Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Genomics England's Plans for 100,000 Genomes Mature

Published: Friday, February 07, 2014
Last Updated: Friday, February 07, 2014
Bookmark and Share
Genomics England has been reporting on progress and plans for implementation of the 100,000 Genomes Project over the coming year.

A pilot study sequencing 2,000 whole genomes from patients with suspected, undiagnosed rare diseases (in collaboration with the University of Cambridge) is already underway, with another to sequence 3,000 patient and patient tumour genomes from cancer patients (in collaboration with Cancer Research UK) is due to begin soon.

Genomics England (GeL) is currently analysing the results from fifteen trial genome sequences from cancer patients produced using different sequencing technologies by the Royal Marsden Hospital, in order to compare their performance. The main part of the programme is due to begin at the start of 2015, sequencing 30,000 whole genomes per year for three years to achieve the planned total of 100,000 by the end of 2017.

GeL has announced the appointment of James Peach as Managing Director for this programme; James is perhaps best known for his role as director for the CRUK Stratified Medicine Programme, and also served on the Department of Health’s Human Genomics Strategy Group (HGSG) along with many well-known figures from the UK genomics community (including PHG Foundation Director Dr Hilary Burton).

Membership of the GeL Board of Directors and four GeL committees (overseeing science, data, communications and engagement and ethics) has also reportedly been confirmed, though only two committee chairs are specified (Vivienne Parry for the communications and engagement group and Professor Mike Parker for the ethics group).

Meanwhile, GeL has also reached an agreement with the Wellcome Trust Sanger Institute to host the online Ethics and Genomics survey they produced and launched in 2012 to inform their own research in the area, so that visitors to the GeL website will be encouraged to participate. This will obviously provide a further boost to numbers of respondents for the survey and visitors are encouraged to participate as they ‘will be exploring the same ethical questions that Michael and his committee are addressing on behalf of Genomics England’, with the intriguing suggestion that ‘Your response to some of the questions may surprise you’.

A blog by GeL’s ethics programme manager Laura Riley sets out many of the ethical questions the ethics advisory committee will be examining, although interestingly the consideration about issues of feedback to patients, incidental findings and so on remains firmly in the context of patients as participants in research rather than receiving an NHS medical service – which latter is of course a different situation, and the one currently giving rise to the greatest concerns about implementation.

One of the questions currently under investigation by the PHG Foundation’s Realising Genomics project is whether the distinction between clinical and research ethics and practice actually make sense in the genomics era. GeL is well placed to learn important lessons about large-scale genomic research, but this will not necessarily address all the issues relevant for the introduction of personalised medicine in the clinic. 


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More Than 4,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Consultation on Cancer Biobanking Standards
The Confederation of Cancer Biobanks (CCB) hosted by the National Cancer Research Institute (NCRI) is holding a consultation on standards.
Monday, August 12, 2013
Developments in Clinical Genome and Exome Sequencing
Increasing numbers of US medical centres are offering clinical exome or whole genome sequencing.
Tuesday, July 30, 2013
Scientific News
Open Source Seed Initiative – A Welcome Boost to Global Crop Breeding
A team of plant breeders, farmers, non-profit agencies, seed advocates, and policymakers have created the Open Source Seed Initiative.
ASMS 2016: Targeting Mass Spectrometry Tools for the Masses
The expanding application range of MS in life sciences, food, energy, and health sciences research was highlighted at this year's ASMS meeting in San Antonio, Texas.
Benchtop Automation Trends
Gain a better understanding of current interest in and future deployment of benchtop automated systems.
Anthrax Proteins Might Help Treat Cancerous Tumors
Studies in mice reveal novel treatment regimen.
New Cancer Drug Target Found in Dual-Function Protein
Findings from a study from TSRI have shown that targeting a protein called GlyRS might help to halt cancer growth.
Key to Chronic Fatigue Syndrome is in Your Gut, Not Head
Researchers report they have identified biological markers of the disease in gut bacteria and inflammatory microbial agents in the blood.
HIV Structure Stabilized
Findings represent ‘big accomplishment’ in biomedical engineering and design.
Four Newly-Identified Genes Could Improve Rice
A Japanese research team have applied a method used in human genetic analysis to rice and rapidly discovered four new genes that are potentially significant for agriculture. These findings could influence crop breeding and help combat food shortages caused by a growing population.
New Cancer Drug Target in Dual-Function Protein
Scientists at The Scripps Research Institute (TSRI) have identified a protein that launches cancer growth and appears to contribute to higher mortality in breast cancer patients.
Antibodies To Dengue May Alter Course Of Zika Virus Infection
Scientists at Emory Vaccine Center, in collaboration with investigators from Thailand, have found that people infected with dengue virus develop antibodies that cross-react with Zika virus.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!