Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Sunscreen Is Not Enough to Prevent Skin Cancer

Published: Friday, June 13, 2014
Last Updated: Friday, June 13, 2014
Bookmark and Share
Scientists have shown that sunscreen cannot be relied upon alone to prevent malignant melanoma, according to research published in Nature.

The work supports the approach taken by public health campaigns that call for people to use a combination of shade and clothing to protect their skin, applying sunscreen to the areas you can’t cover.

The research explains more about the mechanism by which UV light leads to melanoma and also explores the extent to which sunscreen is able to prevent UV light from damaging healthy cells.

In the study, carried out at Cancer Research UK’s Manchester Institute, based at The University of Manchester, and at The Institute of Cancer Research, London, scientists examined the molecular effects of UV light on the skin of mice at risk of melanoma** and whether disease development was blocked by sunscreen.

UV light directly damages the DNA in the skin’s pigment cells, increasing the chances of developing melanoma. Crucially, the researchers show that it causes faults in the p53 gene, which normally helps protect from the effects of DNA damage caused by UV light.

The study also showed that sunscreen can greatly reduce the amount of DNA damage caused by UV, delaying the development of melanoma in the mice. But, importantly, the study also found that sunscreen did not offer complete protection and UV light could still target p53 to induce melanoma, albeit at a reduced rate.

Professor Richard Marais, study author and Cancer Research UK scientist, based at the University of Manchester, said: “UV light has long been known to cause melanoma skin cancer, but exactly how this happens has not been clear. These studies allow us to begin to understand how UV light causes melanoma.

“UV light targets the very genes protecting us from its own damaging effects, showing how dangerous this cancer-causing agent is. Very importantly, this study provides proof that sunscreen does not offer complete protection from the damaging effects of UV light.

“This work highlights the importance of combining sunscreen with other strategies to protect our skin, including wearing hats and loose fitting clothing, and seeking shade when the sun is at its strongest.”

Dr Julie Sharp, head of health information at Cancer Research UK, said: “We’ve known for some time that sunscreen, when applied properly, can help protect our skin from the harmful effects of the sun’s rays. But people tend to think they’re invincible once they’ve put it on and end up spending longer out in the sun, increasing their overall exposure to UV rays.

“This research adds important evidence showing that sunscreen has a role, but that you shouldn’t just rely on this to protect your skin. It’s essential to get into good sun safety habits, whether at home or abroad, and take care not to burn – sunburn is a clear sign that the DNA in your skin cells has been damaged and, over time, this can lead to skin cancer.

“When the sun is strong, pop on a t-shirt, spend some time in the shade and use a sunscreen with at least SPF15 and good UVA protection.”

Professor Nic Jones, Cancer Research UK’s chief scientist and director of the Manchester Cancer Research Centre, said: “Malignant melanoma is now the fifth most common cancer in the UK, with more than 13,000 people being diagnosed with the disease every year. With the number of cases increasing, we urgently need to understand more about the disease and find new and better treatments. And this is why we’re making skin cancer research one of the key focuses of the Manchester Cancer Research Centre.”

The paper entitled "Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53." is published in Nature and can be accessed online. 



Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More Than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Point of Care Diagnostics - A Cautious Revolution
Advances in molecular biology, coupled with the miniaturization and improved sensitivity of assays and devices in general, have enabled a new wave of point-of-care (POC) or “bedside” diagnostics.
Mass Spec Technology Drives Innovation Across the Biopharma Workflow
With greater resolving power, analytical speed, and accuracy, new mass spectrometry technology and techniques are infiltrating the biopharmaceuticals workflow.
One Step Closer to Precision Medicine for Chronic Lung Disease Sufferers
A study led by University of North Carolina at Chapel Hill, and National Jewish Health, has provided evidence of links between SNPs and known COPD blood protein biomarkers.
Modified Yeast Shows Plant Response to Key Hormone
Researchers have developed a toolkit based on modified yeast to determine plant responses to auxin.
Adipose Tissue Secretes Factors That Activate Metabolism
Study finds brown adipose tissue secretes signalling factors that activates metabolism of fat and carbohydrates.
Antibiotic Resistant Bacteria In America's Water System
Antibiotic resistant bacteria live inside drinking water distribution systems blamed for rising healthcare costs.
ReadCoor Launched to Commercialize 3D Sequencing Tech
ReadCoor will leverage the Wyss Institute’s method for simultaneously sequencing and mapping RNAs within cells and tissues to advance development of diagnostics.
Ancient Eggshell Protein Breaks Through DNA Time Barrier
Fossil proteins from a 3.8million year-old eggshell have been identifed, suggests proteins could give insight into evolutionary tree.
Monkeys Protected by Zika DNA Vaccine
Experimental Zika virus DNA vaccines successfully protected monkeys against Zika infection.
Nanosensors Could Determine Tumours’ Ability to Remodel Tissue
Researchers design nanosensors that can profile tumours, focusing on protease levels.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!