancer cells from growing in the laboratory. The therapy was successful even in circumstances that lead to the failure of conventional treatments.

Dr Charlotte Bevan, senior author of the study, from the Department of Surgery and Cancer at Imperial College London said: "Eleven thousand men die from prostate cancer each year in the UK. Existing treatments are good at first but frequently fail after a couple of years. Once the cancer moves to the more aggressive stage, there are few therapies available.

"Our team is seeking to design a new therapy that will help patients once the other ones have failed. There is a lot of research supporting the idea that the androgen receptor continues to drive prostate cancer growth, so we have been investigating novel methods to block this pathway."

The team is designing a novel therapy by combining two separate proteins to create a hybrid. One half binds to the receptor, whilst the other half blocks the receptor's activity. The research demonstrates that both of these factors are important in blocking activity, and consequently the growth of the cancer.

"So far, the research has only been carried out in prostate cancer cells in the laboratory. These proof of principle experiments are really promising, but more work is needed before these therapies are ready for clinical trials" said Dr Greg Brooke, first author of the study, now at the School of Biological Sciences, University of Essex. "The next step is to continue research in cell models to refine the therapy into something that is specific, potent and easy to deliver.

"It's exciting to think that this research could offer new hope for men with advanced prostate cancer."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More Than 4,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Dengue Virus Exposure May Amplify Zika Infection
Researchers at Imperial College London have found that the previous exposure to the dengue virus may increase the potency of Zika infection.
Friday, June 24, 2016
£14m EU Project To Aid Meningitis Diagnosis and Cut Antibiotic Use
An international team of doctors are aiming to develop a rapid test to allow medics to quickly identify bacterial infection in children.
Wednesday, June 22, 2016
New Bio-Glass Could Make it Possible to Re-Grow or Replace Cartilage
Researchers at Imperial College London have developed a material that can mimic cartilage and potentially encourage it to re-grow.
Wednesday, May 18, 2016
Gene Expression Controls Revealed
Researchers have modelled every atom in a key part of the process for switching on genes, revealing a whole new area for potential drug targets.
Tuesday, May 17, 2016
Crucial Reaction for Vision Revealed
Scientists have tracked the reaction of a protein responding to light, paving the way for a new understanding of life's essential reactions.
Monday, May 16, 2016
Scans Reveal Babies of Mothers with Gestational Diabetes Have More Body Fat
Researchers at Imperial College London have found that the babies born to mothers with gestational diabetes have more body fat at two months of age compared to babies born to healthy mothers.
Saturday, May 14, 2016
The Brain on LSD: New Scans Show How the Drug Affects the Brain
Researchers at Imperial College London have visualised the effects of LSD on the brain.
Tuesday, April 12, 2016
Cost of Diabetes Hits 825 Billion Dollars a Year
The global cost of diabetes is now 825 billion dollars per year, according to the largest ever study of diabetes levels across the world.
Thursday, April 07, 2016
World's Obese Population Hits 640 Million
More than one in ten men and one in seven women across the globe are now obese, according to the world's biggest obesity study.
Friday, April 01, 2016
Interactive Maps Reveal Global Obesity
World’s obese population hits 640 million, according to largest ever study.
Friday, April 01, 2016
Switching Off Cancers' Ability to Spread
A key molecule in breast and lung cancer cells can help switch off the cancers' ability to spread around the body.
Tuesday, March 22, 2016
Bacterial Motors Unveiled
Nanoscopic 3D imaging has revealed how different bacteria have geared their tiny propeller motors for a wide range of swimming abilities.
Thursday, March 17, 2016
New App Advises and Reminds Pregnant Women About Vaccinations
Researchers at Imperial College London have developed a new app to guide and remind pregnant women about vaccines recommended during pregnancy.
Saturday, March 12, 2016
Infant Milk Formula Does Not Reduce Risk of Eczema and Allergies, Says New Study
Researchers at Imperial College London have found a type of baby formula does not reduce allergy risk - despite previous claims to the contrary.
Wednesday, March 09, 2016
Too Many Avoidable Errors in Patient Care, Says Report
Researchers at Imperial College London have launched the reports in which provide evidence on the current state of patient safety and how it could be improved the future.
Tuesday, March 08, 2016
Scientific News
Open Source Seed Initiative – A Welcome Boost to Global Crop Breeding
A team of plant breeders, farmers, non-profit agencies, seed advocates, and policymakers have created the Open Source Seed Initiative.
ASMS 2016: Targeting Mass Spectrometry Tools for the Masses
The expanding application range of MS in life sciences, food, energy, and health sciences research was highlighted at this year's ASMS meeting in San Antonio, Texas.
Benchtop Automation Trends
Gain a better understanding of current interest in and future deployment of benchtop automated systems.
Anthrax Proteins Might Help Treat Cancerous Tumors
Studies in mice reveal novel treatment regimen.
New Cancer Drug Target Found in Dual-Function Protein
Findings from a study from TSRI have shown that targeting a protein called GlyRS might help to halt cancer growth.
Key to Chronic Fatigue Syndrome is in Your Gut, Not Head
Researchers report they have identified biological markers of the disease in gut bacteria and inflammatory microbial agents in the blood.
HIV Structure Stabilized
Findings represent ‘big accomplishment’ in biomedical engineering and design.
Four Newly-Identified Genes Could Improve Rice
A Japanese research team have applied a method used in human genetic analysis to rice and rapidly discovered four new genes that are potentially significant for agriculture. These findings could influence crop breeding and help combat food shortages caused by a growing population.
New Cancer Drug Target in Dual-Function Protein
Scientists at The Scripps Research Institute (TSRI) have identified a protein that launches cancer growth and appears to contribute to higher mortality in breast cancer patients.
Antibodies To Dengue May Alter Course Of Zika Virus Infection
Scientists at Emory Vaccine Center, in collaboration with investigators from Thailand, have found that people infected with dengue virus develop antibodies that cross-react with Zika virus.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!