Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

‘Liquid Biopsy’ Offers New Way to Track Lung Cancer

Published: Wednesday, June 04, 2014
Last Updated: Wednesday, June 04, 2014
Bookmark and Share
Scientists have shown how a lung cancer patient’s blood sample could be used to monitor and predict their response to treatment.

The recent study, published in the journal Nature Medicine, also offers a method to test new therapies in the lab and to better understand how tumours become resistant to drugs.

Small cell lung cancer (SCLC) is an aggressive disease with poor survival and new treatments are desperately needed. In many cases the tumour is inoperable and biopsies are difficult to obtain, giving scientists few samples with which to study the disease.

Now research carried out at Cancer Research UK’s Manchester Institute, based at The University of Manchester – part of the Manchester Cancer Research Centre – has looked at the potential of using circulating tumour cells (CTCs) – cells that have broken off from the tumour and are circulating in the blood – to investigate a patient’s disease in a minimally invasive manner. 

The researchers, working closely with lung specialist and Medical Oncologist Dr Fiona Blackhall at The Christie NHS Foundation Trust, found that patients with SCLC had many more CTCs in a small sample of their blood than patients with other types of cancer. Importantly, the number of CTCs for each patient was related to their survival – patients with fewer CTCs in their blood lived longer.

Professor Caroline Dive, who led the study, said: “Access to sufficient tumour tissue is a major barrier to us fully understanding the biology of SCLC. This liquid biopsy is straightforward and not invasive so can be easily repeated and will allow us to study the genetics of each lung cancer patient’s individual tumour. It also means that we may have a feasible way of monitoring patient response to therapy, hopefully allowing us to personalise and tailor individual treatment plans to each patient.”

In addition, the team were able to use these CTCs to grow tumour models in mice, which they termed CTC-derived explants (CDXs). When they treated these mice with the same chemotherapy drugs as the SCLC patients they showed that the CDXs responded in the same way as each donor patient.

“We can use these models to help us understand why so many SCLC patients acquire resistance to chemotherapy and to search for and test potential new targeted treatments,” added Professor Dive.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More Than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Molecular Clues to Serious Illnesses to be Explored
The University of Manchester is to lead a new £2.9 million molecular pathology research project to improve diagnosis and treatment of non-cancerous diseases within the NHS.
Friday, July 31, 2015
Molecular Clues to Serious Illnesses to be Explored
The University of Manchester is to lead a new £2.9 million molecular pathology research project to improve diagnosis and treatment of non-cancerous diseases within the NHS.
Tuesday, July 28, 2015
Mould Unlocks New Route to Biofuels
Scientists at The University of Manchester have made an important discovery that forms the basis for the development of new applications in biofuels and the sustainable manufacturing of chemicals.
Monday, July 06, 2015
Gene Variants Show Potential In Predicting Rheumatoid Arthritis Disease Outcomes
Arthritis Research UK-funded scientists at The University of Manchester have identified a new way in which genotyping can be used to predict disease outcomes among sufferers of rheumatoid arthritis.
Thursday, April 30, 2015
Potential For Prediction Of Progression For Early Form Of Breast Cancer
Scientists in Manchester have identified a way to potentially predict which patients with an early form of breast cancer will experience disease progression.
Friday, April 17, 2015
Surprising Finding In Stroke Research
Scientists at The University of Manchester have made an important new discovery about the brain’s immune system that could lead to potential new treatments for stroke and other related conditions.
Wednesday, March 18, 2015
Current Detection of Gene Mutations Misses People At High Risk Of Cancer
Research on the BRCA gene mutation in the Jewish population shows that the current process of identifying people misses half the people who have the mutation and are at risk of developing cancer.
Tuesday, December 02, 2014
New Insight into Drug Resistance in Metastatic Melanoma
A study by scientists in Manchester has shown how melanoma drugs can cause the cancer to progress once a patient has stopped responding to treatment.
Wednesday, June 04, 2014
Health Risks from Arsenic in Rice Exposed
High levels of arsenic in rice have been shown to be associated with elevated genetic damage in humans, a new study has found.
Wednesday, July 24, 2013
Study Maps Human Metabolism in Health and Disease
Scientists have produced an instruction manual for the human genome that provides a framework to better understand the relationship between an individual’s genetic make-up and their lifestyle.
Monday, March 04, 2013
Yeast Unravels Effects of Chemotherapy Drugs
Researchers identify new biological processes involved in the cellular response to N-BPs, opening up opportunities for the development of new anticancer drugs.
Friday, September 11, 2009
New Strategy in Fight against Cancer
Scientists have identified a new strategy in the fight against cancer, having found a mechanism for switching off a chemical signal that is intimately linked to progression of the disease.
Monday, September 22, 2008
Gene may Hold Key to Future Cancer Hope
The University of Manchester research has identified a key gene that appears to play a critical role in the normal process of cell division.
Tuesday, October 09, 2007
Eden Biodesign and the University of Manchester Intellectual Property Limited Develop Innovative Treatment for Cancer
UMIP selects Eden Biodesign to provide a range of services for the development of therapeutic for treatment of macular degeneration and cancer.
Wednesday, August 08, 2007
£2million Dwarfism Study Launched
An international team of researchers have been awarded more than £2million to study the genetic causes of dwarfism in a bid to develop future treatments.
Friday, June 01, 2007
Scientific News
Liquid Biopsies: Utilization of Circulating Biomarkers for Minimally Invasive Diagnostics Development
Market Trends in Biofluid-based Liquid Biopsies: Deploying Circulating Biomarkers in the Clinic. Enal Razvi, Ph.D., Managing Director, Select Biosciences, Inc.
Lab-on-a-Chip Offers Promise for TB and Asthma Patients
A device to mix liquids using ultrasonics is the first and most difficult component in a miniaturized system for low-cost analysis of sputum from patients with pulmonary diseases such as tuberculosis and asthma.
Intracellular Microlasers Could Allow Precise Labeling of up to a Trillion Individual Cells
MGH investigators have induced structures incorporated within individual cells to produce laser light at wavelengths that differ based on the size, shape and composition of each microlaser, allowing precise labeling of individual cells.
Real-Time Imaging of Lung Lesions During Surgery
Targeted molecular agents cause lung adenocarcinomas to fluoresce during surgery, according to pilot report.
Watching a Tumour Grow in Real-Time
Researchers from the University of Freiburg have gained new insight into the phases of breast cancer growth.
Protein Related to Long Term Traumatic Brain Injury Complications Discovered
NIH-study shows protein found at higher levels in military members who have suffered multiple TBIs.
Childhood Cancer Cells Drain Immune System’s Batteries
Cancer cells in neuroblastoma contain a molecule that breaks down a key energy source for the body’s immune cells, leaving them too physically drained to fight the disease.
Urine Proteins Point to Early-Stage Pancreatic Cancer
A combination of three proteins found at high levels in urine can accurately detect early-stage pancreatic cancer, researchers at the BCI have shown.
Researcher Discovers Trigger of Deadly Melanoma
New research sheds light on the precise trigger that causes melanoma cancer cells to transform from non-invasive cells to invasive killer agents, pinpointing the precise place in the process where "traveling" cancer turns lethal.
New Vaccine For Chlamydia to Use Synthetic Biology
Prokarium Ltd, a biotechnology company developing transformational oral vaccines, have announced new funding from SynbiCITE, the UK’s Innovation and Knowledge Centre for Synthetic Biology.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!