Automated Online Nanoparticle Sizing for Process Monitoring

The new analyzer provides timely and reliable data that enables tracking of processes in the sub-micron size range, such as emulsification, dispersion, milling and homogenization, while at the same time eliminating the delays and inefficiencies associated with manual analysis. The net result is improved process understanding, streamlined process development and improved product quality. 

In many applications, particle size is a critical determinant of nanoparticle performance. When producing nanoparticles or droplets via size reduction, detecting the endpoint of a batch process or tracking stable conditions during continuous production in a timely manner is important. Suitable Process Analytical Technology (PAT) can help understand the dynamic behavior of the process, enabling reduction in the amount of testing during development and improving consistency of manufacturing operations.

“The introduction of an online DLS system is an important advance for those developing and manufacturing nanoparticles” said Alon Vaisman, Product Development Manager, Process Systems at Malvern Instruments. “The ability to measure particle size in a timely way, using a well-established and popular method enables more precise trending of size changes, supporting faster, more robust process development and competitive well-controlled manufacture, whether batch or continuous”.

The new Zetasizer AT builds on Malvern’s market-leading Zetasizer Nano DLS technology, and in-house expertise in engineering trusted online instrumentation. Mobile, fully automated, computer controlled sampling system enables measurements across the size range 1 nm to 1000 nm and can be easily operated in research laboratories as well as on the manufacturing floor. Versatile automation control and integration software, Malvern Link II provides a convenient user interface and ability to directly report measurement results into a remote system.