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First SYGNIS QualiPhi®-based Products Launched by QIAGEN

Published: Thursday, February 13, 2014
Last Updated: Thursday, February 13, 2014
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QualiPhi®, now renamed SensiPhi®, targets sophisticated applications for DNA amplification.

SYGNIS AG has announced that its partner QIAGEN has launched the first two products of a series of kits based on SYGNIS’ proprietary amplification technology QualiPhi® now renamed SensiPhi®.

The two kits, REPLI-g WTA Single Cell Kit and REPLI-g Cell WGA & WTA Kit, are available now and will be commercialized globally through QIAGEN’s established distribution channels. The product launches result from a global exclusive license agreement with QIAGEN signed in 2012.

“We are at the beginning of a series of product launches that we believe will establish our polymerase as the potential future gold standard for isothermal amplification of DNA”, Pilar de la Huerta, CEO of SYGNIS stated.

Huerta continued, “With the launch of the first products based on our proprietary technology, SYGNIS continues to deliver on its objectives. It is a mark of our success as a company to have our product commercialized by the world leader QIAGEN.”

“We are very pleased with the launch of our new kits based on the polymerase provided by SYGNIS”, commented Achim Ribbe, Vice President Corporate Business Development Licensing at QIAGEN. “The REPLI-g WTA Single Cell and REPLI-g Cell WGA & WTA address key user challenges in NGS and other downstream applications, where DNA sequence analysis is limited by small amounts down to single cells of available sample material. To drive adoption of NGS in the clinical space, QIAGEN is building a broad portfolio of universal products including the REPLI-g Single Cell Kits which are compatible with any major NGS platform and which also support our own integrated sample-to-insight GeneReader workflow currently in development.”

SensiPhi® is the second generation of a DNA polymerase that was licensed from the Spanish National Research Council (CSIC) in 2010. Due to its unique properties, first studies suggest that it has the potential to improve the amplifications of whole genomes and large stretches of DNA.

SYGNIS’ SensiPhi® is a high efficiency, high fidelity polymerase for DNA amplification which conveys the outstanding properties in terms of speed, accuracy and length of DNA fragments to be amplified.

It differs from PCR since it provides generic amplification of the complete genome, whereas PCR is designed to detect predefined target sequences, and therefore only amplifies specific, mostly very short fragments of the DNA.


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