Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Statins Slow the Progression of Advanced MS in Clinical Trial

Published: Friday, March 21, 2014
Last Updated: Friday, March 21, 2014
Bookmark and Share
The work is published in the Lancet.

Statins may provide doctors with an unlikely new weapon with which to slow the progression of multiple sclerosis (MS).

No treatments can currently abate the advanced stage of the disease, known as secondary progressive MS, which gradually causes patients to become more disabled.

In a two-year clinical trial involving 140 patients with secondary progressive MS, the drug simvastatin slowed brain shrinkage, which is thought to contribute to patients' impairments. Supporting this finding, patients on simvastatin achieved better scores on movement tests and questionnaires that assess disability than patients taking a placebo.

MS is a neurological condition that affects around 2.3 million people worldwide. Most patients are initially diagnosed with relapsing-remitting MS, which causes periodic attacks.

Around 65 per cent of people with relapsing remitting MS develop secondary progressive MS within 15 years of being diagnosed. The secondary progressive phase is where MS has the most personal and societal costs.

The authors of the new study, which was led by Imperial College London, said the findings were very encouraging, but would need to be replicated in a larger trial.

"At the moment, we don't have anything that can stop patients from becoming more disabled once MS reaches the progressive phase," said Dr Richard Nicholas, co-author of the study from the Department of Medicine at Imperial. "Discovering that statins can help slow that deterioration is quite a surprise. This is a promising finding, particularly as statins are already cheap and widely used.

"We need to do a bigger study with more patients, possibly starting in the earlier phase of the disease, to fully establish how effective it is," he added.

Dr Nicholas ran the trial with Dr Jeremy Chataway, then in the Department of Medicine at Imperial and now at University College London.

Statins are taken by millions of people to lower cholesterol and prevent heart disease, but it's unclear why they would have a beneficial effect on MS.

Some small studies have found a small benefit from statins in relapsing remitting MS, which is more treatable.

Secondary progressive MS has proven more challenging to alleviate. In 2013, cannabis became the latest drug to prove unsuccessful at slowing the progression of MS in a clinical trial.

This clinical trial is the culmination of long-standing research led by Professor John Greenwood at the UCL Institute of Ophthalmology showing the potential therapeutic benefits of using statins to treat autoimmune diseases such as multiple sclerosis and uveitis.

Professor Greenwood said, "After nearly two decades of research, it is immensely gratifying to see this work progress into the clinic to deliver benefits to patients."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More Than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

The Brain on LSD: New Scans Show How the Drug Affects the Brain
Researchers at Imperial College London have visualised the effects of LSD on the brain.
Tuesday, April 12, 2016
Cost of Diabetes Hits 825 Billion Dollars a Year
The global cost of diabetes is now 825 billion dollars per year, according to the largest ever study of diabetes levels across the world.
Thursday, April 07, 2016
World's Obese Population Hits 640 Million
More than one in ten men and one in seven women across the globe are now obese, according to the world's biggest obesity study.
Friday, April 01, 2016
Interactive Maps Reveal Global Obesity
World’s obese population hits 640 million, according to largest ever study.
Friday, April 01, 2016
Switching Off Cancers' Ability to Spread
A key molecule in breast and lung cancer cells can help switch off the cancers' ability to spread around the body.
Tuesday, March 22, 2016
Bacterial Motors Unveiled
Nanoscopic 3D imaging has revealed how different bacteria have geared their tiny propeller motors for a wide range of swimming abilities.
Thursday, March 17, 2016
New App Advises and Reminds Pregnant Women About Vaccinations
Researchers at Imperial College London have developed a new app to guide and remind pregnant women about vaccines recommended during pregnancy.
Saturday, March 12, 2016
Infant Milk Formula Does Not Reduce Risk of Eczema and Allergies, Says New Study
Researchers at Imperial College London have found a type of baby formula does not reduce allergy risk - despite previous claims to the contrary.
Wednesday, March 09, 2016
Too Many Avoidable Errors in Patient Care, Says Report
Researchers at Imperial College London have launched the reports in which provide evidence on the current state of patient safety and how it could be improved the future.
Tuesday, March 08, 2016
Big and Small Numbers are Processed in Different Sides of the Brain
Researchers at Imperial College London have suggested that the small numbers are processed in the right side of the brain, while large numbers are processed in the left side of the brain.
Saturday, March 05, 2016
Fossil Find Reveals Just How Big Carnivorous Dinosaur May Have Grown
Researchers at imperial college London have said that an unidentified fossilised bone in a museum has revealed the size of a fearsome Abelisaur and may solve a hundred-year-old puzzle.
Tuesday, March 01, 2016
Bee Brains as You Have Never Seen them Before
Researchers at Imperial College London have found in new study that the Bumblebee brains in unprecedented detail using new techniques in micro-CT imaging.
Thursday, February 25, 2016
Iron in the Blood Could Cause Cell Damage
Concentrations of iron similar to those delivered through standard treatments can trigger DNA damage within 10 minutes, when given to cells in the laboratory.
Friday, February 12, 2016
Head Injury Patients have Protein Clumps Associated with Alzheimer’s Disease
Scientists have revealed that protein clumps associated with Alzheimer's disease are also found in the brains of people who have had a head injury.
Wednesday, February 10, 2016
Exposure to Air Pollution 30 Years Ago Associated with Increased Risk of Death
Exposure to air pollution more than 30 years ago may still affect an individual's mortality risk today, according to new research from Imperial College London.
Wednesday, February 10, 2016
Scientific News
Improving Natural Killer Cancer Therapy
Vanderbilt University researchers discover transcription factor critical for NK cell expansion. Findings could lead to increased therapeutic efficacy.
Molecular Mechanism For Generating Specific Antibody Responses Discovered
Study could spur more ways to treat autoimmune disease, develop accurate vaccines.
Monovar Drills Down Into Cancer Genome
Rice, MD Anderson develop program to ID mutations in single cancer cells.
It’s Now Easier To Go With The Flow
Rice University tool simplifies comparison of flow cytometry data for laboratories.
Autism and Cancer Share a Remarkable Number of Risk Genes
Researchers with the UC Davis Comprehensive Cancer Center, MIND Institute identify more than 40 common genes.
Number Of Known Genetic Risk Factors For Endometrial Cancer Doubled
An international collaboration of researchers has identified five new gene regions that increase a woman’s risk of developing endometrial cancer, one of the most common cancers to affect women, taking the number of known gene regions associated with the disease to nine.
Genetic Variant May Help Explain Why Labradors Are Prone To Obesity
A genetic variation associated with obesity and appetite in Labrador retrievers – the UK and US’s favourite dog breed – has been identified by scientists at the University of Cambridge. The finding may explain why Labrador retrievers are more likely to become obese than dogs of other breeds.
FNIH Launches Project to Evaluate Biomarkers in Cancer Patients
Company has announced that it has launched a new project to evaluate the effectiveness of liquid biopsies as biomarkers in colorectal cancer patients.
Flowering Regulation Mechanism Discovered
Monash researchers have discovered a new mechanism that enables plants to regulate their flowering in response to raised temperatures.
Turning Skin Cells into Heart, Brain Cells
In a major breakthrough, scientists at the Gladstone Institutes transformed skin cells into heart cells and brain cells using a combination of chemicals.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!