Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

Biodesign Institute, Thermo Fisher Partner on $9M Radiation Test

Published: Wednesday, June 04, 2014
Last Updated: Wednesday, June 04, 2014
Bookmark and Share
Partnership enters a new, $9M phase of a project to produce a diagnostic test to rapidly measure an individual’s level of absorption of ionizing radiation.

The project is part of a potential $31.2 million in total funds authorized by the Biomedical Advanced Research and Development Authority (BARDA), a federal agency within the Office of the Assistant Secretary for Preparedness and Response of the U.S. Department of Health and Human Services. The project is a collaboration with Life Sciences Solutions at Thermo Fisher Scientific and utilizes the Life Technologies brand of qPCR (quantitative polymerase chain reaction) instruments for analysis of gene expression.

“We are proud to be moving forward in this ambitious, challenging project that combines ASU’s considerable research strengths in biomarkers with Thermo Fisher’s expertise in the product commercialization process,” said Joshua LaBaer, director of the Biodesign Institute’s Virginia G. Piper Center for Personalized Diagnostics.  “Our research team’s ultimate goal is to translate our discoveries for development of an automated high-throughput system for radiation biodosimetry that is capable of processing a high volume of blood samples per day for gene expression analysis.”

“We are very pleased that our colleagues at Arizona State University selected the Life Technologies brand of qPCR instruments for this important work to protect public safety,” said Chris Linthwaite, head of Genetic Systems Division, Research Platforms at Thermo Fisher. “The project represents a novel approach to deliver fast and accurate measures of absorbed radiation using molecular detection technology.” 

Currently, no rapid, FDA cleared high-throughput system exists to measure the radiation dose absorbed by individuals within a large population. Of the eleven project teams launched in 2010, the ASU group is one of six continuing development of a medical device to address this application.

The Biodesign Institute at ASU is designing a multi-gene assay panel and collaborating with Thermo Fisher to develop a real-time quantitative PCR-based assay system to rapidly assess absorbed radiation dose.  The Project is entering a $9M contract option to optimize the biomarker assay and platform workflow to prepare for testing needed to seek regulatory clearance for the assay from the U.S. Food and Drug Administration.

According to members of the ASU Biodesign Institute team, Thermo Fisher will lead the FDA submission process for the assay panel utilizing its PCR platforms that are currently listed with the FDA.

“As part of the project, the Biodesign Institute has developed a high-quality, biomarker discovery core competency utilizing next generation sequencing and gene selection algorithms that can reproducibly identify and select biomarkers.  Our process includes quality control standards and can be applied to many other medical challenges for research, diagnosis or development of a therapeutic,” said Kristin Gillis, senior scientific project manager.  

Collaborators to the team, along with Biodesign Institute biomarker research expert Dr. Joshua LaBaer, director of the institute’s Virginia G. Piper Center for Personalized Diagnostics, include Sally Amundson, PhD, at Columbia University Medical Center, who has extensive experience in researching radiation responsive genes, and ASU’s strategic partnership with Mayo Clinic, where Dr. William Wong will provide critical access to patient clinical samples needed for biomarker development. 

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More Than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Thermo Scientific Gemini Handheld Chemical Analyzer Wins R&D 100 Award
Two-in-one portable device also earns Editor’s Choice in Analytical/Test category for 2015 by R&D Magazine.
Thursday, November 26, 2015
Thermo Scientific Signs Agreement with Novartis and Pfizer
Universal test designed for non-small cell lung cancer supports multiple drug development programs.
Thursday, November 26, 2015
Thermo Scientific Opens New GMP Clinical Services Facility in Singapore
New regional BioPharma Services hub offers larger operational space and advanced equipment to meet increasing clinical supply needs for pharma and biotech customers.
Saturday, November 21, 2015
Thermo Scientific Manufacturing Site to Meet Guidelines for 18385 Certification
A new standard proposed by the International Organization for Standardization.
Thursday, October 15, 2015
Thermo Fisher Scientific Announces Winners of 2016 Winter Conference Awards in Plasma Spectrochemistry
Independent committee recognizes significant contributions in plasma spectrochemistry.
Wednesday, September 23, 2015
Thermo Fisher Scientific Receives IVDD CE Mark for LC-MS Products
Now available to clinical laboratories in Europe for general in vitro diagnostic use.
Friday, September 11, 2015
Thermo Launches Geneticon
Thermo Fisher Scientific launches GenetiCon, a virtual resource showcasing the real-life science behind superheroic powers and more.
Tuesday, July 07, 2015
Thermo Fisher Agrees to Buy Alfa Aesar for $403M
The company announced a definitive agreement to buy the research chemical manufacturer for $403 million.
Friday, June 26, 2015
Ebola Sequencing Data Released to Global Research Community Online
To curb further spread of Ebola in Sierra Leone, a team of scientists that is part of an international, multi-organizational effort has released their first dataset of the virus’ genetic structure online.
Wednesday, June 03, 2015
Thermo's NGS Platform Selected for Nationwide Clinical Research Program
National Cancer Institute-MATCH trial to sequence thousands of tumor samples using Ion Torrent targeted sequencing technology.
Monday, June 01, 2015
Thermo Strengthens Bioprocessing Offering with Advanced Scientifics Acquisition
Thermo Fisher Scientific has acquired Advanced Scientifics, Inc., a global provider of single-use technologies for customized bioprocessing solutions, for $300 million in cash.
Friday, February 06, 2015
Thermo Fisher Q3 Revenues up 31 Percent
Thermo Fisher announced that revenues grew 31% to $4.17 billion for the third quarter ended September 27, 2014.
Thursday, October 23, 2014
Thermo Scientific Announces Listing of the Ion PGM Dx System
Company has completed the listing with the U.S. FDA as class II medical device.
Saturday, September 20, 2014
Thermo Fisher, NRLs Team to Confirm Dioxins in Feed and Food
Thermo Fisher Scientific worked closely with national reference labs (NRLs) in the European Union to support the development of new regulation.
Monday, September 08, 2014
Thermo Completes Sale of Cole-Parmer to GTCR
Thermo Fisher Scientific Inc. announced that it has completed the sale of its Cole-Parmer customer channel business to private equity firm GTCR LLC for approximately $480 million in cash.
Wednesday, August 20, 2014
Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
How a Genetic Locus Protects Adult Blood-Forming Stem Cells
Mammalian imprinted Gtl2 protects adult hematopoietic stem cells by restricting metabolic activity in the cells' mitochondria.
Genetic Basis of Fatal Flu Side Effect Discovered
A group of people with fatal H1N1 flu died after their viral infections triggered a deadly hyperinflammatory disorder in susceptible individuals with gene mutations linked to the overactive immune response, according to a recent study.
New Tech Vastly Improves CRISPR/Cas9 Accuracy
A new CRISPR/Cas9 technology developed by scientists at UMass Medical School is precise enough to surgically edit DNA at nearly any genomic location, while avoiding potentially harmful off-target changes typically seen in standard CRISPR gene editing techniques.
The MaxSignal Colistin ELISA Test Kit from Bioo Scientific
Kit can help prevent the antibiotic apocalypse by keeping last resort drugs out of the food supply.
"Good" Mozzie Virus Might Hold Key to Fighting Human Disease
Australian scientists have discovered a new virus carried by one of the country’s most common pest mosquitoes.
Non-Disease Proteins Kill Brain Cells
Scientists at the forefront of cutting-edge research into neurodegenerative diseases such as Alzheimer’s and Parkinson’s have shown that the mere presence of protein aggregates may be as important as their form and identity in inducing cell death in brain tissue.
Closing the Loop on an HIV Escape Mechanism
Research team finds that protein motions regulate virus infectivity.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Potential Treatment for Life-Threatening Viral Infections Revealed
The findings point to new therapies for Dengue, West Nile and Ebola.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos