Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Stem Cell Research Could aid Male Infertility

Published: Wednesday, July 12, 2006
Last Updated: Wednesday, August 09, 2006
Bookmark and Share
Study helps scientists to understand more about how animals produce sperm.

Scientists have shown that sperm grown from embryonic stem cells can be used to produce offspring.

The experiment was carried out using mice and produced seven babies, six of which lived to adulthood.

The study, reported Monday July 10, in the academic journal Developmental Cell, helps scientists to understand more about how animals produce sperm. This knowledge has potential applications in the treatment of male infertility.

Karim Nayernia, who has just taken up a post as Professor of Stem Cell Biology at Newcastle University, led the research while in his previous position at Georg-August University in Gotingen, Germany, with Prof. Dr Wolfgang Engel and colleagues from Germany and the UK, including Dr. David Elliott from Newcastle University's Institute of Human Genetics.

Prof Nayernia, of the Newcastle-Durham-NHS Institute for Stem Cell Biology and Regenerative Medicine, and his team describe in their paper how they developed a strategy for generating mature sperm cells in the laboratory using embryonic stem cells from mice. They then went on to test whether this sperm would function in real life.

The team isolated stem cells from a blastocyst, an early-stage embryo that is a cluster of cells only a few days old.

These cells were grown in the laboratory and screened using a special sorting machine. Some had grown into a type of stem cell known as ‘spermatogonial stem cells’, or early-stage sperm cells.

The spermatogonial cells were singled out, then genetically marked and grown in the laboratory.

Some of them grew into cells resembling sperm, known as gametes, which were themselves singled out and highlighted using a genetic marker.

The sperm that had been derived from the embryonic stem cells was then injectd into the female mouse eggs and grown into early-stage embryos.

The early-stage embryos were transplanted into the female mice which produced seven babies. Six developed into adult mice.

Prof Nayernia, who originally hails from Shiraz in Southern Iran, said, "This research is particularly important in helping us to understand more about spermatogenesis, the biological process in which sperm is produced. We must know this if we are to get to the root of infertility."

"If we know more about how spermatogonial stem cells turn into sperm cells, this knowledge could be translated into treatments for men who are unable to produce mature sperm, although this is several years down the line."

"For example, we could isolate a patient’s spermatagonial cells using a simple testicular biopsy, encourage them in the laboratory into becoming functional sperm and transplant them back into the patient."

The findings could also inform a field of stem cell research known as nuclear transfer, or therapeutic cloning, which aims to provide tailor-made stem cells to aid disease therapy and infertility. Sperm cells could potentially be created using this method.

Although previous studies have shown that embryonic stem cells grown in the laboratory can become germ cells that give rise to cells resembling sperm cells or gametes.

Prof Nayernia added, "Spermatogonial stem cells are extremely promising and more research is needed to establish their full potential."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More Than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Rapid Gene Test for Mitochondrial Disease
Researchers at Newcastle University have developed a genetic test providing a rapid diagnosis of mitochondrial disorders, identifying the first patients with inherited mutations in a new disease gene.
Friday, July 08, 2016
Losing the Fight Against Antibiotic Resistance
Tackling antibiotic resistance on only one front is a waste of time because resistant genes are freely crossing environmental, agricultural and clinical boundaries, new research has shown.
Thursday, February 18, 2016
Mitochondria Shown to Trigger Cell Ageing
An international team of scientists has for the first time shown that mitochondria, the batteries of the cells, are essential for ageing.
Friday, February 05, 2016
Funding from Charity for New Treatments to Silence Tinnitus
Researchers are currently conducting a clinical trial of a drug for tinnitus.
Friday, February 06, 2015
Damaged Protein Could be Key to Premature Ageing
Scientists have found that the condition of key proteins in the mitochondria -the batteries of cells- could be used to predict, and eventually treat premature ageing. And restricting diet could be one way of making this happen.
Wednesday, May 14, 2014
Stem Cell Firm Selects Newcastle for European Base
RNL Bio has signed an initial 12 month tenancy agreement for a unit at the ‘Cels at Newcastle’ bio-incubator at Newcastle University's Medical School.
Friday, February 08, 2008
Scientific News
Liquid Biopsies: Miracle Diagnostic or Next New Fad?
Thanks to the development of highly specific gene-amplification and sequencing technologies liquid biopsies access more biomarkers relevant to more cancers than ever before.
Core-Shell Columns in HPLC: Food Analysis Applications
Explore the most recent applications of core-shell columns in food analysis.
Review of the Analysis of Haemoglobin A1c for Diabetes Diagnostics
This paper aims to clarify methods, units, quality requirements, reference and cutoff limits for hemoglobin A1c (HbA1c) and ratio of blood glucose/HbA1c on the basis of the results from Finnish quality control surveys by comparing them to the literature.
Colon Cancer Blocked in Mice
Case Western Reserve University Researchers block common type of colon cancer tumour in mice, laying groundwork for human clinical trial.
New Centre Offers Ultra-Speed Protein Analysis
UW-Madison researchers to establish development centre for next-gen protein measurement technologies.
Disrupting Tumour-Promotion in Humans
Researchers have modified an existing protein to represses a specific cancer-promoting ‘message’ within cells.
Protein Nanocages Could Improve Drug Design and Delivery
HHMI scientists have designed and built 10 large protein icosahedra that are similar to viral capsids that carry viral DNA.
Connectome Map More Than Doubles Human Cortex’s Known Regions
Researchers at NIH have developed software that automatically detects the “fingerprint” of each of these areas in an individual’s brain scans.
Discovered Through ‘Big Data’ Analysis
Researchers at the SBP have identified over 100 new genetic regions that affect the immune response to cancer.
Human Stem Cells to Rapidly Generate Bone, Heart Muscle
A new study shows that combining positive and negative signals can quickly and efficiently steer stem cells down complex developmental pathways to become specialized tissues that could be used in the clinic.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!