Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

BioDiscovery Releases Nexus Copy Number Version 7.5

Published: Friday, February 14, 2014
Last Updated: Friday, February 14, 2014
Bookmark and Share
New NGS module for DNA copy number and sequence variation analysis and visualization.

BioDiscovery, Inc. has announced the release of version 7.5 of Nexus Copy Number software, the leading platform for analysis of sequence and structural variation from microarray and NGS platforms.

Version 7.5 introduces a new NGS module for analysis of sequence variants from array or NGS platforms, and detection of copy number from sequencing data. The software expands support for the Affymetrix platform with support for the OncoScan™ FFPE Assay Kit and Affymetrix Axiom® Human Genotyping array.

Notable features for the case review workflow include new filters that quickly cut variations down to potential pathogenic ones, including a trio analysis filter to removes parental calls from the proband, and the ability to display previous samples containing a variant under review.

For cancer applications, improvements include ASCAT 2.1, which does not require a matched normal, and the ability to detect CNVs from whole-genome and whole-exome sequencing.

“We have seen a significant increase in interest in obtaining copy number from sequencing data and we have introduced some methods for this in Nexus Copy Number 7.5,” said Dr. Soheil Shams, CEO, BioDiscovery, Inc. “We have also implemented a version of ASCAT 2.1 for complex tumor samples without paired normal, added many features for cytogenetics users to speed case review, introduced features for trio analysis, and have added a host of small usability enhancements throughout. BioDiscovery is committed to making data analysis easier for the end-user and will continue to expand the product with solutions that grow with changing technology.”

Nexus Copy Number’s unique feature of integrated analysis allows identification of sequence variants overlapping copy number aberrations or homozygous regions and with version 7.5 this integration is taken a step further with the ability to store and query sequence variants in the Nexus DB genomic data repository.

Users can search the extensive Nexus DB library (containing data from sources such as TCGA, GEO, AGRE, and ISCA) for sequence variants, loss of heterozygosity , and copy number changes to find previous reported cases or similar aberration profiles among other diseases.

BioDiscovery Nexus Copy Number can integrate and process together, in a single project, data from commercial array platforms such as Agilent, Affymetrix, Illumina, Roche NimbleGen, custom arrays and data from Next-Gen platforms such as Ion Torrent, Illumina MiSeq, HiSeq, Complete Genomics, and others.

The software is applicable to many types of studies from focused projects of a cytogeneticist to large scale cancer or GWAS studies. BioDiscovery is attuned to such different needs and offers the product in a flexible and modular system allowing users to create configurations that are suited to their needs.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More Than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

BioDiscovery Awarded National Institutes of Health SBIR Grant
SBIR Phase I grant to improve the copy number variation data from TCGA.
Thursday, July 10, 2014
N-of-One and BioDiscovery Partner
Partnership equips laboratories and oncologists with a foundation for genomic data analysis through to therapeutic options.
Tuesday, March 25, 2014
BioDiscovery Initiates Software Donation Program to Benefit Pediatric Research
Company to donate up to $100,000 worth of software licenses per year to eligible scientists working in pediatric research.
Monday, January 07, 2013
BioDiscovery and AGRE Enter into a Co-Promotion Agreement
Agreement allows AGRE to provide copy number and allelic event data to its research users.
Wednesday, September 19, 2012
Cancer Centers Renew and Expand BioDiscovery’s Nexus Copy Number Software Licenses
BioDiscovery announces a number of license renewals and expansions of its Nexus Copy Number product at leading cancer research centers.
Wednesday, December 16, 2009
Fox Chase Cancer Center Adopts Nexus Copy Number and Nexus Expression
The center's Keystone Program in Blood Cell Development and Cancer gains a site license for two bioinformatics software programs from BioDiscovery.
Wednesday, February 11, 2009
BioDiscovery Granted its 7th U.S. Patent for Microarray Image Analysis
The patent covers the fundamental step of quantifying spots in microarray images.
Friday, January 27, 2006
United Bioinformatica Inc. to distribute BioDiscovery products to Canadian market

Thursday, April 17, 2003
BioDiscovery Inc. and Genops Bioinformatics Inc. Collaboration

Thursday, February 27, 2003
BioDiscovery and Azign Bioscience in silico Collaboration

Tuesday, October 29, 2002
BioDiscovery Distribution Agreement With Sigma-Genosys

Wednesday, July 24, 2002
BioDiscovery Inc. and Genops Bioinformatics Inc. Collaboration

Wednesday, February 27, 2002
Scientific News
Lung Repair and Regeneration Gene Discovered
New role for hedgehog gene offers better understanding of lung disease.
How Cell Growth Triggers Cell Division
Researchers in Jan Skotheim's lab have discovered a previously unknown mechanism that controls how large cells grow, an insight that could one day provide insight into attacking diseases such as cancer.
Microbe Sleuth
Tanja Bosak examines how life and the Earth evolved in tandem during their early history together.
3 Ways Viruses Have Changed Science for the Better
Viruses are really good at what they do, and we’ve been able to harness their skills to learn about – and potentially improve – human health in several ways.
Restoring Vision with Stem Cells
Age-related macular degeneration (AMRD) could be treated by transplanting photoreceptors produced by the directed differentiation of stem cells, thanks to findings published today by Professor Gilbert Bernier of the University of Montreal and its affiliated Maisonneuve-Rosemont Hospital.
The Age of Humans Controlling Microbes
Engineered bacteria could soon be used to detect environmental toxins, treat diseases, and sustainably produce chemicals and fuels.
Mixed Up Cell Transportation Key Piece of ALS and Dementia Puzzle
Researchers from the University of Toronto are one step closer to solving this incredibly complex puzzle, offering hope for treatment.
Metabolomic Platform Reveals Fundamental Flaw in Common Lab Technology
A new study led by scientists at The Scripps Research Institute (TSRI) shows that a technology used in thousands of laboratories, called gas chromatography mass spectrometry (GC-MS), fundamentally alters the samples it analyzes.
Atriva Therapeutics GmbH Develops Innovative Flu Drug
Highly effective against seasonal and pandemic influenza.
New Gene Therapy for Vision Loss From a Mitochondrial Disease
NIH-funded study shows success in targeting mitochondrial DNA in mice.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos