Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

OriGene Awarded NCI Contract

Published: Monday, February 03, 2014
Last Updated: Monday, February 03, 2014
Bookmark and Share
The contract will see OriGene to develop high affinity anti-peptide antibodies for SISCAPA assays.

Stable Isotope Standards and Capture by Anti-Peptide Antibodies (SISCAPA) , an approach developed by Dr. Leigh Anderson , is a novel technology that  can achieve high sensitivity quantitation of proteins in clinical samples using  affinity - capture  SRM Mass spectrometry. One of the most desirable aspects of SISCAPA technology is that it h as the potential for simultaneous quantification of multiple  proteins from a given sample making it is highly desirable in  many applications to minimize sample requirements, handling, and assay costs per analyte . However, the capabilities of the SISCAPA technique are currently limited due to the scarcity of high  affinity antibodies to the specific peptides that are generated by the fragmentation  of the target  protein before analysis.  

Producing high quality antibodies for SISCAPA assays fits well with OriGene's long term goal  of developing perfect assays for every human protein. The development of these  antibodies is being performed  in  partnership with the Institute for Systems Biology (ISB) and in  coordination with NCI's Clinical Proteomic Technologies for Cancer (CPTC) group. OriGene has previously collaborated with Dr. Robert Moritz , Director of Proteomics Research at ISB , for the generation  of mass spec peptide profiles from over 5000  full length  human proteins for inclusion in the complete human SRMAtlas . For the generation of high - affinity SISCAPA antibodies under this contract, OriGene will utilize a novel immunization  strategy to develop high antibody titers in rabbits and will utilize the  proteomics capabilities of the Moritz lab to identify , isolate and characterize the highest affinity antibodies suitable for SISCAP A approaches . 

Dr. James Lazar, Vice President of Assay Development said, “OriGene is pleased to have been selected by NCI to receive this contract and to work with Dr. Moritz , a leader in this field. We believe that OriGene’s unique expertise in antibody development  will enable the true potential of SISCAP A technology and contribute to the development of important clinical assays”. 

Dr. Moritz commented : “ This is a fantastic opportunity  where we continue our collaboration  with OriGene  and combin e our collective knowledge and expertise in antibody generation and  protein chemistry to provide  ‘digitized ’ antibodies for the NCI CPTC program at the NIH and  support the effort of shared resources .”  


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More Than 4,600+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

OriGene Awarded Contract to Develop Monoclonal Antibodies for SISCAPA
OriGene Technologies have announced that they have been awarded a Phase II SBIR contract from the National Cancer Institute (NCI) to develop high-affinity, anti-peptide antibodies for mass-spectrometry-based serum biomarker detection/ quantification assays.
Monday, January 11, 2016
OriGene Technologies Announces the Acquisition of ZsBio
Acquisition establishes OriGene's leading position in the Chinese pathology testing market.
Tuesday, March 13, 2012
OriGene Releases 1500 TrueMAB™ Monoclonal Antibodies
Extensively validated monoclonal antibodies made against native protein antigens for superior IHC, IF, ELISA and flow applications.
Monday, January 24, 2011
OriGene Technologies Acquires Blue Heron Biotechnology
OriGene’s collection of human cDNA clones together with Blue Heron’s gene synthesis capacity provides a whole product solution for the life sciences community.
Tuesday, August 17, 2010
Scientific News
Platelets are the Pathfinders for Leukocyte Extravasation During Inflammation
Findings from the study could help in the prevention and treatment of inflammatory pathologies.
ASMS 2016: Targeting Mass Spectrometry Tools for the Masses
The expanding application range of MS in life sciences, food, energy, and health sciences research was highlighted at this year's ASMS meeting in San Antonio, Texas.
Benchtop Automation Trends
Gain a better understanding of current interest in and future deployment of benchtop automated systems.
Manufactured Stem Cells to Advance Clinical Research
Clinical-grade cell line will enable development of new therapies and accelerate early-stage clinical research.
Dengue Virus Exposure May Amplify Zika Infection
Researchers at Imperial College London have found that the previous exposure to the dengue virus may increase the potency of Zika infection.
Gender Determination in Forensic Investigations
This study investigated the effectiveness of lip print analysis as a tool in gender determination.
Identifying Novel Types of Forensic Markers in Degraded DNA
Scientists have tried to verify the nucleosome protection hypothesis by discovering STRs within nucleosome core regions, using whole genome sequencing.
Proteins in Blood of Heart Disease Patients May Predict Adverse Events
Nine-protein test shown superior to conventional assessments of risk.
Higher Frequency of Huntington's Disease Mutations Discovered
University of Aberdeen study shows that the gene change that causes Huntington's disease is much more common than previously thought.
Starving Stem Cells May Enable Scientists To Build Better Blood Vessels
Researchers from the University of Illinois at Chicago College of Medicine have uncovered how changes in metabolism of human embryonic stem cells help coax them to mature into specific cell types — and may improve their function in engineered organs or tissues.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,600+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!