Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Insight into the Transport Systems of Cells

Published: Monday, March 24, 2014
Last Updated: Monday, March 24, 2014
Bookmark and Share
The insights into the basic operation of cells was achieved using a combination of advanced live-cell imaging, molecular genetics and quantitative analysis.

Research led by Gero Steinberg, Professor of Cell Biology and Director of the Bioimaging Centre at the University of Exeter, features in both the latest editions of the Journal of Cell Biology 

Professor Steinberg and his colleagues have investigated how cells undertake long range transport within polarised cells, such as those in the nervous system of humans.  Speaking about the research, Professor Steinberg said “ We want to understand how cells can transport and distribute cargo within cells.  This is vital if we are to understand how nerve cells operate, for instance, or how pathogenic fungi are able to cause diseases".

Cells have transport networks composed of long microtubules that act like motorways for long distance transport, which uses special motor proteins to delivery cargo to different parts of cells, such as the nucleus, organelles, or for secretion outside of a cell.  Prof. Steinberg has used the model fungusUstilago mayidis to identify the how motor proteins are regulated so they can carry out transport in opposite directions along microtubules. 

In the latest article, the researchers found that a special protein called ‘Hook’ controls the attachment of two different motors, dynein and kinesin-3, to cargo, thereby controlling the transport direction of the organelles. Hook proteins have previously been implicated in numerous human diseases, but the reason for this was unknown.  The Exeter research now reveals why they are so important in the operation of neurons and cells within the brain.

Speaking about the research, Professor Nick Talbot, Deputy Vice-Chancellor for Research said: “This research is impressive because it integrates the latest advances in bio-imaging so we can look at the operation of motor proteins in living cells in un-paralleled detail.  Prof. Steinberg’s group then collaborate with mathematicians to model the movement and activity of these motors and their key regulators, such as Hook.  It is this combination of skills which allows such important and fundamental new discoveries to be made.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,100+ scientific posters on ePosters
  • More Than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Vaccine Could Save Thousands of Lives
Work led by University of Exeter experts could help to protect thousands of people from an often fatal disease found in most tropical regions.
Wednesday, March 02, 2016
Easier Diagnosis for Fungal Infection of the Lungs
A new clinical imaging method developed in collaboration with a University of Exeter academic may enable doctors to tackle one of the main killers of patients with weakened immune systems sooner and more effectively.
Tuesday, January 26, 2016
Genetics Reveals Patients Susceptible to Drug-induced Pancreatitis
Doctors have discovered that patients with a particular genetic variation are four times more likely to develop pancreatitis if they are prescribed a widely used group of drugs.
Friday, September 19, 2014
Fruit Fly Cells Offer Cancer Insights
Researchers at the University of Exeter have shown that cells demonstrate remarkable flexibility and versatility when it comes to how they divide.
Friday, January 03, 2014
Spread of Crop Pests Threatens Global Food Security as Earth Warms
A new study has revealed that global warming is resulting in the spread of crop pests towards the North and South Poles at a rate of nearly 3 km a year.
Friday, September 06, 2013
Scientific News
The Rise of 3D Cell Culture and in vitro Model Systems for Drug Discovery and Toxicology
An overview of the current technology and the challenges and benefits over 2D cell culture models plus some of the latest advances relating to human health research.
Grant Supports Project To Develop Simple Test To Screen For Cervical Cancer
UCLA Engineering announces funding from Bill and Melinda Gates Foundation.
Injecting New Life into Old Antibiotics
A new fully synthetic way to make a class of antibiotics called macrolides from simple building blocks is set to open up a new front in the fight against antimicrobial drug resistance.
Insight into Bacterial Resilience and Antibiotic Targets
Variant of CRISPR technology paired with computerized imaging reveals essential gene networks in bacteria.
Advancing Protein Visualization
Cryo-EM methods can determine structures of small proteins bound to potential drug candidates.
Alzheimer’s Protein Serves as Natural Antibiotic
Alzheimer's-associated amyloid plaques may be part of natural process to trap microbes, findings suggest new therapeutic strategies.
Slime Mold Reveals Clues to Immune Cells’ Directional Abilities
Study from UC San Diego identifies a protein involved in the directional ability of a slime mold.
How Do You Kill A Malaria Parasite?
Drexel University scientists have discovered an unusual mechanism for how two new antimalarial drugs operate: They give the parasite’s skin a boost in cholesterol, making it unable to traverse the narrow labyrinths of the human bloodstream. The drugs also seem to trick the parasite into reproducing prematurely.
Illuminating Hidden Gene Regulators
New super-resolution technique visualizes important role of short-lived enzyme clusters.
Supressing Intenstinal Analphylaxis in Peanut Allergy
Study from National Jewish Health shows that blockade of histamine receptors suppresses intestinal anaphylaxis in peanut allergy.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,100+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!