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Stainless Steel Vial Filling System Developed for use in Vaccine Facilities

Published: Thursday, July 17, 2014
Last Updated: Thursday, July 17, 2014
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Provides enhanced operator safety and effective decontamination capabilities.

TAP Biosystems has announced the development of a stainless steel version of the fill-it™ system, designed for safely dispensing biohazardous materials such as vaccine stocks.

The stainless steel version of fill-it was developed in response to a request from a major pharmaceutical company and is ideally-suited to the demands of working with highly potent vaccine stock. It fits into standard isolator cabinets, thus reducing the product contamination risk, as well as the operator’s exposure to this biohazardous material.

The system automatically decaps, accurately fills and recaps a rack of 24 off, 2ml vaccine vials every two minutes. This ensures vial-to-vial consistency and because there is no need for any manual intervention, makes routine vial fill and finishing much safer.

Each vaccine batch is aseptically processed on fill-it using GMP-certified, single-use tubing that is destroyed after use. The fill-it’s stainless steel exterior can be sterilized after each batch run with high strength hydrogen peroxide vapour, further reducing product contamination risk.

Stephen Guy, fill-it Product Manager at TAP commented: “We were approached by an existing customer to produce a system capable of consistently processing batches of a highly concentrated vaccine stock in vials, while keeping their staff safe from unnecessary exposure to this material. The fill-it fulfils these needs as the system is manufactured using stainless steel to prevent corrosion and potential routes of contamination such as rust spots. In addition, the electronics have been coated so that hydrogen peroxide vapour (one of the most effective sterilization methods) can be used without affecting the fill-it’s performance.”

Guy added: “The combination of containment and decontamination capabilities, as well as its routine use in a major vaccine production facility, demonstrates to any safety-conscious vaccine manufacturer that installing a stainless steel fill-it system is an excellent investment.”


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