Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Adaptimmune Awarded £2.1m from the Biomedical Catalyst Fund

Published: Tuesday, March 25, 2014
Last Updated: Tuesday, March 25, 2014
Bookmark and Share
The prestigious award supports Adaptimmune’s clinical pipeline expansion.

Adaptimmune today announced that it has been awarded a grant of £2.1 million from the Biomedical Catalyst Fund, managed by the UK’s innovation agency the Technology Strategy Board and the Medical Research Council. The prestigious award will expedite the development of Adaptimmune’s second engineered T cell therapy programme into the clinic in triple negative breast cancer.
Adaptimmune engineers patients’ T lymphocytes to target and kill cancer cells when re-infused into the body. Its approach is focused on engineering increased affinity T cell receptors (TCR), the molecules on the surface of cytotoxic T lymphocytes that are naturally designed to recognize cancer cells. The company already has one T cell receptor programme in multiple cancer trials in the USA, with promising initial results.

The funding award will be used to expedite Adaptimmune’s second clinical programme with a new TCR to enter the clinic in the UK. The award will support preclinical testing and regulatory approval for an initial pilot trial with a new TCR targeting an undisclosed protein found to be highly expressed in some forms of breast cancer and other cancer types. The trial is planned to start in 2015.

David Willetts, Minister for Universities and Science, said: “Britain has a world-leading life science cluster and Adaptimmune is a classic example of an innovative bioscience company that the Biomedical Catalyst Fund is designed to support. Its personalized therapy for cancer developed over 15 years in Oxford represents a potential breakthrough in cancer treatment for thousands of patients.”

Adaptimmune’s unique approach relies on the ability to fine-tune the affinity of the T cells to recognize the small protein fragments from intracellular cancer-specific proteins presented on the cell surface. This novel class of cancer targets cannot be bound by antibodies or chimeric antigen receptor T cells and natural affinity T cell receptors fail to bind effectively to cause a killing response. Adaptimmune has a pipeline of T cell receptors recognizing such targets and the funding award comes at a time when the company is significantly increasing its activities in the UK as well as the USA.

James Noble, Adaptimmune’s Chief Executive Officer, said: “We are delighted to be announcing the Biomedical Catalyst Fund support for our next pipeline TCR and its path towards the clinic in 2015. We have a wide portfolio of cancer targets to be exploited in this way and our objective is to develop this pipeline of TCRs as rapidly as possible for the benefit of patients.”

Dr Bent Jakobsen, Adaptimmune’s co-founder and Chief Scientific Officer, said: “The ability of T cells to track down and kill cancer cells is one of the most powerful weapons we can bring to bear on the disease. We have spent 15 years optimizing and testing T cell receptors here in the UK and the award from the Biomedical Catalyst Fund provides an important boost to expand the pipeline for the benefit of UK patients.”

Grants from the UK government-backed Biomedical Catalyst Fund totalling more than £120 million have been awarded to over 100 projects since the grant programme was introduced in 2012. The projects are led by UK-based small and medium-sized businesses and universities to accelerate the development of innovative solutions to healthcare challenges. Adaptimmune represents one of the companies which have benefitted to date from the £180 million Biomedical Catalyst fund, a programme of public funding jointly managed by the Technology Strategy Board and the Medical Research Council. 

Adaptimmune’s existing clinical programme targets a peptide from two cancer testis antigens (CT antigens) called NY-ESO-1 and LAGE-1. Both proteins are expressed in multiple cancers and the company is running studies in the US in multiple myeloma, melanoma, synovial sarcoma and ovarian cancer, with its most recent results reported for multiple myeloma at the annual conference of the American Society of Hematology in December 2013. Details of all current clinical studies can be found on clinicaltrials.gov.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More Than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Adaptimmune, GSK Expand Strategic Immunotherapy Collaboration
Adaptimmune Therapeutics and GlaxoSmithKline announced that the companies have expanded the terms of their strategic collaboration agreement to accelerate Adaptimmune’s lead clinical cancer program, an affinity enhanced T-cell immunotherapy (GSK3377794) targeting NY-ESO-1, toward pivotal trials in synovial sarcoma.
Wednesday, February 03, 2016
Adaptimmune, Universal cells Collaborate
The companies have announced that they have entered into a collaboration and exclusive license agreement for the development of allogeneic T cell therapies.
Wednesday, December 02, 2015
Adaptimmune Announces New Research and Development Facility in Oxfordshire
‘Enterprise Zone’ building will house company’s expanding R&D operation.
Wednesday, October 07, 2015
Adaptimmune Expands Trial of T-cell Therapy for Synovial Sarcoma
The company have announced that the first patient has been dosed in its expanded Phase I/II trial of its affinity enhanced T-cell receptor (TCR) therapeutic targeting the NY-ESO-1 cancer antigen in synovial sarcoma patients.
Friday, September 04, 2015
Adaptimmune's Novel Cancer Therapeutics Show Positive Clinical Trial Results
The company has announced that positive data from its Phase I/II study of its affinity enhanced T-cell receptor (TCR) therapeutic targeting the NY-ESO-1 cancer antigen in patients with multiple myeloma has been published.
Tuesday, July 21, 2015
Adaptimmune’s NY-ESO-1 TCR-engineered T-Cells Demonstrate Durable Persistence
Study has been published in Nature Medicine.
Tuesday, July 21, 2015
Adaptimmune Appoints Lawrence M. Alleva to its Board of Directors
Lawrence M. Alleva will join the Board as an independent, non-executive director.
Wednesday, March 11, 2015
Adaptimmune Strengthens Management Team with Key Executive Hires
Adaptimmune has strengthened its senior management team with the appointment of Dr. Rafael Amado, as Chief Medical Officer, and Adrian (Ad) Rawcliffe, as Chief Financial Officer.
Wednesday, March 04, 2015
Adaptimmune Announces Interim Results from Pilot Trial of NY-ESO T Cells
Study reports encouraging response rate and safety profile.
Friday, October 17, 2014
Adaptimmune Secures $104 Million in Series A Financing
Company will use funding to advance programmes in multiple cancer indications.
Friday, September 26, 2014
Adaptimmune Named as One of “Fierce 15” Biotech Companies of 2014
Company has created T-cell receptors which are deployed to target NY-ESO-1.
Tuesday, September 23, 2014
Adaptimmune Announces Full-time Appointment of James Noble as CEO
Appointment will become effective from 31st March.
Thursday, March 27, 2014
Adaptimmune Announces Interim Results from a Phase I/II Trial of Engineered T Cells
Study continues to report encouraging response rates, safety and proof of mechanism.
Thursday, December 12, 2013
Interim Results from Phase I/II Trial of Engineered T Cells Targeting Cancer Testis Antigens in Multiple Myeloma
Adaptimmune announces that study continues to report encouraging response rates, safety and proof of mechanism.
Tuesday, December 10, 2013
Adaptimmune Appoints Chairman of the Board
Dr Jonathan Knowles has been appointed as the new executive Chairman of the Board of Directors with immediate effect.
Thursday, November 21, 2013
Scientific News
Improving Natural Killer Cancer Therapy
Vanderbilt University researchers discover transcription factor critical for NK cell expansion. Findings could lead to increased therapeutic efficacy.
Molecular Mechanism For Generating Specific Antibody Responses Discovered
Study could spur more ways to treat autoimmune disease, develop accurate vaccines.
Monovar Drills Down Into Cancer Genome
Rice, MD Anderson develop program to ID mutations in single cancer cells.
It’s Now Easier To Go With The Flow
Rice University tool simplifies comparison of flow cytometry data for laboratories.
Autism and Cancer Share a Remarkable Number of Risk Genes
Researchers with the UC Davis Comprehensive Cancer Center, MIND Institute identify more than 40 common genes.
Number Of Known Genetic Risk Factors For Endometrial Cancer Doubled
An international collaboration of researchers has identified five new gene regions that increase a woman’s risk of developing endometrial cancer, one of the most common cancers to affect women, taking the number of known gene regions associated with the disease to nine.
Genetic Variant May Help Explain Why Labradors Are Prone To Obesity
A genetic variation associated with obesity and appetite in Labrador retrievers – the UK and US’s favourite dog breed – has been identified by scientists at the University of Cambridge. The finding may explain why Labrador retrievers are more likely to become obese than dogs of other breeds.
FNIH Launches Project to Evaluate Biomarkers in Cancer Patients
Company has announced that it has launched a new project to evaluate the effectiveness of liquid biopsies as biomarkers in colorectal cancer patients.
Flowering Regulation Mechanism Discovered
Monash researchers have discovered a new mechanism that enables plants to regulate their flowering in response to raised temperatures.
Turning Skin Cells into Heart, Brain Cells
In a major breakthrough, scientists at the Gladstone Institutes transformed skin cells into heart cells and brain cells using a combination of chemicals.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!