Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

$3M NIH Grant Enables Baylor International HIV/AIDS Program

Published: Wednesday, February 19, 2014
Last Updated: Wednesday, February 19, 2014
Bookmark and Share
Researchers to study genetic differences of disease in sub-Saharan African children.

A $3 million, three-year grant from the National Institutes of Health will enable researchers from the Baylor International Pediatric AIDS Initiative at Texas Children’s Hospital to study the genetic factors that affect the progression of tuberculosis and HIV in one of the largest populations infected with the diseases yet to be studied– children in sub-Saharan Africa.

The grant will establish The Collaborative African Genomics Network (CAfGEN) and include collaborators from two BIPAI sites - the Botswana-Baylor Children’s Centre of Excellence and the Baylor-Uganda Children’s Clinical Center of Excellence, along with Makerere University in Uganda, the University of Botswana, and Baylor College of Medicine.  

Working to improve treatments
“Advanced genetic and genomic technologies have the promise to transform our understanding and approach to health and human diseases,” said Dr. Graeme Mardon, professor of molecular and human genetics and pathology & immunology at Baylor and principal investigator of the Baylor portion of the grant.

The team will use state-of-the-art genomic technologies to study a rare group of HIV-infected children who can control the infection for years without needing anti-retroviral therapy to prevent AIDS. They will also be following a group of HIV positive children infected with tuberculosis to identify new genes associated with disease progression.

Their ultimate goal is to offer improved diagnostics and new therapeutic avenues in tuberculosis and HIV/AIDS.

“Most of the previous genetic studies in HIV were undertaken in non-African, adult populations,” said Dr. Gabriel Anabwani, executive director of the Botswana-Baylor Children’s Center of Excellence and the lead principal investigator of the grant. “There is a great need to study the genetic factors of progression in children; their disease differs considerably from their adult counterparts and they potentially have more to gain from therapeutic advances.”

Genomic expertise
The clinical centers will provide expertise for patient recruitment while the universities will provide local molecular genetic resources. Baylor, home to one of the top-rated genetics programs in the United States, will bring to the partnership access to genomics expertise and resources that will ultimately be transitioned to African researchers and institutions through an extensive training program designed to develop highly-knowledgeable geneticists in African nations.

Other principal investigators include Drs. Oathokwa Nkomazana and Sununguko Mpoloka from the University of Botswana; Dr. Moses Joloba from Makerere University; and Dr. Adeodata Kekitiinwa from the Baylor-Uganda Children’s Clinical Center of Excellence. Other key Baylor investigators include Dr. Neil Hanchard, assistant professor of molecular and human genetics, and Dr. Chester Brown, associate professor of molecular and human genetics and of pediatrics.

The grant will also help establish core genomics facilities in Botswana and Uganda, with trainees from those institutions having the chance to work in several highly-regarded core laboratories at BCM including the Human Genome Sequencing Center, the Laboratory for Translational Genomics in the Children’s Nutrition Research Center, and the Center for Statistical Genetics.

“The excitement of this grant is not only the potential for improved care in childhood HIV, but the improvements in knowledge and infrastructure that will serve the people of Africa for many years to come,” said Kekitiinwa. 


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More Than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Myeloid-Derived Suppressor Cells Play Role in Tumor Growth
Researchers at Baylor College of Medicine have reported a new mechanism that helps cancer cells engage myeloid-derived suppressor cells.
Friday, May 20, 2016
Largest Genomic Study on Kidney Cancer
Understanding the complexity of cancer is a major goal of the scientific community, and for kidney cancer researchers this goal just got closer.
Wednesday, March 16, 2016
Largest Genomic Study on Kidney Cancer Brings Hope for More Effective Treatments
Researchers at Baylor College of Medicine have found that a pathway called immune checkpoint was most active in a subtype of clear cell kidney cancer that is typically very aggressive.
Tuesday, March 08, 2016
Baylor, DNAnexus Collaborate
Partnership sets out to develop HgV, a new iteration of HGSC's Mercury, a BCM-developed data processing and variant calling pipeline for analyzing and annotating next-generation sequencing data in research and clinical contexts.
Tuesday, June 23, 2015
Baylor, TGen Collaborate on Personalized Cancer Treatment Options
The companies will collaborate on precision medicine for cancer patients by offering liquid biopsies, performing gene sequencing, conducting clinical trials, and creating personalized vaccines.
Tuesday, May 26, 2015
Role of Cancer Stem Cells in Chemo-Resistance
'Wound response' of cancer stem cells may explain chemo-resistance in bladder cancer.
Friday, December 05, 2014
Massimo Pietropaolo Named McNair Scholar at Baylor
World renowned physician-scientist in type 1 diabetes research, Dr. Massimo Pietropaolo, has been named McNair Scholar at Baylor College of Medicine.
Wednesday, October 29, 2014
Clinical Integration of NGS
Experts provide much-needed policy analysis for clinical integration of next generation sequencing.
Tuesday, September 23, 2014
Collaboration Unravels Novel Mechanism for Neurological Disorder
The novel gene (CLP1) associated with a neurological disorder affecting both the peripheral and central nervous systems.
Saturday, April 26, 2014
Baylor College of Medicine, Berry Genomics Co. Seek to Improve on Prenatal Genetic Tests
Teams aim to improve prenatal genetic testing by combining BCM’s expertise in using microarrays for DNA analysis and Berry’s non-invasive technology evaluating fetal DNA in maternal plasma.
Monday, January 07, 2013
Microarray Analysis Improves Prenatal Diagnosis
A "chip" or array that can quickly detect disorders such as Down syndrome, or other diseases associated with chromosomal abnormalities, has proved an effective tool in prenatal diagnosis in 300 cases, as reported by Baylor College of Medicine.
Tuesday, November 29, 2011
Experimental Drug Targets Chemo-Resistant Breast Cancer Stem Cells
The cells that remain after treatment that could potentially refuel tumor growth, researchers say.
Monday, December 14, 2009
Protein 'Tubules' Free Avian Flu Virus from Immune Recognition
Two domains or portions of the protein NS1 combine to form tiny tubules where double-stranded RNA is hidden from the immune system, researchers say.
Friday, November 07, 2008
High Throughput Imaging Speeds Analysis of Hormone Receptors
A new high throughput microscopy technique enabled researchers at Baylor College of Medicine to analyze thousands of individual cells expressing androgen receptor.
Monday, November 03, 2008
Lack of Fragile X, Related Gene Disrupts Sleep
Deficiency of the FMR1 gene and a similar gene called FXR2 could account for sleep problems associated with inherited mental impairment.
Friday, June 27, 2008
Scientific News
The Rise of 3D Cell Culture and in vitro Model Systems for Drug Discovery and Toxicology
An overview of the current technology and the challenges and benefits over 2D cell culture models plus some of the latest advances relating to human health research.
Scientists Find Evidence That Cancer Can Arise Changes
Researchers at Rockefeller University have found a mutation that affects the proteins that package DNA without changing the DNA itself can cause a rare form of cancer.
Developing a More Precise Seasonal Flu Vaccine
During the 2014-15 flu season, the poor match between the virus used to make the world’s vaccine stocks and the circulating seasonal virus yielded a vaccine that was less than 20 percent effective.
A Peachy Defense System for Seeds
ETH chemists are developing a new coating method to protect seeds from being eaten by insects. In doing so, they have drawn inspiration from the humble peach and a few of its peers.
Fighting Cancer with Borrowed Immunity
A new step in cancer immunotherapy: researchers from the Netherlands Cancer Institute and University of Oslo/Oslo University Hospital show that even if one's own immune cells cannot recognize and fight their tumors, someone else's immune cells might.
Modified Microalgae Converts Sunlight into Valuable Medicine
A special type of microalgae can soon produce valuable chemicals such as cancer treatment drugs and much more just by harnessing energy from the sun.
Breakthrough Approach to Breast Cancer Treatment
Scripps scientists have designed a drug candidate that decreases growth of breast cancer cells.
Loss Of Y Chromosome Increases Risk Of Alzheimer’s
Men with blood cells that do not carry the Y chromosome are at greater risk of being diagnosed with Alzheimer’s disease. This is in addition to an increased risk of death from other causes, including many cancers. These new findings by researchers at Uppsala University could lead to a simple test to identify those at risk of developing Alzheimer’s disease.
Making Virus Sensors Cheap and Simple
Researchers at The University of Texas at Austin demonstrated the ability to detect single viruses in a solution containing murine cytomegalovirus (MCMV).
A Guide to CRISPR Gene Activation
A comparison of synthetic gene-activating Cas9 proteins can help guide research and development of therapeutic approaches.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!