Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

InSphero Announces Collaboration with NCATS

Published: Friday, March 21, 2014
Last Updated: Friday, March 21, 2014
Bookmark and Share
Study to characterize 460 NCATS anti-cancer agents in 3D tumor models generated using InSphero technology.

InSphero AG announced a collaboration with the National Institutes of Health's (NIH) National Center for Advancing Translational Sciences (NCATS) to identify anti-cancer agents with cytotoxic activity in 3D culture models. The project includes development of multi-cell type spheroids (MCTS) by InSphero in the company's 96- and 384-well GravityPLUS hanging drop plates, using tumor cell lines currently being at NCATS. InSphero will generate the 3D microtissues and provide them to NCATS to screen a collection of 460 anti-cancer agents for cytotoxic effects using assays that measure cell proliferation, tissue integrity, and tissue size. 

In the study, MCTS cultures will be explored as a model of tumors to predict the effectiveness of anti-cancer drugs. Currently, high-throughput screens to discover such agents are typically conducted in two dimensional (2D) proliferation assays using cells grown on tissue-culture treated plastic surfaces. However, it is evident that such 2D assays using cancer cell lines fail to reproduce the cellular heterogeneity of tumors, as well as the complexity of the interactions with the tumor microenvironment that are seen in viva As a consequence, compounds that appear to be cytotoxic in 2D cell proliferation assays often fail to produce an effect in vivo. 

The 3D microtissues are thought to offer a more accurate physiological representation of a tumor and its extracellular environment, including the effect of additional cell types such as endothelial and stromal cells. 3D cultures are also being used as models to investigate tumor cell sub-populations called cancer stem cells or tumor-initiating cells. These cells have self-renewal potential and are thought to drive metastasis and tumor formation. They also appear to be resistant to current chemotherapy and radiation-therapy treatments that produce cancer recurrence. 

"InSphero is excited to join forces with the expertise and resources from the NCATS team to help screen their oncology library for compounds that can kill cancer cells in the context of a more relevant tumor model system," says Jens Kelm, Ph.D., Chief Scientific Officer and co-founder of InSphero. "By co-culturing non-proliferative stromal cells in combination with tumor cell lines, the 3D spheroids more accurately reflect tumor heterogeneity and tumor microenvironments. Our system will enable direct discrimination of compounds that act specifically on the cancer cell population from those having a general cytotoxic effect." 

"Our work with InSphero is yet another example of how NCATS fosters collaborations to explore novel technologies that carry the promise to accelerate discovery of molecular therapeutic agents across multiple disease areas," said Anton Simeonov, Ph.D., acting deputy scientific director of NCATS' Division of Pre-Clinical Innovation.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,900+ scientific posters on ePosters
  • More Than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

InSphero Expands Global Availability of its Patented 3D Cell Culture Platforms
PerkinElmer named as exclusive distributor of InSphero 3D culture technology.
Thursday, August 06, 2015
InSphero AG Secures CHF 20 Million Series C Financing
3D cell culture company gains new long-term investor to fuel expansion of global operations and product portfolio.
Wednesday, July 15, 2015
InSphero AG Secures CHF 20 Million Series C Financing
Leading 3D cell culture company gains new long-term investor to fuel expansion of global operations and product portfolio.
Tuesday, July 14, 2015
3D Liver Spheroid Model in Use by MIP-DILI
European consortium will use 3D liver tissues to better predict drug-induced liver injury.
Friday, January 23, 2015
InSphero Wins ACES Award as Top European Academic Enterprise in Life Sciences
Second honor in three weeks continues momentum for leading supplier of 3D microtissues for in vitro toxicity and efficacy testing.
Wednesday, October 15, 2014
InSphero Named #1 Swiss Startup for 2014
Leading supplier of 3D microtissues for in vitro toxicity and efficacy testing earns top honors in annual Swiss startup competition.
Saturday, October 04, 2014
InSphero Publishes 3D Tumor-Stroma Model for Non-Small Cell Lung Cancer
PLOS One article delivers promising co-culture method to mimic tumor microenvironment, demonstrating potential for biomarker and drug discovery.
Thursday, April 24, 2014
InSphero Hires New Director of Global Marketing
Randy Strube, Ph.D. joins company to strengthen InSphero's marketing team.
Thursday, January 30, 2014
Scientific News
Big Genetics in BC: The American Society for Human Genetics 2016 Meeting
Themes at this year's meeting ranged from the verification, validation, and sharing of data, to the translation of laboratory findings into actionable clinical results.
Stem Cells in Drug Discovery
Potential Source of Unlimited Human Test Cells, but Roadblocks Remain.
Cancer Genetics: Key to Diagnosis, Therapy
When applied judiciously, cancer genetics directs caregivers to the right drug at the right time, while sparing patients of unnecessary or harmful treatments.
BGI Sequences Gingko Tree, Revealing Large, Highly Repetitive Genome
Researchers at BGI have sequenced the more than 10-gigabase ginkgo genome to find a high number of repetitive sequences as well as a number of gene clusters that appear to be involved in defense mechanisms.
Survey of New York City Soil Uncovers Medicine-Making Microbes
Microbes have long been an invaluable source of new drugs. And to find more, we may have to look no further than the ground beneath our feet.
Accelerating the Detection of Foodborne Bacterial Outbreaks
The speed of diagnosis of foodborne bacterial outbreaks could be improved by a new technique developed by researchers at the Georgia Institute of Technology.
Making Personalized Medicine a Reality
Groundbreaking technique developed at McMaster University is helping to pave the way for advances in personalized medicine.
Scientists Identify Unique Genomic Features in Testicular Cancer
The findings may shed light on factors in other cancers that influence their sensitivity to chemotherapy.
Top 10 Life Science Innovations of 2016
2016 has seen the release of some truly innovative products. To help you digest these developments, The Scientist have listed their top picks for the year.
BioCision Forms MedCision
The new company will focus on technologies for the management and automation of vital clinical processes.
Scroll Up
Scroll Down
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!