Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

Princeton Instruments Camera Used to Measure 2D SFG Spectrum of a Peptide

Published: Friday, March 14, 2014
Last Updated: Friday, March 14, 2014
Bookmark and Share
Researchers at UW-Madison measure two-dimensional sum frequency generation spectrum using PIXIS:400B CCD camera.

Princeton Instruments hails the landmark 2D SFG measurements performed on an interface-bound peptide by the Zanni group at the University of Wisconsin-Madison.

Details of this work can be found in the recently published article, “Two-Dimensional Sum-Frequency Generation Reveals Structure and Dynamics of a Surface-Bound Peptide” [J. Am. Chem. Soc., 2014, 136 (3), pp 956–962; DOI: 10.1021/ja408682s].

Led by professor of chemistry Martin Zanni, the UW-Madison research group measured the two-dimensional sum frequency generation (SFG) spectrum of a peptide bound to a gold surface using a Princeton Instruments PIXIS:400B CCD camera.

Determination of the secondary structure of interface-bound peptides is a powerful tool in the investigation of such protein-misfolding disorders as Alzheimer’s disease and diabetes.

Unlike conventional linear spectroscopic methods, 2D IR and 2D SFG provide unambiguous information about the structure and dynamics of target molecules.

Emerging nonlinear spectroscopic methods like 2D IR require highly sensitive photodetectors. Commercialized by companies such as PhaseTech Spectroscopy (Madison, WI), these increasingly popular techniques offer an exciting new approach toward resolving the challenging medical problems posed by protein-misfolding diseases.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More Than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

IsoPlane Spectrograph Used in Raman Research
Award-winning IsoPlane spectrograph recently used in SMTERS research by Van Duyne group.
Tuesday, November 05, 2013
New President Appointed at Princeton Instruments
Promotion of William Asher to President of Princeton Instruments.
Friday, July 19, 2013
Princeton Instruments’ IsoPlane Spectrograph Wins R&D 100 Award
R&D 100 Awards will be presented at a ceremony in Orlando, Florida on November 7th, 2013.
Thursday, July 11, 2013
Princeton Instruments Announces Appointments to Sales & Marketing Team
Appointment of Mr. Ravi Guntupalli to the position of Vice President of Sales & Marketing.
Monday, July 02, 2012
Scientific News
Lung Repair and Regeneration Gene Discovered
New role for hedgehog gene offers better understanding of lung disease.
How Cell Growth Triggers Cell Division
Researchers in Jan Skotheim's lab have discovered a previously unknown mechanism that controls how large cells grow, an insight that could one day provide insight into attacking diseases such as cancer.
Microbe Sleuth
Tanja Bosak examines how life and the Earth evolved in tandem during their early history together.
3 Ways Viruses Have Changed Science for the Better
Viruses are really good at what they do, and we’ve been able to harness their skills to learn about – and potentially improve – human health in several ways.
Restoring Vision with Stem Cells
Age-related macular degeneration (AMRD) could be treated by transplanting photoreceptors produced by the directed differentiation of stem cells, thanks to findings published today by Professor Gilbert Bernier of the University of Montreal and its affiliated Maisonneuve-Rosemont Hospital.
The Age of Humans Controlling Microbes
Engineered bacteria could soon be used to detect environmental toxins, treat diseases, and sustainably produce chemicals and fuels.
Mixed Up Cell Transportation Key Piece of ALS and Dementia Puzzle
Researchers from the University of Toronto are one step closer to solving this incredibly complex puzzle, offering hope for treatment.
Metabolomic Platform Reveals Fundamental Flaw in Common Lab Technology
A new study led by scientists at The Scripps Research Institute (TSRI) shows that a technology used in thousands of laboratories, called gas chromatography mass spectrometry (GC-MS), fundamentally alters the samples it analyzes.
Atriva Therapeutics GmbH Develops Innovative Flu Drug
Highly effective against seasonal and pandemic influenza.
New Gene Therapy for Vision Loss From a Mitochondrial Disease
NIH-funded study shows success in targeting mitochondrial DNA in mice.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos