Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Stem Cells from Nerves Forming Teeth

Published: Wednesday, July 30, 2014
Last Updated: Wednesday, July 30, 2014
Bookmark and Share
Findings published in the scientific journal Nature.

Researchers at Karolinska Institutet have discovered that stem cells inside the tooth's soft parts have an unexpected origin, namely nerves. The findings published in the scientific journal Nature and contribute to new knowledge about how the teeth are formed, how they grow and how they can repair themselves.

Our health and quality of life is closely linked to how our teeth feel. With age, the teeth more susceptible to infections, wear and damage, and it is an important duty of care to help people maintain good dental health. It is known that the tooth alive soft parts, the pulp, in addition to connective tissue, blood vessels and nerves also contains a small reservoir of stem cells. These stem cells can repair the tooth after injury by contributing to the formation of both hard and soft dental tissue. Researchers have long discussed the stem cell origin. By studying teeth in mice, the researchers behind the new study have been able to follow individual cells' fate.

We have identified a previously unknown type of stem cells, which unexpectedly belong to the nerves in the tooth - the nerves that normally associated with the most extreme tooth pain sensitivity, says Kaj Fried at the Department of Neuroscience , one of the leaders of the study.

The researchers discovered that young cells which are initially part of the nerve support cells, called glial cells, leaving the nerves early in fetal development. The cells replace the identity and becomes both connective tissue cells in the dental pulp, and to odontoblasts, the cells that produce the hard dentine during enamel. Today it is not possible to develop new teeth in adults, but the discovery of a new type of stem cells contributes in important ways to the knowledge and technology required for it will eventually be possible.

The fact that stem cells are available in the nerves are fundamentally very important and not unique to the tooth. Our results suggest that the peripheral nerves, which of course are virtually everywhere, can serve as important stem cell reservoirs. From here, multipotent stem cells leave the nerves and help to heal and regenerate tissue in various parts of the body, says Igor Adameyko at the Department of Physiology and Pharmacology , who along with Kaj Fried responsible for the study.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More Than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Different Cell Mechanisms Behind Regenerated Limbs
Scientists at Karolinska Institutet have discovered that two separate species of salamander differ in the way their muscles grow back in lost body parts.
Tuesday, November 26, 2013
New European Vaccine Initiative
Leading organisations have joined forces to rapidly assess and communicate the benefits and risks of vaccines.
Tuesday, November 26, 2013
Synthetic mRNA can Induce Self-Repair and Regeneration of the Infarcted Heart
A team of scientists has instructing injured hearts in mice to heal by expressing a factor that triggers cardiovascular regeneration driven by native heart stem cells.
Monday, September 16, 2013
Technological Breakthrough Paves the Way for Better Drugs
Researchers have developed the first method for directly measuring the extent to which drugs reach their targets in the cell.
Monday, July 08, 2013
Possible Goal for New Tuberculosis-Vaccine Identified
A new study shows for the first time the essential role of the molecule SOCS3 in the control of Tuberculosis.
Monday, July 08, 2013
Trackable Drug-Filled Nanoparticles - a Potential Weapon against Cancer
Tiny particles filled with a drug could be a new tool for treating cancer in the future.
Monday, March 04, 2013
Learning the Alphabet of Controlling Gene Expression
Scientists at Karolinska Institutet have made a large step towards the understanding of how human genes are regulated.
Monday, January 21, 2013
New Hope for Setback-dogged Cancer Treatment
Researchers at Karolinska Institutet announce breakthrough in the study of how IGF-1 receptor-binding antibodies can help those with cancer.
Wednesday, November 28, 2012
The 2012 Nobel Prize in Physiology or Medicine
The Nobel Assembly at Karolinska Institutet has decided to award the Nobel Prize jointly to John B. Gurdon and Shinya Yamanaka for the discovery that mature cells can be reprogrammed to become pluripotent.
Tuesday, October 09, 2012
Possible New Therapy for the Treatment of a Common Blood Cancer
Research from Karolinska Institutet shows that sorafenib, a drug used for advanced cancer of the kidneys and liver, could also be effective against multiple myeloma.
Friday, September 07, 2012
New Findings on the Formation of Body Pigment
The skin's pigment cells can be formed from completely different cells than has hitherto been thought, a new study from the Swedish medical university Karolinska Institutet shows. The results, which are published in the journal Cell, also mean the discovery of a new kind of stem cell.
Thursday, October 22, 2009
Cell-IQ® Cell Imaging System Aids Fertility Research at Karolinska
Cell-IQ® platform helps investigate mechanisms of infertility and oocyte maturation, and for characterization of human embryonic stem cell lines.
Thursday, July 09, 2009
Identical Twins Not as Identical as Believed
The finding published by American, Swedish, and Dutch scientists may be of great significance for research on hereditary diseases and for the development of new diagnostic methods.
Tuesday, February 19, 2008
Stem Cell Research Aims to Tackle Parkinson's Disease
New ways to grow brain cells in the laboratory could eventually provide a way to treat Parkinson's disease, scientists say.
Wednesday, January 23, 2008
Stem Cell Team Wins 2007 Nobel for Medicine
Stem cell researchers Mario Capecchi, Martin Evans and Oliver Smithies won the 2007 Nobel prize for medicine or physiology for their work on gene changes in mice using embryonic cells.
Tuesday, October 09, 2007
Scientific News
The Changing Tides of the In Vitro Diagnostics Market
With the increasing focus in personalized medicine, diagnostics plays a crucial role in patient monitoring.
LaVision BioTec Reports on the Neuro Research on the Human Brain After Trauma
Company reports on the work of Dr Ali Ertürk from the Institute for Stroke and Dementia Research at LMU Munich.
NIH Study Shows No Benefit of Omega-3 Supplements for Cognitive Decline
Research was published in the Journal of the American Medical Association.
Less May Be More in Slowing Cholera Epidemics
Mathematical model shows more cases may be prevented and more lives saved when using one dose of cholera vaccine instead of recommended two doses.
Investigating the Vape
Expert independent review concludes that e-cigarettes have potential to help smokers quit.
NIH Launches Human RSV Study
Study aims to understand infection in healthy adults to aid development of RSV medicines, vaccines.
Researchers Discover Synthesis of a New Nanomaterial
Interdisciplinary team creates biocomposite for first time using physiological conditions.
Poor Survival Rates in Leukemia Linked to Persistent Genetic Mutations
For patients with an often-deadly form of leukemia, new research suggests that lingering cancer-related mutations – detected after initial treatment with chemotherapy – are associated with an increased risk of relapse and poor survival.
Flu Remedies Help Combat E. coli Bacteria
Physiologists from the University of Zurich have now discovered why the intestinal bacterium Escherichia coli (E. coli) multiplies heavily and has an inflammatory effect.
Marijuana Genome Unraveled
A study by Canadian researchers is providing a clearer picture of the evolutionary history and genetic organization of cannabis, a step that could have agricultural, medical and legal implications for this valuable crop.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!