Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New High Resolution Accurate Mass LC-MS System Scans 50 Percent Faster than Predecessor

Published: Monday, June 16, 2014
Last Updated: Monday, June 16, 2014
Bookmark and Share
When it comes to pursuing breakthroughs in proteomics research, there’s no such thing as too much scanning speed, as long as data quality remains high. The latest addition to the industry-leading Q Exactive family of Thermo Scientific liquid chromatography-mass spectrometry (LC-MS) systems addresses this demand.

The Thermo Scientific Q Exactive HF system is making its debut at the 62nd ASMS Conference on Mass Spectrometry and Allied Topics, booth 127, and at the Holiday suite in the Hilton Baltimore Hotel. 

To create the new Q Exactive HF system, Thermo Fisher Scientific added an ultra-high-field Orbitrap mass analyzer to the proven Q Exactive Plus LC-MS platform. Designed for faster identification, characterization, quantification, and confirmation in a single, high-confidence analysis; maximum scanning rates increase from 12 Hz to 18 Hz to significantly improve productivity. Internal research indicates that the Q Exactive HF can provide complete MS/MS identification for 18 scans in one second, compared to half that number using the previous Q Exactive systems for the same duration gradient, without compromising data quality. Maximum resolution is 240,000 at m/z 200. 

“The peptide sequencing speed of the new Q Exactive HF system is amazing,” said Professor Jesper V. Olsen of the Novo Nordisk Foundation Center for Protein Research, an early-access user. “For shotgun analysis of human proteomes, we can now obtain the same data in half the time. We can therefore analyze many more cell conditions than before.” 

Advanced quadrupole technology optimizes precursor selection and transmission for excellent detection of low-abundance ions in very complex matrices. Advanced active ion beam guide design enhances sensitivity and robustness. Quantitation capabilities include: selected ion monitoring, parallel reaction monitoring and data-independent acquisition. An optional intact protein mode enhances analysis of intact proteins. 

“For data-independent acquisition, we need to balance precursor selectivity, duty cycle, and the target mass range of interest,” said Professor Michael MacCoss of the University of Washington School of Medicine, another early access user. “The Q Exactive HF instrument enables us to substantially improve the precursor selectivity without affecting the other parameters of the experiment. Ultimately, this improves the sensitivity and quantitative dynamic range in a complex mixture.” 

“Orbitrap technology is evolving to become faster, better performing and more accessible,” said Iain Mylchreest, vice president research and develpoment, chromatography and mass spectrometry, Thermo Fisher Scientific. “We’re pleased to make the performance of the newest Orbitrap analyzer available to Q Exactive HF customers.” 


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More Than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Thermo Launches Geneticon
Thermo Fisher Scientific launches GenetiCon, a virtual resource showcasing the real-life science behind superheroic powers and more.
Tuesday, July 07, 2015
Thermo Fisher Agrees to Buy Alfa Aesar for $403M
The company announced a definitive agreement to buy the research chemical manufacturer for $403 million.
Friday, June 26, 2015
Ebola Sequencing Data Released to Global Research Community Online
To curb further spread of Ebola in Sierra Leone, a team of scientists that is part of an international, multi-organizational effort has released their first dataset of the virus’ genetic structure online.
Wednesday, June 03, 2015
Thermo's NGS Platform Selected for Nationwide Clinical Research Program
National Cancer Institute-MATCH trial to sequence thousands of tumor samples using Ion Torrent targeted sequencing technology.
Monday, June 01, 2015
Thermo Strengthens Bioprocessing Offering with Advanced Scientifics Acquisition
Thermo Fisher Scientific has acquired Advanced Scientifics, Inc., a global provider of single-use technologies for customized bioprocessing solutions, for $300 million in cash.
Friday, February 06, 2015
Thermo Fisher Q3 Revenues up 31 Percent
Thermo Fisher announced that revenues grew 31% to $4.17 billion for the third quarter ended September 27, 2014.
Thursday, October 23, 2014
Thermo Scientific Announces Listing of the Ion PGM Dx System
Company has completed the listing with the U.S. FDA as class II medical device.
Saturday, September 20, 2014
Thermo Fisher, NRLs Team to Confirm Dioxins in Feed and Food
Thermo Fisher Scientific worked closely with national reference labs (NRLs) in the European Union to support the development of new regulation.
Monday, September 08, 2014
Thermo Completes Sale of Cole-Parmer to GTCR
Thermo Fisher Scientific Inc. announced that it has completed the sale of its Cole-Parmer customer channel business to private equity firm GTCR LLC for approximately $480 million in cash.
Wednesday, August 20, 2014
Thermo Supports Distinguished Analytical Chemistry Seminar Series at NC State
An endowment established by the company provides opportunities to attend presentations by leading analytical chemistry authorities.
Tuesday, August 19, 2014
NSF International Expands Use of Thermo Scientific Watson LIMS
NSF International implements Thermo Scientific Watson LIMS to support bioanalytical testing for both clinical and non-clinical research studies at Bristol, CT laboratory.
Saturday, August 09, 2014
Thermo, NewLab Sign Forensic Sample Processing Distribution Agreement
Under the agreement, Thermo Fisher is the sole distributor and servicing agent of the CPA300™ and CPA200™ card processing instruments.
Friday, July 25, 2014
Thermo to Sell Cole-Parmer for $480M
Company has signed a definitive agreement to sell its Cole-Parmer channel business to private equity firm GTCR, LLC for $480 million in cash.
Monday, July 21, 2014
Reimagining UHPLC
To learn more about the new Vanquish UHPLC system from Thermo Fisher Scientific we spoke to Wulff Niedner, Director of HPLC Product Marketing.
Thursday, July 17, 2014
ATCC, CDC and Thermo Partner on Public Health RT-PCR Assay
New technology supports HIV-1 drug resistance surveillance in resource-limited countries.
Wednesday, June 25, 2014
Scientific News
Study Finds Brain Chemicals that Keep Wakefulness in Check
Researchers to develop new drugs that promote better sleep, or control hyperactivity in people with mania.
Sorting Through Cellular Statistics
Aaron Dinner, professor in chemistry, and his graduate student Herman Gudjonson are trying to read the manual of life, DNA, as part of the Dinner group’s research into bioinformatics—the application of statistics to biological research.
Playing 'Tag' with Pollution lets Scientists See Who's It
Using a climate model that can tag sources of soot from different global regions and can track where it lands on the Tibetan Plateau, researchers have determined which areas around the plateau contribute the most soot — and where.
Women’s Immune System Genes Operate Differently from Men’s
A new technology reveals that immune system genes switch on and off differently in women and men, and the source of that variation is not primarily in the DNA.
Long Telomeres Associated with Increased Lung Cancer Risk
Genetic predisposition for long telomeres predicts increased lung adenocarcinoma risk.
First Artificial Ribosome Designed
Researchers at the University of Illinois at Chicago and Northwestern University have engineered a tethered ribosome that works nearly as well as the authentic cellular component, or organelle, that produces all the proteins and enzymes within the cell.
High-Resolution 3D Images Reveal the Muscle Mitochondrial Power Grid
NIH mouse study overturns scientific ideas on energy distribution in muscle.
Expanding the Brain
A team of researchers has identified more than 40 new “imprinted” genes, in which either the maternal or paternal copy of a gene is expressed while the other is silenced.
Identifying a Key Growth Factor in Cell Proliferation
Researchers discover that aspartate is a limiter of cell proliferation.
Study Uncovers Target for Preventing Huntington’s Disease
Scientists from Cardiff University believe that a treatment to prevent or delay the symptoms of Huntington’s disease could now be much closer, following a major breakthrough.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!