Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

MU Researchers Discover Protein's Ability To Inhibit HIV Release

Published: Wednesday, August 27, 2014
Last Updated: Wednesday, August 27, 2014
Bookmark and Share
TIM-family proteins have the ability to block the release of HIV and other viruses.

A family of proteins that promotes virus entry into cells also has the ability to block the release of HIV and other viruses, University of Missouri researchers have found.

“This is a surprising finding that provides new insights into our understanding of not only HIV infection, but also that of Ebola and other viruses,” said Shan-Lu Liu, MD, PhD, associate professor in the MU School of Medicine’s Department of Molecular Microbiology and Immunology.

The study was recently published in the Proceedings of the National Academy of Sciences. Liu, the corresponding author of the study, is also an investigator with the Christopher S. Bond Life Sciences Center at MU.

According to estimates from the Centers for Disease Control and Prevention, more than one million Americans currently are living with HIV infection. AIDS, which stands for acquired immunodeficiency syndrome, is a condition characterized by progressive failure of the immune system. It is caused by the human immunodeficiency virus type 1 (HIV-1).

When HIV-1 or any virus infects a cell, it replicates and spreads to other cells. One type of cellular protein — T cell immunoglobulin and mucin domain, or TIM-1 — has previously been shown to promote entry of some highly pathogenic viruses into host cells. Now, the MU researchers have found that the same protein possesses a unique ability to block the release of HIV-1 and Ebola virus.

“This study shows that TIM proteins keep viral particles from being released by the infected cell and instead keep them tethered to the cell surface,” said Gordon Freeman, PhD, an associate professor of medicine with Harvard Medical School’s Dana-Farber Cancer Institute, who was not affiliated with the study. “This is true for several important enveloped viruses including HIV and Ebola. We may be able to use this insight to slow the production of these viruses.”

Under the supervision of Liu, Minghua Li, a graduate student in the MU Pathobiology Area Program, performed a series of experiments that revealed the protein’s ability to inhibit HIV-1 release, resulting in diminished viral production and replication.

HIV-1 attacks cells that are vital to the body’s immune system, such as T cells. These white blood cells play an important role in the body’s response to infection, but HIV-1 disrupts the cells’ ability to fight back against infection. When the virus enters a host cell, it infects the cell and replicates, producing viral particles that spread to and infect other cells. The researchers found that as the viral particles attempt to bud from, or leave, the infected cell, the TIM-family proteins located on the surface of the cell can attach to lipids on the surface of the viral particle.

These lipids – known as phosphatidylserine (PS) — are normally present on the inner side of the cellular membrane but can be exposed to the outer side upon viral infection. When the TIM-family proteins come in contact with PS, the viral particle becomes attached to the host cell, keeping the particle from being released from the cell. Because TIM-family proteins and PS are present on the surface of the cell and the viral particle, the viral particles get stuck to one another, forming a network of viral particles that accumulate on the surface of the host cell, rather than being released to infect other cells.

By using molecular, biochemical and electron microscopic approaches, the researchers observed the TIM and PS interactions in human cells. The next step is for the researchers to study the biological significance of TIM-family proteins in animals and patients and to determine the fate of the infected cell once it accumulates a buildup of viral particles.

“We are not at the point to draw a conclusion as to whether this is a positive or a negative factor,” Liu said. “However, this discovery furthers our ultimate goal of understanding the biology of TIM-family proteins and potentially developing applications for future antivirus therapies.”

The study, “TIM-Family Proteins Inhibit HIV-1 Release,” is supported in part by the National Institutes of Health and the University of Missouri. In addition to Liu and Li, researchers include Eric Freed, PhD, senior investigator with the National Cancer Institute (NCI) HIV Drug Resistance Program; Sherimay Ablan, biologist with the NCI HIV Drug Resistance Program; Marc Johnson, PhD, associate professor in the MU Department of Molecular Microbiology and Immunology; Chunhui Miao and Matthew Fuller, graduate students in the MU Department of Molecular Microbiology and Immunology; Yi-Min Zheng, MD, MS, senior research specialist with the Christopher S. Bond Life Sciences Center at MU; Paul Rennert, PhD, founder and principal of SugarCone Biotech LLC in Holliston, Massachusetts; and Wendy Maury, PhD, professor of microbiology at the University of Iowa.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More Than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Creating Embryos with 'Heteroplasmy'
New discovery in genetic research could lead to treatments for mitochondrial diseases.
Wednesday, August 24, 2016
Fly Study into Therapies for HVP-Induced Cancer
Fruit flies may help scientists understand the mechanism by which HPV can cause cancer as well as identify potential drug treatments.
Monday, August 22, 2016
Bacteria Implicated in Reproductive Disorders
Bacteria harbored in the male reproductive system may be responsible for prostatitis.
Thursday, March 17, 2016
Researchers Discover A New Mechanism of Proteins to Block HIV
Certain IFITM proteins block and inhibit cell-to-cell transmission of HIV.
Tuesday, September 29, 2015
Scientists Successfully Edit Genes of Dengue Fever Mosquitoes
This research could lead to methods for preventing mosquito-borne diseases.
Monday, September 07, 2015
Unraveling the Elusive Structure of HIV Protein
Snapshots of HIV virus’ proteins may help design new ways to fight the disease.
Monday, July 06, 2015
Key Component in Protein that Causes Cystic Fibrosis Identified
Scientists hope that this finding may lay the foundations for the development of new medications and improved therapies.
Thursday, May 21, 2015
Green Tea Extract and Exercise Hinder Progress of Alzheimer’s
A study led by University of Missouri researchers has determined that a compound found in green tea, and voluntary exercise, slows the progression of the disease in mice and may actually reverse its effects.
Thursday, May 07, 2015
New Transitional Stem Cells Discovered
New stem cells are easier to manipulate, could help future research on reproductive problems.
Friday, April 17, 2015
MU Scientists Successfully Transplant, Grow Stem Cells in Pigs
New line of pigs do not reject transplants, will allow for future research on stem cell therapies.
Saturday, June 07, 2014
Stem Cells Successfully Transplanted and Grown in Pigs
New line of pigs do not reject transplants, which will allow for future research on stem cell therapies.
Thursday, June 05, 2014
Adult Stem Cells Could Hold Key to Creating Cure for Type 1 Diabetes
Combining bone marrow cells with new drug restores insulin production.
Tuesday, June 04, 2013
MU Scientists Build Harness for Powerful Radiation Cancer Therapy
Scientists created a gold nanoparticle that can transport powerful radioactive particles directly to tumors for treatment.
Thursday, February 07, 2013
Identical DNA Codes Discovered in six Plant Species safter 32 billion searches
Analyzing massive amounts of data officially became a national priority recently when the White House Office of Science and Technology Policy announced the Big Data Research and Development Initiative. A multi-disciplinary team of University of Missouri researchers rose to the big data challenge when they solved a major biological question by using a groundbreaking computer algorithm to find identical DNA sequences in different plant and animal species.
Tuesday, April 10, 2012
Achieving Coexistence of Biotech, Conventional and Organic Foods in the Marketplace
Meeting at Vancouver, Canada, October 26-28, 2011; GMCC Coexistence Conference
Thursday, April 21, 2011
Scientific News
Mass Spec Technology Drives Innovation Across the Biopharma Workflow
With greater resolving power, analytical speed, and accuracy, new mass spectrometry technology and techniques are infiltrating the biopharmaceuticals workflow.
One Step Closer to Precision Medicine for Chronic Lung Disease Sufferers
A study led by University of North Carolina at Chapel Hill, and National Jewish Health, has provided evidence of links between SNPs and known COPD blood protein biomarkers.
Gene Regulation in Brain May Explain Repetitive Behaviors in Rett Syndrome Patients
The research could be a key step in developing treatments to eliminate symptoms that drastically impair the quality of life in Rett patients.
Heart Arrhythmia Caused by Mosaic of Mutant Cells
Researchers have solved the genetic mystery of an infant suffering from heart arrhythmia.
Iron Nanoparticles Make Immune Cells Attack Cancer
Researchers accidentally discover that nanoparticles invented for anemia treatment can trigger the immune system’s ability to destroy tumor cells.
Crispr Toolbox Expanded By Protein
Researchers have shown a newly discovered CRISPR protein has two distinct RNA cutting activities.
CES Score May Predict Response to Cancer Treatment
Researchers identify new type of biomarker that helps predict prognosis and response to several types of cancer treatment.
Uncovering Cancer’s ‘Invisibility Cloak’
Researchers discover cancer cell mechanism to become invisible to the body's immune system.
Genetic Impact of Endurance Training
Research has found that endurance training changes genetic activity in thousands of genes, giving rise to large number of altered RNA variants.
Treating Sepsis with Marine Mitochondria
Mitochondrial alternative oxidase from a marine animal combats bacterial sepsis.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!