Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Genetic Pathway for Chronic Kidney Disease Revealed

Published: Monday, June 23, 2014
Last Updated: Monday, June 23, 2014
Bookmark and Share
Findings from the study open the door to early treatment for millions at risk for CKD.

The University of Michigan Medical School led an international group of researchers in creating a molecular map of the body changes leading to chronic kidney disease.

Partly due to an aging and overweight population, chronic kidney disease  — a condition in which damaged kidneys cannot filter blood as well as healthy kidneys  — is one of the nation’s fastest growing chronic diseases.

“Addressing the initial mechanisms of CKD may be more beneficial and is good news for patients who could receive therapy earlier on for a variety of kidney diseases before they progress into CKD,” says Matthias Kretzler, M.D., a professor of internal medicine and bioinformatics and a nephrologist at the U-M Health System.

Diseases and infections that can damage kidneys and cause CKD include autoimmune disease like lupus leading to glomerulonephritis, polycystic kidney disease or kidney problems people are born with.

However, the most common causes of chronic kidney disease are diabetes and high blood pressure.  CKD affects over 13 percent of the United States population, about 26 million people.

Using combined genetic and clinical data, Kretzler, U-M’s Sebastian Martini, M.D., and colleagues revealed a network of shared genetic pathways associated with CKD. 

This unique methodology helped to describe what the key molecular drivers of CKD are, what CKD-causing diseases were most closely related and to understand specific molecular mechanisms causing the disease to progress or worsen in different patients.

The CKDGen consortium, European Renal cDNA Bank-Kroener-Fresenius Biopsy Bank, and the Clinical Phenotyping Resource and Biobank core contributed to the study published online ahead of print in the Journal of the American Society of Nephrology.

"The study highlighted why understanding the way different diseases share the same molecular mechanism is important for treatment," says Martini, a systems biologist at the U-M Medical School.

Current treatments can decrease the rate at which CKD worsens and contributes to other health problems, but they do not prevent progression.  Once kidneys fail, people need dialysis or a kidney transplant to live.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More Than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

'Kidney on a Chip' Facilitates Safer Drug Dosing
University of Michigan researchers have used a "kidney on a chip" device to mimic the flow of medication through human kidneys and measure its effect on kidney cells.
Friday, May 06, 2016
Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Friday, April 29, 2016
Ancient Viruses Lurk in Our DNA
One whole endogenous retrovirus genome -- and bits of 17 others -- were spotted in a study of 2,500 human genomes.
Thursday, March 24, 2016
Making Stem Cells 'Embryonic' Again
Research in mice shows for the first time that erasing epigenetic markers on chromatin can return stem cells to original state.
Monday, March 21, 2016
Lead Exposure Changes Gut Microbiota
Exposure to lead during early development can alter the the gut microbiota, increasing the chances for obesity in adulthood, researchers from the University of Michigan School of Public Health have found.
Monday, March 14, 2016
Breaking the Brain’s Garbage Disposal
The children’s ataxia gene problem turned out to be not such a big deal genetically — it was such a slight mutation that it barely changed the way the cells made the protein.
Wednesday, January 27, 2016
Silencing X Chromosomes
Work could lead to ways to counteract X-linked diseases in girls and women.
Tuesday, January 12, 2016
Precision Medicine for Penile Cancer
Defining the genomic landscape reveals similarities with other squamous cell cancers.
Thursday, December 17, 2015
New Method to Purify Water
The method sounds like a salad dressing recipe: take water, sprinkle in nanomaterials, add oil and shake.
Monday, December 14, 2015
X Chromosome Discovery Could Aid Research on Many Sex-Linked Disorders
U-M researchers find new way for RNA to regulate genetic activity.
Thursday, October 22, 2015
A New Factor in Depression?
Study in humans & rats shows more physical changes in depressed brains.
Thursday, September 10, 2015
Adrenals Run Amok
Each of your kidneys wears a little yellow cap that helps keep your blood pressure in check, and much more. But in some people, it starts running amok, pumping out a hormone that sends blood pressure sky-high.
Friday, August 14, 2015
What Drives Advanced Prostate Cancer?
Large international study finds 90% have anomaly that could influence treatment.
Tuesday, May 26, 2015
New Device May Shed Light on Why Cancer Cells Metastasize
Scientists from the University of Michigan think they are now a step closer to understanding why some cancer cells metastasize.
Thursday, May 21, 2015
Tailor-Made Cancer Treatments? New Cell Culture Technique Paves The Way
Technique grew cells from 73% of patients in the study, more than three times as effective as previous methods.
Friday, December 19, 2014
Scientific News
The Rise of 3D Cell Culture and in vitro Model Systems for Drug Discovery and Toxicology
An overview of the current technology and the challenges and benefits over 2D cell culture models plus some of the latest advances relating to human health research.
Scientists Find Evidence That Cancer Can Arise Changes
Researchers at Rockefeller University have found a mutation that affects the proteins that package DNA without changing the DNA itself can cause a rare form of cancer.
Developing a More Precise Seasonal Flu Vaccine
During the 2014-15 flu season, the poor match between the virus used to make the world’s vaccine stocks and the circulating seasonal virus yielded a vaccine that was less than 20 percent effective.
A Peachy Defense System for Seeds
ETH chemists are developing a new coating method to protect seeds from being eaten by insects. In doing so, they have drawn inspiration from the humble peach and a few of its peers.
Fighting Cancer with Borrowed Immunity
A new step in cancer immunotherapy: researchers from the Netherlands Cancer Institute and University of Oslo/Oslo University Hospital show that even if one's own immune cells cannot recognize and fight their tumors, someone else's immune cells might.
Modified Microalgae Converts Sunlight into Valuable Medicine
A special type of microalgae can soon produce valuable chemicals such as cancer treatment drugs and much more just by harnessing energy from the sun.
Breakthrough Approach to Breast Cancer Treatment
Scripps scientists have designed a drug candidate that decreases growth of breast cancer cells.
Loss Of Y Chromosome Increases Risk Of Alzheimer’s
Men with blood cells that do not carry the Y chromosome are at greater risk of being diagnosed with Alzheimer’s disease. This is in addition to an increased risk of death from other causes, including many cancers. These new findings by researchers at Uppsala University could lead to a simple test to identify those at risk of developing Alzheimer’s disease.
Making Virus Sensors Cheap and Simple
Researchers at The University of Texas at Austin demonstrated the ability to detect single viruses in a solution containing murine cytomegalovirus (MCMV).
A Guide to CRISPR Gene Activation
A comparison of synthetic gene-activating Cas9 proteins can help guide research and development of therapeutic approaches.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!