Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Variation in Three Genes Influences Risk of Age-Related Macular Degeneration

Published: Thursday, September 07, 2006
Last Updated: Thursday, September 14, 2006
Bookmark and Share
Researchers discover a common, noncoding variant in the CFH gene that is associated with AMD.

Researchers in Boston have discovered a common, noncoding variant in the Complement Factor H (CFH) gene that is associated with age-related macular degeneration (AMD).

Their analyses combine this variant with all previously reported variants to estimate individual risk of advanced AMD.

They observed additive accumulation of risk from alleles at these three genes, including CFH on chromosome 1, complement factor B (BF) and complement component 2 (C2) genes on chromosome 6, and the LOC gene on chromosome 10.

They estimate that genotypes related to five variants in these three genes explain about half the sibling risk of AMD in the study population. Results are published online in Nature Genetics

They studied 2,172 unrelated European-descended individuals 60 years of age or older, who were diagnosed on the basis of ocular examination and ocular photography (1,238 affected individuals and 934 controls).

Affected individuals were defined as those having advanced AMD related to visual loss with either geographic atrophy (dry) or neovascular (wet) disease.

Controls were individuals without AMD. The mean age was 74 for controls (54% female) and 78 years for affected individuals (55% female).

Both Illumina and Sequenom methods were used to genotype about 1540 single nucleotide polymorphisms.

"The overall implication of this study is that depending on your genotype related to these five variants in three genes, and most likely more to be discovered, preventive and therapeutic drug targets may be better designed and tailored to an individual's need, ie., personalized medicine," said Johanna M. Seddon, M.D., Director of the Epidemiology Unit and Macular Degeneration specialist at the Massachusetts Eye and Ear Infirmary, and Associate Professor at Harvard Medical School.

This study evaluated a large number of samples from individuals with advanced AMD, including both geographic atrophy or "dry" AMD, and neovascular disease or "wet" AMD, which cause visual loss.

It is noteworthy that no differences were found between these subtypes of advanced AMD with respect to the variations found in the genes.

Dr. Seddon and her colleagues previously reported that the heritability of AMD is high (46% to 71%) in a large US cohort of elderly twins (Arch Ophthalmol 2005), and that another common CFH variant as well as smoking and higher body mass index are independently related to advanced AMD (Human Heredity 2006).

A decade ago they reported the increased risk of AMD attributable to cigarette smoking (JAMA 1996).

They also found that high body mass index is a risk factor for progression of the disease. (Arch Ophthalmol 2003).


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,100+ scientific posters on ePosters
  • More Than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Doubling Down on Dengue
HMS researchers have discovered two ways a compound blocks dengue virus.
Tuesday, April 26, 2016
Fighting Early Stage Alzheimer's
Mouse study suggests possibility of curbing early synapse loss in Alzheimer’s.
Monday, April 04, 2016
Breaking the Chain
Compound prevents multidrug-resistant fungi from pumping out drugs.
Tuesday, February 23, 2016
Breaking Point
Hotspots for DNA breaks cluster in specific genes in developing neurons.
Wednesday, February 17, 2016
The Spice of Life
Scientists discover important genetic source of human diversity.
Tuesday, February 09, 2016
Cytoskeleton Crew
Findings confirm sugar's role in helping cancers survive by changing cellular architecture.
Tuesday, February 09, 2016
The Power of Three
Overlooked portion of cell “death receptor” critical in some cancers, autoimmune diseases.
Tuesday, February 09, 2016
‘Lifespan Machine’ Probes Cause of Aging
Findings suggest that aging has no single mechanism.
Wednesday, February 03, 2016
Photo Finish
Nanoparticles pair photodynamic and molecular therapies against pancreatic cancer in mice.
Tuesday, January 26, 2016
High-fidelity CRISPR
Improved gene-editing tool has no detectable off-target mutations.
Thursday, January 07, 2016
Stem Cell Memory
Scientists find molecular key that prevents the conversion of adult cells into iPS cells.
Tuesday, January 05, 2016
Hit Parade
Researchers are generating a list of compounds that may lead to a trio of new therapeutics.
Tuesday, December 22, 2015
Stockpiling Proteins
New web-based tool allows researchers to measure protein dynamics in embryogenesis.
Wednesday, December 09, 2015
A Natural History of Neurons
Diverse mutations reveal lineage of brain cells.
Monday, October 05, 2015
The Final Word on STAP
Researchers fail to replicate STAP study; computational analysis reveals genomic inconsistency.
Monday, September 28, 2015
Scientific News
The Rise of 3D Cell Culture and in vitro Model Systems for Drug Discovery and Toxicology
An overview of the current technology and the challenges and benefits over 2D cell culture models plus some of the latest advances relating to human health research.
New NIH-EPA Research Centers to Study Environmental Health Disparities
Scientists will partner with community organizations to study these concerns and develop culturally appropriate ways to reduce exposure to harmful environmental conditions.
Structure of Essential Digestive Enzyme Uncovered
Using a powerful combination of techniques from biophysics to mathematics, researchers have revealed new insights into the mechanism of a liver enzyme that is critical for human health.
Air Pollution Linked to Heart Disease
10-year project revealed air pollutants accelerate plaque build-up in arteries to the heart.
Getting a Better Look at How HIV Infects and Takes Over its Host Cells
A new approach, developed by a team of researchers led by The Rockefeller University and The Aaron Diamond AIDS Research Center (ADARC), offers an unprecedented view of how a virus infects and appropriates a host cell, step by step.
Following Tricky Triclosan
Antibacterial product flows through streams, crops.
Vitamin A May Help Improve Pancreatic Cancer Chemotherapy
The addition of high doses of a form of vitamin A could help make chemotherapy more successful in treating pancreatic cancer, according to an early study by Queen Mary University of London (QMUL).
Poverty Marks a Gene, Predicting Depression
New study of high-risk teens reveals a biological pathway for depression.
World’s Largest Coral Gene Database
‘Genetic toolkit’ will help shed light on which species survive climate change.
A Boost for Regenerative Medicine
Growing tissues and organs in the lab for transplantation into patients could become easier after scientists discovered an effective way to produce three-dimensional networks of blood vessels, vital for tissue survival yet a current stumbling block in regenerative medicine.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,100+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!