Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Reaction Monitoring Experiments for Spinsolve Benchtop NMR Spectrometers

Published: Tuesday, July 22, 2014
Last Updated: Tuesday, July 22, 2014
Bookmark and Share
Magritek have demonstrated the use of their spectrometer to perform and monitor chemical reactions on-line.

As costs for energy and raw materials continue to rise, it becomes more critical for chemists to be able to mimic a reaction or to quantify the parameters required to produce a final product without the difficulty and expense of using production facilities. To be able to recreate a production process on a lab bench is therefore highly desirable for many chemists.

The Magritek Spinsolve high-resolution benchtop NMR spectrometer is a device that suits these demands and can be installed directly in a fume hood of a chemistry lab to monitor the progress of chemical reactions on-line. Reactants can be pumped in continuous mode from the reactor to the magnet and back using standard PTFE tubing.

The reaction itself can be carried out at temperatures of up to about 100 °C. When the reaction mixture is pumped through the bore of the magnet using 2 mm o. d. PTFE tubing, it naturally cools down to 30 °C or lower as it flows along the length of the tubing at room temperature. For reactions where maintaining the elevated temperature is critical, Magritek has put together a simple but effective flow set-up for on-line monitoring. It comprises a Dewar of 5 mm o. d. and 2.25 mm i. d. that is mount¬ed in the bore of the Spinsolve to minimise any heat transfer from the flowing sample to the magnet. The pump, which can be set to operate in continuous or stop-flow mode to acquire points with a time resolution of about 15 seconds, is placed in the flow-loop after the magnet in order to minimise the tubing length that goes from the reactor to the sensitive volume of the Spinsolve.

This approach to reaction monitoring has been demonstrated on a number of classical chemical reactions. For example, acetalisation is a common reaction in organic synthesis where an acetal is produced from an aldehyde and an alcohol. In the example here, acetaldehyde reacts with methanol to produce acetaldehyde dimethyl acetal. The reaction was performed in DMSO to prevent evaporation. With data being collected every fifteen seconds over a total period of one hour, the user could follow waterfall plots to show the decrease of acetaldehyde as it was used up together with the corresponding rise of the acetaldehyde dimethyl acetal.

These and many other reaction systems are described in the growing library of applications notes and case studies which are freely available for downloading from the Magritek web site where you can also obtain full details of the Spinsolve benchtop NMR spectrometer and the full range of analytical products from Magritek.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More Than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

University Uses Magritek Benchtop NMR to Teach Organic Chemistry
Magritek reports on the benefits of their Spinsolve Benchtop NMR spectrometer for teaching practical organic chemistry to undergraduate students at Cleveland State University in Ohio.
Tuesday, July 05, 2016
Magritek Benchtop Spinsolve Used to Teach Students How to Apply NMR for Spectroscopic Characterization
Magritek report on the use of their Spinsolve Benchtop NMR spectrometer in the practical teaching of organic chemistry students at Tarrant County College in Fort Worth, Texas.
Wednesday, February 10, 2016
Benchtop NMR for Research and Teaching
Magritek reports on how the Chemistry Department at Durham University is applying the Spinsolve benchtop NMR for research and teaching.
Wednesday, September 30, 2015
Reaction Monitoring Research Using the Spinsolve Benchtop NMR System
Reaction monitoring studies in the Cronin Group in the Chemistry Department of the University of Glasgow.
Saturday, February 14, 2015
Rangatira Increases Stake in Magritek
Investment reflects Rangatira’s aim to invest in growing, internationally competitive New Zealand businesses.
Tuesday, October 14, 2014
Scientific News
Liquid Biopsies: Miracle Diagnostic or Next New Fad?
Thanks to the development of highly specific gene-amplification and sequencing technologies liquid biopsies access more biomarkers relevant to more cancers than ever before.
Flu Vaccine May Reduce Risk of Death For Type 2 Diabetes Patients
Researchers at Imperial College London have suggested that the vaccine may have substantial benefits for patients with long-term conditions.
Cancer Gene-Drug Combinations Ripe for Precision Medicine
The study aims to expand the number of cancer gene mutations that can be paired with a precision therapy.
Porphyrins as Catalysts in Scalable Organic Reactions
This review covers the most relevant scalable porphyrin-catalysed procedures, showing how these compounds represent broad applications in chemistry.
CDC Updates Zika Recommendations
CDC has issued updated Zika recommendations and guidance for healthcare providers with a focus on sexual transmission.
Exploiting Malaria’s Achilles’ Heel
Researchers have uncovered an Achilles' heel in malaria's anti-drug treatment arsenal that could lead to a disease cure.
Genome of 6000-Year-Old Barley Sequenced
Researchers have successfully sequenced the genome of Chalcolithic barley grains for the first time.
3D Models May Yield Ovarian Cancer Insights
Researchers are developing new tools to decipher ovarian cancer developments through a 3D printing technology.
Targeting BRAF Mutations in Thyroid Cancer
Treating metastatic thyroid cancer patients harboring a BRAF mutation with vemurafenib showed anti-tumor activity in a third of patients.
Plant Compounds Fight Together Against Colon Cancer
Research shows treating colon cancer cells with curcumin, then silymarin is more effective than treatment with each individually.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!