Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Lab Scale Manufacturing Using Continuous Crystallization

Published: Tuesday, April 15, 2014
Last Updated: Tuesday, April 15, 2014
Bookmark and Share
A new METTLER TOLEDO On-demand webinar explores recent research that could revolutionize pharmaceutical production.

In the webinar, in situ Process Analytical Technology (PAT) supported the development of a continuous plug flow crystallization platform that was able to meet production scale capacities in a lab setting while tightly controlling product attributes including particle size and shape distribution as well as yield and purity.

The Company is pleased to present a new installment in its thought-leading on-demand webinar series on Process Analytical Technology (PAT). The presentation, entitled “PAT-Based Design of Continuous Crystallizations,” explores specific methodology using ParticleTrack with Focused Beam Reflectance Measurement (FBRM) technology and related technologies for rapid plug-flow crystallization evaluation. Experiments using this methodology enabled a significant increase in production volume on lab-scale equipment.

Guest presenter Steven Ferguson, Biogen Idec, Cambridge, Massachusetts, developed the experiment series while working on his PhD as part of the Glennon Research Group (SSPC) at University College, Dublin. He also spent time at Novartis/ MIT Center for Continuous Manufacturing and Department of Chemical Engineering, as a post-doctoral associate with a focus on continuous crystallization, isolation and polymorphism.

A plug flow crystallization platform was developed that allowed PAT to be applied in situ via the use of novel flow cells to develop the anti-solvent crystallization of benzoic acid from aqueous ethanol solution. Equivalent tank-based MSMPR crystallizations using a pneumatic slurry transfer were also characterized using PAT. Both methods were then compared to equivalent batch crystallizations to gain their true performance measure.

As expected, continuous crystallization offered significantly intensified production, with approximately the same material generated by ~33 ml plug flow, 9 L MSMPR, and 42, 10,000 L batch crystallizations per annum. Furthermore, non-batch processing enabled production of a wider range of particle sizes and morphologies, with plug flow generating the highest possible supersaturation when feed and anti-solvent streams were perfectly mixed.

Despite its relatively small volume, under optimum conditions the plug flow device proved capable of producing 60 kilos a day of dry, isolated benzoic acid, providing production-scale pharmaceutical development with lab-scale equipment. Screening methodologies to determine if plug flow crystallization is appropriate for a particular chemistry is also explored, as is using FBRM and Particle Vision Microscopy (PVM) to monitor and maximize operating conditions.



Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More Than 4,600+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

METTLER TOLEDO Announces a New Symposium on Process Chemistry and Scale-Up
Company has announced that the discover methods entitled Process Chemistry and Scale-up Online Seminar featuring R&D scientists from Air Products and Nalas Engineering.
Wednesday, March 16, 2016
The Art of Pipetting
Sculptor and installation artist Mitra Fabian has created an iceberg sculpture made from recycled pipette tips.
Friday, February 05, 2016
13 Ways to Stop an Unseen Force from Disrupting Weighing
Download a free Mettler Toledo paper to discover how to halt static’s negative effects before the next weigh-in.
Saturday, October 03, 2015
Mettler-Toledo Awarded Foreign Designated Manufacturer Certification
Mettler Toledo is the first balance manufacturer to win FDM certification in Japan.
Friday, July 26, 2013
Free Webinar Explores Safe Scaling of Pressure Reactions
Robust in situ technology allows cost effective scale-up pressure reactions.
Friday, May 24, 2013
Pharma Tech Trends and Development Cost Solutions
METTLER TOLEDO’s new on-demand webinar, “Methods to Improve Chemical Process Development,” takes on the challenges of today’s pharmaceutical market.
Thursday, April 04, 2013
Mettler-Toledo and Konica Minolta Join Forces
Strategic partnership in the field of multi-parameter analysis for the Flavours & Fragrances industry.
Friday, May 18, 2012
Scientific News
Platelets are the Pathfinders for Leukocyte Extravasation During Inflammation
Findings from the study could help in the prevention and treatment of inflammatory pathologies.
ASMS 2016: Targeting Mass Spectrometry Tools for the Masses
The expanding application range of MS in life sciences, food, energy, and health sciences research was highlighted at this year's ASMS meeting in San Antonio, Texas.
Benchtop Automation Trends
Gain a better understanding of current interest in and future deployment of benchtop automated systems.
Some Women With PCOS May Have Adrenal Disorder
Researchers at NIH have found that a subgroup of women with polycystic ovary syndrome (PCOS), a leading cause of infertility, may produce excess adrenal hormones.
Alzheimer's Genetics Point To New Research Direction
A University of Adelaide analysis of genetic mutations which cause early-onset Alzheimer’s disease suggests a new focus for research into the causes of the disease.
Penn State, TB Alliance, and GSK Partner To Discover New Treatments For TB
A new collaboration between TB Alliance, GSK, and scientists in the Eberly College of Science seeks to find new small molecules that can be used to create antibiotics in the fight against tuberculosis (TB).
Manufactured Stem Cells To Advance Clinical Research
Clinical-grade cell line will enable development of new therapies and accelerate early-stage clinical research.
How Cancer Spreads in the Body
Cancer cells appear to depend on an unusual survival mechanism to spread around the body, according to an early study led by Queen Mary University of London.
Fix for 3-Billion-Year-Old Genetic Error
Researchers at The University of Texas at Austin have developed a fix that allows RNA to accurately proofread for the first time.
“Amazing Protein Diversity” Discovered in Maize
The genome of the corn plant – or maize, as it’s called almost everywhere except the US – “is a lot more exciting” than scientists have previously believed. So says the lead scientist in a new effort to analyze and annotate the depth of the plant’s genetic resources.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,600+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!