Corporate Banner
Satellite Banner
Scientific Communities
Become a Member | Sign in
Home>News>This Article

Researchers Identify Urgent Need for Alzheimer's Disease Drug Development

Published: Friday, July 04, 2014
Last Updated: Friday, July 04, 2014
Bookmark and Share
Analysis of clinical trials published in the journal Alzheimer's Research & Therapy shows that the pipeline for potential treatments of AD is small and rate of success is limited.

Researchers at the Cleveland Clinic Lou Ruvo Center for Brain Health have examined - the largest clinical trials database - for all ongoing studies for Alzheimer's disease (AD) from the years 2002 to 2012. They found an urgent need to increase the number of agents entering the AD drug development pipeline and progressing successfully towards new therapy treatments. 

The main findings of the study conclude that there are relatively few drugs in development for Alzheimer's disease; the failure rate for AD drug development is 99.6% for the decade 2002-2012; and the number of drugs has been declining since 2009. 

Jeffrey Cummings, lead researcher from Cleveland Clinic Lou Ruvo Center for Brain Health, says: "Our goal was to examine historical trends to help understand why Alzheimer's disease treatment development efforts so often fail. With an estimated 44 million people living with the condition, the study shows that the Alzheimer's disease drug development ecosystem needs more support given the magnitude of the problem." 

This comprehensive analysis illustrates the high rate of failure of compounds and the need for a constant supply of new drugs or a higher focus on repurposing studies is needed. Repurposing studies involve taking an existing approved drug and studying it in a new use or condition to see if current treatments could be used in new ways. With AD more expensive to the US economy than cardiovascular disease or cancer, researchers believe the system of AD drugs must be supported, grown and coordinated to improve the success rate and development of new AD therapies. 

Kate Zhong, another researcher on the study, says: "By analyzing both completed as well as on-going trials and currently active compounds, we were able to provide insight into longitudinal trends in drug development. What we found was that the investment in AD drugs and therapies is relatively low compared to the challenge posed by the disease. The pipeline is almost dry."

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More Than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Imaging Software Could Speed Up Breast Cancer Diagnosis
Researchers use high speed optical microscopy of intact breast tissue specimens to analyze breast tissue.
Friday, August 21, 2015
Detecting and Identifying Candida Species in Blood Samples of Critically Ill Paediatric Patients
The study aimed to develop a multiplex nested PCR method to detect and identify seven Candida species in peripheral blood samples of critically ill paediatric patients.
Wednesday, August 27, 2014
Showing Your Age: Your DNA Doesn't Lie
Using thousands of tissue samples from open access datasets, a scientist has created a calculator which predicts the age of tissue using chemical changes to DNA.
Monday, October 21, 2013
Leukaemia Drug Could Help Treat Breast Cancer
A drug currently used to treat leukaemia might also help prevent breast cancer from spreading to other parts of the body.
Friday, August 23, 2013
No Place to Hide: Evolutionary Forensics
The rapid molecular evolution of hepatitis C virus (HCV) has been used to help incriminate the source of an outbreak in two Spanish hospitals in the late nineties.
Monday, July 29, 2013
A Possible Blood Test for Alzheimer’s Disease
A new blood test can be used to discriminate between people with Alzheimer's disease and healthy controls.
Monday, July 29, 2013
Is Enough Being Done to Make Drinking Water Safe?
Arsenic in water is threatening the lives of several hundred million people.
Monday, June 03, 2013
Women’s Immune Systems Remain Younger for Longer
The slower decline in a woman’s immune system may contribute to women living longer than men.
Wednesday, May 15, 2013
Testing the Water – Urine Test Identifies Babies at Most Risk of Necrotizing Enterocolitis
Abnormal gut bacteria in premature babies can be found days before the onset of necrotizing enterocolitis (NEC) finds new research in BioMed Central’s open access journal Microbiome.
Tuesday, April 16, 2013
Gene Signature Can Predict Who Will Survive Chemotherapy
An eight gene ‘signature’ can predict length of relapse-free survival after chemotherapy, finds new research in Biomed Central’s open access journal BMC Medicine.
Tuesday, April 16, 2013
The Tulip Tree Reveals Mitochondrial Genome of Ancestral Flowering Plant
The extraordinary level of conservation of the tulip tree mitochondrial genome has redefined our interpretation of evolution of the angiosperms (flowering plants).
Tuesday, April 16, 2013
Organizing Human Specimen Collections: Getting the Best out of Biobanks
The diversity of biobanks, collections of human specimens from a variety of sources, raises questions about the best way to manage and govern them.
Friday, March 22, 2013
Oxygen-Free Energy Designed to Fuel Brain Development Spurs on Growth of Cancer
The metabolic process which fuels the growth of many cancers has its origins in normal brain growth finds a new study published in BioMed Central's open access journal Cancer & Metabolism.
Wednesday, January 23, 2013
What Did Our Ancestors Look Like?
A new method of establishing hair and eye colour from modern forensic samples can also be used to identify details from ancient human remains.
Monday, January 14, 2013
Microevolutionary Analysis of C. difficile Genomes to Investigate Transmission
Recent study took a genomics approach to assess the incidence of patient-to-patient transmission of C. difficile.
Thursday, January 03, 2013
Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
How a Genetic Locus Protects Adult Blood-Forming Stem Cells
Mammalian imprinted Gtl2 protects adult hematopoietic stem cells by restricting metabolic activity in the cells' mitochondria.
Genetic Basis of Fatal Flu Side Effect Discovered
A group of people with fatal H1N1 flu died after their viral infections triggered a deadly hyperinflammatory disorder in susceptible individuals with gene mutations linked to the overactive immune response, according to a recent study.
New Tech Vastly Improves CRISPR/Cas9 Accuracy
A new CRISPR/Cas9 technology developed by scientists at UMass Medical School is precise enough to surgically edit DNA at nearly any genomic location, while avoiding potentially harmful off-target changes typically seen in standard CRISPR gene editing techniques.
The MaxSignal Colistin ELISA Test Kit from Bioo Scientific
Kit can help prevent the antibiotic apocalypse by keeping last resort drugs out of the food supply.
"Good" Mozzie Virus Might Hold Key to Fighting Human Disease
Australian scientists have discovered a new virus carried by one of the country’s most common pest mosquitoes.
Non-Disease Proteins Kill Brain Cells
Scientists at the forefront of cutting-edge research into neurodegenerative diseases such as Alzheimer’s and Parkinson’s have shown that the mere presence of protein aggregates may be as important as their form and identity in inducing cell death in brain tissue.
Closing the Loop on an HIV Escape Mechanism
Research team finds that protein motions regulate virus infectivity.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Potential Treatment for Life-Threatening Viral Infections Revealed
The findings point to new therapies for Dengue, West Nile and Ebola.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos