Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Lab-on-a-Chip Device Overcomes Miniaturisation Problems

Published: Thursday, May 01, 2014
Last Updated: Thursday, May 01, 2014
Bookmark and Share
The novel technique involves printing a pattern of miniscule droplets of a special solvent onto a gold-coated or glass surface.

UNSW chemists have invented a new type of tiny lab-on-a-chip device that could have a diverse range of applications, including to detect toxic gases, fabricate integrated circuits and screen biological molecules.

 “We use a class of ‘green’ solvents called ionic liquids, which are salts that are liquid at room temperature.  They are non-volatile, so this overcomes one of the main problems in making useful miniaturised devices - rapid evaporation of the solvents on the chip,” says Dr Chuan Zhao, senior author of the study.

“The versatility of our chips means they could have a wide range of prospective functions, such as for use in fast and accurate hand-held sensors for environmental monitoring, medical diagnosis and process control in manufacturing.”

The research is published in the journal Nature Communications. It was carried out by Dr Zhao, Christian Gunawan and Mengchen Ge from the UNSW School of Chemistry.

Lab-on-a- chip devices, where chemical reactions are carried out on a miniature scale, are under intensive development because they offer the promise of faster reaction times, reduced use of materials and high yields of product.

Evaporation of solvents on the chip, however, is a big problem because this can affect the concentration of substances and disrupt the reactions. Attempted solutions include containing the solvents within tiny channels or “walls”, and having reservoirs to store extra solvent on the chip.

The “wall-less” design developed by the UNSW team - using non-volatile ionic liquids as solvents to fabricate a microarray of droplets chemically anchored to the chip - has several significant advantages.

“Ionic liquids are designer solvents and have wide application. We can now carry out many reactions or analytical procedures in ionic liquids at the micro-scale on a chip with enhanced yields and efficiency,” says Dr Zhao.

“These microarray chips can be easily produced in high numbers and are very stable. They can survive being turned upside down and heated to 50 degrees and some can even survive being immersed in another liquid. These properties will be important for commercial applications, including storage and transportation of microchips.”

The droplets of ionic liquid are about 50 micrometres across (about half the width of a human hair) and 10 micrometres high.

The UNSW researchers demonstrated several potential uses of the microarrays.

They showed the tiny droplets can act as rapid, sensitive monitors of the presence of a gas, due to their small volume.

They also demonstrated that metal salts dissolved in the droplets could be electrically deposited as microstructures, a technique which could be of use in fabrication of integrated circuits.

Some biological molecules added to the droplets also remained stable and active, opening up the possibility of using the microarrays for diagnostic purposes.



Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More Than 4,400+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Apricot Kernels Pose Risk of Cyanide Poisoning
Eating more than three small raw apricot kernels, or less than half of one large kernel, in a serving can exceed safe levels. Toddlers consuming even one small apricot kernel risk being over the safe level.
Cell Transplant Treats Parkinson’s in Mice
A University of Wisconsin—Madison neuroscientist has inserted a genetic switch into nerve cells so a patient can alter their activity by taking designer drugs that would not affect any other cell.
Understanding Female HIV Transmission
Glowing virus maps points of entry through entire female reproductive tract for first time.
Genetic Markers Influence Addiction
Differences in vulnerability to cocaine addiction and relapse linked to both inherited traits and epigenetics, U-M researchers find.
Lab-on-a-Chip for Detecting Glucose
By integrating microfluidic chips with fiber optic biosensors, researchers in China are creating ultrasensitive lab-on-a-chip devices to detect glucose levels.
A lncRNA Regulates Repair of DNA Breaks in Breast Cancer Cells
Findings give "new insight" into biology of tough-to-treat breast cancer.
COPD Linked to Increased Bacterial Invasion
Persistent inflammation in COPD may result from a defect in the immune system that allows airway bacteria to invade deeper into the lung.
Detection of HPV in First-Void Urine
Similar sensitivity of HPV test on first void urine sample compared to cervical smear.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,400+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!