Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Genetic Pathway for Chronic Kidney Disease Revealed

Published: Monday, June 23, 2014
Last Updated: Monday, June 23, 2014
Bookmark and Share
Findings from the study open the door to early treatment for millions at risk for CKD.

The University of Michigan Medical School led an international group of researchers in creating a molecular map of the body changes leading to chronic kidney disease.

Partly due to an aging and overweight population, chronic kidney disease  — a condition in which damaged kidneys cannot filter blood as well as healthy kidneys  — is one of the nation’s fastest growing chronic diseases.

“Addressing the initial mechanisms of CKD may be more beneficial and is good news for patients who could receive therapy earlier on for a variety of kidney diseases before they progress into CKD,” says Matthias Kretzler, M.D., a professor of internal medicine and bioinformatics and a nephrologist at the U-M Health System.

Diseases and infections that can damage kidneys and cause CKD include autoimmune disease like lupus leading to glomerulonephritis, polycystic kidney disease or kidney problems people are born with.

However, the most common causes of chronic kidney disease are diabetes and high blood pressure.  CKD affects over 13 percent of the United States population, about 26 million people.

Using combined genetic and clinical data, Kretzler, U-M’s Sebastian Martini, M.D., and colleagues revealed a network of shared genetic pathways associated with CKD. 

This unique methodology helped to describe what the key molecular drivers of CKD are, what CKD-causing diseases were most closely related and to understand specific molecular mechanisms causing the disease to progress or worsen in different patients.

The CKDGen consortium, European Renal cDNA Bank-Kroener-Fresenius Biopsy Bank, and the Clinical Phenotyping Resource and Biobank core contributed to the study published online ahead of print in the Journal of the American Society of Nephrology.

"The study highlighted why understanding the way different diseases share the same molecular mechanism is important for treatment," says Martini, a systems biologist at the U-M Medical School.

Current treatments can decrease the rate at which CKD worsens and contributes to other health problems, but they do not prevent progression.  Once kidneys fail, people need dialysis or a kidney transplant to live.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More Than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Breaking the Brain’s Garbage Disposal
The children’s ataxia gene problem turned out to be not such a big deal genetically — it was such a slight mutation that it barely changed the way the cells made the protein.
Wednesday, January 27, 2016
Silencing X Chromosomes
Work could lead to ways to counteract X-linked diseases in girls and women.
Tuesday, January 12, 2016
Precision Medicine for Penile Cancer
Defining the genomic landscape reveals similarities with other squamous cell cancers.
Thursday, December 17, 2015
New Method to Purify Water
The method sounds like a salad dressing recipe: take water, sprinkle in nanomaterials, add oil and shake.
Monday, December 14, 2015
X Chromosome Discovery Could Aid Research on Many Sex-Linked Disorders
U-M researchers find new way for RNA to regulate genetic activity.
Thursday, October 22, 2015
A New Factor in Depression?
Study in humans & rats shows more physical changes in depressed brains.
Thursday, September 10, 2015
Adrenals Run Amok
Each of your kidneys wears a little yellow cap that helps keep your blood pressure in check, and much more. But in some people, it starts running amok, pumping out a hormone that sends blood pressure sky-high.
Friday, August 14, 2015
What Drives Advanced Prostate Cancer?
Large international study finds 90% have anomaly that could influence treatment.
Tuesday, May 26, 2015
New Device May Shed Light on Why Cancer Cells Metastasize
Scientists from the University of Michigan think they are now a step closer to understanding why some cancer cells metastasize.
Thursday, May 21, 2015
Tailor-Made Cancer Treatments? New Cell Culture Technique Paves The Way
Technique grew cells from 73% of patients in the study, more than three times as effective as previous methods.
Friday, December 19, 2014
Thyroid Cancer Genome Analysis Finds Markers Of Aggressive Tumors
TCGA study reveals molecular underpinnings; could lead to more precisely targeted treatment recommendations.
Monday, October 27, 2014
Dietary Recommendations May Harm Environment
If Americans adopted the USDA's "Dietary Guidelines for Americans, 2010," recommendations while keeping caloric intake constant, diet-related greenhouse gas emissions would increase 12 percent.
Monday, September 08, 2014
When Drugs Do More Harm Than Good for Type 2 Diabetes Patients
Harm to quality of life outweighs benefits of treatment for older patients and those with negative feelings about side effects.
Wednesday, July 02, 2014
How a Silly Putty Ingredient Could Advance Stem Cell Therapies
The sponginess of the environment where human embryonic stem cells are growing affects the type of specialized cells they eventually become.
Thursday, April 17, 2014
Scientists Slow Development of Alzheimer's Cell-Killing Plaques
Researchers have learned how to fix a cellular structure called the Golgi that becomes fragmented in Alzheimer's patients.
Tuesday, March 18, 2014
Scientific News
Criminal Justice Alcohol Program Linked to Decreased Mortality
Institute has announced that in the criminal justice alcohol program deaths dropped by 4.2 percent over six years.
Charting Kidney Cancer Metabolism
Changes in cell metabolism are increasingly recognized as an important way tumors develop and progress, yet these changes are hard to measure and interpret. A new tool designed by MSK scientists allows users to identify metabolic changes in kidney cancer tumors that may one day be targets for therapy.
Improving Regenerative Medicine
Lab-created stem cells may lack key characteristics, UCLA research finds.
Tick Genome Reveals Secrets of a Successful Bloodsucker
NIH has announced that decipher the genome of the blacklegged tick which could lead to new tick control methods.
"Dark Side" of the Transcriptome
New approach to quantifying gene "read-outs" reveals important variations in protein synthesis and has implications for understanding neurodegenerative diseases.
Individuals' Medical Histories Predicted by their Noncoding Genomes
Researchers have found that analyzing mutations in regions of the genome that control genes can predict medical conditions such as hypertension, narcolepsy and heart problems.
'Molecular Movie' Opens Door to New Cancer Treatments
An international team of scientists led by the University of Liverpool has produced a 'structural movie' revealing the step-by-step creation of an important naturally occurring chemical in the body that plays a role in some cancers.
New Source of Mutations in Cancer
Recently, a new mutation signature found in cancer cells was suspected to have been created by a family of enzymes found in human cells called the APOBEC3 family.
Advancing Synthetic Biology
Living systems rely on a dizzying variety of chemical reactions essential to development and survival. Most of these involve a specialized class of protein molecules — the enzymes.
Madison Researchers Begin Work on Zika Virus
Work will start with basic questions about Zika virus infection.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!