Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

European Research Project Aims at Early Diagnosis of Memory Disorders

Published: Thursday, March 20, 2014
Last Updated: Thursday, March 20, 2014
Bookmark and Share
800 patients to participate in testing new diagnostic procedures.

The PredictND project, started by European research organizations, aims at developing and validating new procedures for the earlier diagnosis of memory disorders and for detecting individuals at high risk of developing memory disorders.

Millions of Europeans who are at risk for experiencing any kind of memory loss would benefit from such a solution. The novel approach will be tested on 800 patients in four hospitals in Finland, Denmark, the Netherlands and Italy. The PredictND project is coordinated by VTT Technical Research Centre of Finland and funded by the EU.

Diagnostics of memory disorders is complicated, as multiple reasons can explain the degeneration of cognitive capacity. Alzheimer’s disease is the most common reason explaining 60-70% of cases. Today no single test or biomarker can predict whether a particular person will develop Alzheimer´s disease.

On top of that, clinicians experience an overload of information: they need to combine information from multiple tests and biomarkers in order to find the correct reason and name for the disease.

The PredictND research project, co-funded under the European 7thFramework Programme, will not only develop new, cost-efficient methods for enabling earlier and more reliable diagnostics of different memory disorders in clinical practice; PredictND will also provide computer-based tools that help clinicians form a holistic view of the patient by combining information from several sources, such as clinical tests, imaging and blood samples, and by comparing these measurements to previously diagnosed cases available in hospital databases.

"Alongside the better prediction of memory disorders, PredictND wants to provide a completely new approach for clinicians to systematically manage the information load that they are facing in current clinical practice", says Dr Jyrki Lötjönen, Scientific Coordinator of PredictND, VTT. "For that, we intend to transfer state-of-the-art computer-based technologies, for example for image analysis and machine learning, to a modern hospital environment in order to assist clinicians in their daily work. At the earliest, the new diagnostics tool could enter the market in a couple of years.”

The novel approach will be tested on 800 patients in four top hospitals in Europe: Kuopio (Finland), Copenhagen (Denmark), Amsterdam (the Netherlands) and Perugia (Italy), and compared with the existing diagnostic procedures.

Early detection is crucial
"This project has been granted European funding because increasing the quality of life in Europe is high on our agenda, and memory disorders affect this seriously", explains Project Officer Amalia Vlad of the European Commission. "To treat these disorders, early detection and an accurate diagnosis are essential."

It is important to predict memory disorders before the symptoms start, especially in Alzheimer's disease where the pathological process leads to the death of brain cells. New cost-efficient methods are needed for detecting persons at high risk and corroborating this with new ways of intervention. PredictND will develop novel cost-efficient biomarkers for the early detection of persons at high risk.

One of the project partners, GE Healthcare, has already developed a PET amyloid imaging agent, a potentially powerful tool in aiding the diagnosis of Alzheimer's disease. "But results from this tool must be combined with other types of information to fully characterize the patient", says Dr Lennart Thurfjell, Head of Biomarkers and Software, Medical Diagnostics at GE Healthcare.

Big data
The use of modern machine learning techniques and the exploitation of large databases, i.e., "big data" as it is called nowadays, is still relatively limited in clinical practice. Hilkka Soininen, professor of neurology at the University of Eastern Finland, says: "The innovation of the project is to test the decision-making tool for the detection and differentiation of memory diseases at earliest phases. Detecting signs of progressive memory disease in time will allow earlier interventions and treatments. Tools which support decision-making will be common into tomorrow’s clinical practice. These tools can help a clinician to extract the most important information and profiles among the multitude of data.”

Dementia is a health priority in Europe. Alzheimer's disease alone accounts for costs equivalent to about 1% of the gross domestic product (GDP) of the whole world and the number of persons affected will double in the next 20 years. Alzheimer's disease affects more than five million people in Europe.

Partners
The PredictND research consortium is formed of eight top-level research, academic, industrial and medical organizations from five different European countries: VTT Technical Research Centre of Finland, GE Healthcare (UK), Imperial College London (UK), the University of Eastern Finland, Rigshospitalet (Denmark), VU Medical Center Amsterdam (the Netherlands), the University of Perugia (Italy) and Alzheimer Europe (Luxembourg).

The project will run for four years with a total budget of €4,219,646, to which the EU will contribute €3,148,000.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More Than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

VTT Printed a Morphine Test on Paper
Company use antibodies as morphine sensing molecules when creating this morphine test.
Saturday, April 18, 2015
Novel Cancer Cell DNA Damage Repair Mechanism
Findings result from application of the cell microarray screening method developed at VTT.
Monday, December 23, 2013
International Prize for VTT's Allergy Vaccine Development Work
First vaccines to be ready for launch in about five years.
Monday, December 09, 2013
Powerful Enzymes Create Ethanol from Agricultural Harvest Waste
The mainly EU-funded DISCO project coordinated by VTT Technical Research Centre of Finland has developed powerful enzymes, which accelerate plant biomass conversion into sugars and further into products such as bioethanol.
Wednesday, January 09, 2013
Method Developed by VTT Targets Diagnosis of Early Alzheimer’s Disease
Half of patients could be diagnosed a year earlier than current clinical practice.
Friday, December 07, 2012
Food Industry’s High-Quality Co-Streams Used Effectively as Raw Material for New Products
Researchers develop new ways of using substantial co-streams from fish and oil plant processing.
Tuesday, August 14, 2012
VTT and GE Healthcare Developing Novel Biomarkers to Predict Alzheimer’s Disease
VTT and University of Eastern Finland scientists have discovered a serum biochemical signature.
Wednesday, June 27, 2012
Heparin-like Compounds Inhibit Breast Cancer Metastasis to Bone
Heparin-like compounds decreased bone destruction and tumor growth in bone.
Friday, June 15, 2012
VTT Identified Specific Bacteria which Precede Autoimmune Diabetes
New potential avenues for early disease detection and prevention.
Friday, October 28, 2011
Finnish Twin Study Yields New Information on How Fat Cells Cope With Obesity
The team used lipidomics to study the fat tissue biopsies among several sets of monozygotic twins.
Friday, July 29, 2011
One Step Closer to a Diagnostic Test for Schizophrenia
Scientists in Finland have revealed metabolic abnormalities that are associated with schizophrenia.
Thursday, April 14, 2011
VTT is Searching for New Drug Targets for Prostate Cancer in the New IMI PREDECT Project
PREDECT, one of IMI’s new projects, is developing novel models for breast, prostate and lung cancers.
Monday, April 04, 2011
New Potential Drug Targets Discovered for Preventing Prostate Cancer Cell Growth
Researchers from VTT Technical Research Centre of Finland and the University of Turku have discovered four metabolic enzymes regulating prostate cancer cell growth.
Friday, February 18, 2011
Zora Biosciences Commercializes VTT's Biotechnology Expertise
Zora will provide laboratory services to pharmaceutical industry in the area of metabolomics and associated bioinformatics.
Wednesday, June 27, 2007
VTT Develops Software Tool to Integrate and Analyze Complex Medical Data
The megNet® software can be applied in understanding complex relations in living organisms, and characterizing various diseases, such as cardiac diseases and diabetes.
Friday, April 27, 2007
Scientific News
Point of Care Diagnostics - A Cautious Revolution
Advances in molecular biology, coupled with the miniaturization and improved sensitivity of assays and devices in general, have enabled a new wave of point-of-care (POC) or “bedside” diagnostics.
Mass Spec Technology Drives Innovation Across the Biopharma Workflow
With greater resolving power, analytical speed, and accuracy, new mass spectrometry technology and techniques are infiltrating the biopharmaceuticals workflow.
One Step Closer to Precision Medicine for Chronic Lung Disease Sufferers
A study led by University of North Carolina at Chapel Hill, and National Jewish Health, has provided evidence of links between SNPs and known COPD blood protein biomarkers.
Charles River Acquires Agilux
Enhances Charles River’s early-stage capabilities in bioanalytical services.
Scientists Find Lethal Vulnerability in Treatment-Resistant Lung Cancer
The study describes how the drug Selinexor killed lung cancer cells and shrank tumors in mice when used against cancers driven by the aggressive and difficult-to-treat KRAS cancer gene.
How Baby’s Genes Influence Birth Weight And Later Life Disease
The large-scale study could help to target new ways of preventing and treating these diseases.
Genes Underlying Dogs’ Social Ability Revealed
The social ability of dogs is affected by genes that also seem to influence human behaviour, according to a new study from Linköping University in Sweden.
‘Cellbots’ Chase Down Cancer, Deliver Drugs Directly to Tumors
Programmable T cells shown to be versatile, precise, and powerful in lab studies.
Drug to Treat Alcohol Use Disorder Shows Promise Among Drinkers With High Stress
The findings suggest that potential future studies with drugs targeting vasopressin blockade should focus on populations of people with AUD who also report high levels of stress.
C Dots Show Powerful Tumor Killing Effect
Nanoparticles known as Cornell dots, or C dots, have shown great promise as a therapeutic tool in the detection and treatment of cancer.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!