Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Scientists Design Protein to Prevent Prostate Cancer Cell Growth

Published: Thursday, January 30, 2014
Last Updated: Thursday, January 30, 2014
Bookmark and Share
New protein blocks the hormone receptors and consequently stops cancer cells from growing in the laboratory.

Researchers are creating a "designer" protein that could be effective at treating prostate cancer when other therapies fail.

In laboratory tests, the protein hindered the growth of cancer cells even in conditions where conventional therapies are ineffective.

The researchers, from Imperial College London and the University of Essex, hope to develop the protein into a therapeutic that could be trialled in patients within five years.

The findings are published in the journal Oncotarget.

Prostate cancer is the most common type of cancer in men. Around 37,000 UK men are diagnosed with the disease each year. Many prostate cancers develop very slowly, but in a small proportion of cases the cancer grows more quickly and spreads to other areas of the body, sometimes proving fatal.

Prostate cancers are only able to grow when they are exposed to male hormones such as testosterone. These hormones bring about their effects by binding to specific receptors. Many existing therapies target these receptors, yet after an average of two years the cancer becomes resistant to treatment. In this phase, hormones continue to drive the growth of cancer cells.

In this new study, the researchers have designed a new protein which blocks the hormone receptors and consequently stops prostate cancer cells from growing in the laboratory. The therapy was successful even in circumstances that lead to the failure of conventional treatments.

Dr Charlotte Bevan, senior author of the study, from the Department of Surgery and Cancer at Imperial College London said: "Eleven thousand men die from prostate cancer each year in the UK. Existing treatments are good at first but frequently fail after a couple of years. Once the cancer moves to the more aggressive stage, there are few therapies available.

"Our team is seeking to design a new therapy that will help patients once the other ones have failed. There is a lot of research supporting the idea that the androgen receptor continues to drive prostate cancer growth, so we have been investigating novel methods to block this pathway."

The team is designing a novel therapy by combining two separate proteins to create a hybrid. One half binds to the receptor, whilst the other half blocks the receptor's activity. The research demonstrates that both of these factors are important in blocking activity, and consequently the growth of the cancer.

"So far, the research has only been carried out in prostate cancer cells in the laboratory. These proof of principle experiments are really promising, but more work is needed before these therapies are ready for clinical trials" said Dr Greg Brooke, first author of the study, now at the School of Biological Sciences, University of Essex. "The next step is to continue research in cell models to refine the therapy into something that is specific, potent and easy to deliver.

"It's exciting to think that this research could offer new hope for men with advanced prostate cancer."


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More Than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Study Finds Brain Chemicals that Keep Wakefulness in Check
Researchers to develop new drugs that promote better sleep, or control hyperactivity in people with mania.
Saturday, August 01, 2015
Fossil Fuel Emissions will Complicate Radiocarbon Dating, Warns Scientist
The paper is published in the journal PNAS.
Tuesday, July 21, 2015
Scientists Find New Variant of Streptococcal Bacteria Causing Severe Infections
Researchers noticed a sharp rise in infections caused by emm89.
Wednesday, July 15, 2015
Gene Therapy for Cystic Fibrosis Shows Encouraging Trial Results
A therapy that replaces the faulty gene responsible for cystic fibrosis in patients' lungs has produced encouraging results in a major UK trial.
Friday, July 03, 2015
New Genetic Form of Obesity and Diabetes Discovered
Scientists have discovered a new inherited form of obesity and type 2 diabetes in humans.
Tuesday, June 30, 2015
New Genetic Form of Obesity and Diabetes Discovered
Scientists have discovered a new inherited form of obesity and type 2 diabetes in humans.
Tuesday, June 30, 2015
Researchers Develop New Breath Test to Diagnose Oesophageal and Gastric Cancer
Test will now be tested in a larger trial involving three hospitals in London.
Tuesday, June 23, 2015
'Crumpled' Filter to Slash Energy Consumption
Scientists have developed an ultra-thin, super-strong membrane to filter liquids and gases, with the potential to cut energy consumption in industry.
Friday, June 19, 2015
Imperial Researchers Win Health Foundation Grant for Cancer Innovation Study
Each project will receive over £450,000 of funding to support the research.
Tuesday, May 26, 2015
Engineering Bacteria for Vaccine Delivery
An eight million Euro project has been launched with the aim of engineering bacteria to deliver vaccines against antibiotic-resistant infections.
Monday, May 18, 2015
Diet Swap has Dramatic Effects on Colon Cancer Risk for Americans and Africans
New study confirms that a high fibre diet can substantially reduce risk.
Saturday, May 02, 2015
Alcoholic Hepatitis Treatments Fail to Keep Patients Alive
The study is published in the New England Journal of Medicine.
Friday, May 01, 2015
Urine Profiles Provide Clues To How Obesity Causes Disease
Scientists have identified chemical markers in urine associated with body mass, providing insights into how obesity causes disease.
Thursday, April 30, 2015
Protein That Boosts Immunity to Viruses and Cancer Discovered
Researchers now developing a gene therapy designed to boost the infection-fighting cells.
Saturday, April 18, 2015
Protein That Boosts Immunity To Viruses And Cancer Discovered
Scientists have discovered a protein that plays a central role in promoting immunity to viruses and cancer, opening the door to new therapies.
Friday, April 17, 2015
Scientific News
Study Finds Brain Chemicals that Keep Wakefulness in Check
Researchers to develop new drugs that promote better sleep, or control hyperactivity in people with mania.
Sorting Through Cellular Statistics
Aaron Dinner, professor in chemistry, and his graduate student Herman Gudjonson are trying to read the manual of life, DNA, as part of the Dinner group’s research into bioinformatics—the application of statistics to biological research.
Playing 'Tag' with Pollution lets Scientists See Who's It
Using a climate model that can tag sources of soot from different global regions and can track where it lands on the Tibetan Plateau, researchers have determined which areas around the plateau contribute the most soot — and where.
Women’s Immune System Genes Operate Differently from Men’s
A new technology reveals that immune system genes switch on and off differently in women and men, and the source of that variation is not primarily in the DNA.
Long Telomeres Associated with Increased Lung Cancer Risk
Genetic predisposition for long telomeres predicts increased lung adenocarcinoma risk.
First Artificial Ribosome Designed
Researchers at the University of Illinois at Chicago and Northwestern University have engineered a tethered ribosome that works nearly as well as the authentic cellular component, or organelle, that produces all the proteins and enzymes within the cell.
High-Resolution 3D Images Reveal the Muscle Mitochondrial Power Grid
NIH mouse study overturns scientific ideas on energy distribution in muscle.
Expanding the Brain
A team of researchers has identified more than 40 new “imprinted” genes, in which either the maternal or paternal copy of a gene is expressed while the other is silenced.
Identifying a Key Growth Factor in Cell Proliferation
Researchers discover that aspartate is a limiter of cell proliferation.
Study Uncovers Target for Preventing Huntington’s Disease
Scientists from Cardiff University believe that a treatment to prevent or delay the symptoms of Huntington’s disease could now be much closer, following a major breakthrough.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!