Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

BioDiscovery Releases Nexus Copy Number Version 7.5

Published: Friday, February 14, 2014
Last Updated: Friday, February 14, 2014
Bookmark and Share
New NGS module for DNA copy number and sequence variation analysis and visualization.

BioDiscovery, Inc. has announced the release of version 7.5 of Nexus Copy Number software, the leading platform for analysis of sequence and structural variation from microarray and NGS platforms.

Version 7.5 introduces a new NGS module for analysis of sequence variants from array or NGS platforms, and detection of copy number from sequencing data. The software expands support for the Affymetrix platform with support for the OncoScan™ FFPE Assay Kit and Affymetrix Axiom® Human Genotyping array.

Notable features for the case review workflow include new filters that quickly cut variations down to potential pathogenic ones, including a trio analysis filter to removes parental calls from the proband, and the ability to display previous samples containing a variant under review.

For cancer applications, improvements include ASCAT 2.1, which does not require a matched normal, and the ability to detect CNVs from whole-genome and whole-exome sequencing.

“We have seen a significant increase in interest in obtaining copy number from sequencing data and we have introduced some methods for this in Nexus Copy Number 7.5,” said Dr. Soheil Shams, CEO, BioDiscovery, Inc. “We have also implemented a version of ASCAT 2.1 for complex tumor samples without paired normal, added many features for cytogenetics users to speed case review, introduced features for trio analysis, and have added a host of small usability enhancements throughout. BioDiscovery is committed to making data analysis easier for the end-user and will continue to expand the product with solutions that grow with changing technology.”

Nexus Copy Number’s unique feature of integrated analysis allows identification of sequence variants overlapping copy number aberrations or homozygous regions and with version 7.5 this integration is taken a step further with the ability to store and query sequence variants in the Nexus DB genomic data repository.

Users can search the extensive Nexus DB library (containing data from sources such as TCGA, GEO, AGRE, and ISCA) for sequence variants, loss of heterozygosity , and copy number changes to find previous reported cases or similar aberration profiles among other diseases.

BioDiscovery Nexus Copy Number can integrate and process together, in a single project, data from commercial array platforms such as Agilent, Affymetrix, Illumina, Roche NimbleGen, custom arrays and data from Next-Gen platforms such as Ion Torrent, Illumina MiSeq, HiSeq, Complete Genomics, and others.

The software is applicable to many types of studies from focused projects of a cytogeneticist to large scale cancer or GWAS studies. BioDiscovery is attuned to such different needs and offers the product in a flexible and modular system allowing users to create configurations that are suited to their needs.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More Than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

BioDiscovery Awarded National Institutes of Health SBIR Grant
SBIR Phase I grant to improve the copy number variation data from TCGA.
Thursday, July 10, 2014
N-of-One and BioDiscovery Partner
Partnership equips laboratories and oncologists with a foundation for genomic data analysis through to therapeutic options.
Tuesday, March 25, 2014
BioDiscovery Initiates Software Donation Program to Benefit Pediatric Research
Company to donate up to $100,000 worth of software licenses per year to eligible scientists working in pediatric research.
Monday, January 07, 2013
BioDiscovery and AGRE Enter into a Co-Promotion Agreement
Agreement allows AGRE to provide copy number and allelic event data to its research users.
Wednesday, September 19, 2012
Cancer Centers Renew and Expand BioDiscovery’s Nexus Copy Number Software Licenses
BioDiscovery announces a number of license renewals and expansions of its Nexus Copy Number product at leading cancer research centers.
Wednesday, December 16, 2009
Fox Chase Cancer Center Adopts Nexus Copy Number and Nexus Expression
The center's Keystone Program in Blood Cell Development and Cancer gains a site license for two bioinformatics software programs from BioDiscovery.
Wednesday, February 11, 2009
BioDiscovery Granted its 7th U.S. Patent for Microarray Image Analysis
The patent covers the fundamental step of quantifying spots in microarray images.
Friday, January 27, 2006
United Bioinformatica Inc. to distribute BioDiscovery products to Canadian market

Thursday, April 17, 2003
BioDiscovery Inc. and Genops Bioinformatics Inc. Collaboration

Thursday, February 27, 2003
BioDiscovery and Azign Bioscience in silico Collaboration

Tuesday, October 29, 2002
BioDiscovery Distribution Agreement With Sigma-Genosys

Wednesday, July 24, 2002
BioDiscovery Inc. and Genops Bioinformatics Inc. Collaboration

Wednesday, February 27, 2002
Scientific News
Health Risks of Saturated Fats Aggravated by Immune Response
Research shows that the presence of saturated fats resulted in monocytes migrating into the tissues of vital organs.
Changing the Biological Data Visualisation World
Scientists at TGAC, alongside European partners, have created a cutting-edge, open source community for the life sciences.
NIH Study Finds Calorie Restriction Lowers Some Risk Factors for Age-Related Diseases
Two-year trial did not produce expected metabolic changes, but influenced other life span markers.
Immunotherapy Agent Benefits Patients with Drug-Resistant Multiple Myeloma in First Human Trial
Daratumumab proved generally safe in patients, even at the highest doses.
Low-level Arsenic Exposure Before Birth Associated with Early Puberty in Female Mice
Study examine whether low-dose arsenic exposure could have similar health outcomes in humans.
Inciting an Immune Attack On Cancer Cells
A new minimally invasive vaccine that combines cancer cells and immune-enhancing factors could be used clinically to launch a destructive attack on tumors.
‘Mutation-Tracking’ Blood Test for Breast Cancer
Scientists have developed a blood test for breast cancer able to identify which patients will suffer a relapse after treatment, months before tumours are visible on hospital scans.
Cellular Contamination Pathway for Heavy Elements Identified
Berkeley Lab scientists find that an iron-binding protein can transport actinides into cells.
Intensity of Desert Storms May Affect Ocean Phytoplankton
MIT study finds phytoplankton are extremely sensitive to changing levels of desert dust.
Common ‘Heart Attack’ Blood Test May Predict Future Hypertension
Small rises in troponin levels may have value as markers for subclinical heart damage and high blood pressure.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!