Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Hot Spots for Molecules

Published: Thursday, June 12, 2014
Last Updated: Thursday, June 12, 2014
Bookmark and Share
The accurate placement of molecules into gaps between gold nanoantennas enables ultra-high sensitivity molecular detection.

The ability to detect tiny quantities of molecules is important for chemical sensing as well as biological and medical diagnostics. In particular, some of the most challenging and advanced applications involve rare compounds for which only a few molecules may be present at a time.

The most promising devices for achieving ultrahigh-precision detection are nanoscale sensors, where molecules are placed in tiny gaps between small gold plates. But this method is effective only if the molecules are positioned accurately within the gaps.

Now, Jinghua Teng from the A*STAR Institute of Materials Research and Engineering, Singapore, and colleagues from the National University of Singapore, have developed a sensor where molecules are efficiently guided and placed into position.

The electronic resonances occurring in gold nanostructures are like very powerful antennas, able to amplify radiation from small molecules in their vicinity. This permits even the detection of single molecules. In order for the signal to be picked up by the antennas, however, the molecules need to be precisely located within electromagnetic ‘hot spots’.

“We approached this challenge and developed a method to selectively bind the molecules to the electromagnetic hot spots in the nanoantenna structure for maximum effect,” explains Teng.

The researchers needed to prepare the device surface such that the molecules bind only to the desired areas between the gold plates - not on them. They achieved this by depositing a thin titanium film between the gold plates. The titanium oxidizes in air, forming stable titanium dioxide, which is insulating and has very different properties to the gold plates.

The researchers then covered the surface with various organic solutions that selectively prevent proteins and other molecules from binding to the gold while attracting the molecules of interest to the titanium pad. In initial tests, signals from molecules attached to the titanium in the hot spot showed a six times higher sensitivity than those randomly attached across the device.

The next step will be to increase the sensor sensitivity to the ultimate limit, explains Teng. “People have been dreaming of and working toward single-molecule sensing. This work is part of these efforts. It provides a way to selectively bind biomolecules to the hot spots and proves that it can enhance the molecular sensitivity and reduce the amount of sample required.”

Further improvements in device design will however be required, adds Teng. “Moving forward, we would like to further push the sensitivity by optimizing the structure and try multi-agent sensing in one chip.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More Than 4,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Open Source Seed Initiative – A Welcome Boost to Global Crop Breeding
A team of plant breeders, farmers, non-profit agencies, seed advocates, and policymakers have created the Open Source Seed Initiative.
ASMS 2016: Targeting Mass Spectrometry Tools for the Masses
The expanding application range of MS in life sciences, food, energy, and health sciences research was highlighted at this year's ASMS meeting in San Antonio, Texas.
Benchtop Automation Trends
Gain a better understanding of current interest in and future deployment of benchtop automated systems.
Anthrax Proteins Might Help Treat Cancerous Tumors
Studies in mice reveal novel treatment regimen.
New Cancer Drug Target Found in Dual-Function Protein
Findings from a study from TSRI have shown that targeting a protein called GlyRS might help to halt cancer growth.
Key to Chronic Fatigue Syndrome is in Your Gut, Not Head
Researchers report they have identified biological markers of the disease in gut bacteria and inflammatory microbial agents in the blood.
HIV Structure Stabilized
Findings represent ‘big accomplishment’ in biomedical engineering and design.
Four Newly-Identified Genes Could Improve Rice
A Japanese research team have applied a method used in human genetic analysis to rice and rapidly discovered four new genes that are potentially significant for agriculture. These findings could influence crop breeding and help combat food shortages caused by a growing population.
New Cancer Drug Target in Dual-Function Protein
Scientists at The Scripps Research Institute (TSRI) have identified a protein that launches cancer growth and appears to contribute to higher mortality in breast cancer patients.
Antibodies To Dengue May Alter Course Of Zika Virus Infection
Scientists at Emory Vaccine Center, in collaboration with investigators from Thailand, have found that people infected with dengue virus develop antibodies that cross-react with Zika virus.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!