Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Thermo’s Rhombix Protein Crystallization Platform Chosen by UK MPSI

Published: Wednesday, September 13, 2006
Last Updated: Wednesday, September 13, 2006
Bookmark and Share
Membrane Protein Structure Initiative set to increase throughput and data management capabilities.

Thermo Electron Corporation has announced the purchase of three fully integrated Rhombix™ protein crystallization systems by the Membrane Protein Structure Initiative (MPSI).

A consortium of eight UK universities and institutions, the MPSI is funded by the Biotechnology and Biological Sciences Research Council (BBSRC).

The MPSI has been working to develop high throughput methods for the crystallization and structural determination of specific integral membrane protein targets.

Integrating the latest technologies for experimental design and setup, advanced imaging, and data management, Thermo’s Rhombix systems are designed to significantly aid the MPSI’s crystallization programme.

The Rhombix systems will be installed at the MPSI laboratories at the University of Leeds, the University of Glasgow and the Diamond Synchrotron, where Imperial College London and Diamond are establishing a Membrane Protein Laboratory in a joint venture.

The MPSI’s strategy is to address a target list of membrane proteins, in particular those associated with ion channels and transporters.

Both groups of proteins have substantial medical relevance as their mutation or malfunction can be linked to the initiation and progression of many disease types and are thus regarded as important therapeutic targets.

Professor Neil Isaacs, Department of Chemistry, Glasgow Biomedical Research Centre commented, "We have an enormous task ahead of us with a phenomenal number of proteins to crystallize and a group of proteins that notoriously pose a significant crystallization challenge."

"After evaluating a range of vendor options, we felt the Thermo’s Rhombix platforms would best suit our needs."

"They will help us develop fully automated methods but also, more importantly maintain data quality while optimizing our experimental parameters for each protein."

"Having the ability to automatically track experiments from start to finish will provide us with a wealth of experimental information that we can store for future crystallizations."

Thermo’s Rhombix system is designed to integrate and control liquid handling instrumentation for accurate drop-making and screen preparation and the Rhombix Vision hardware automatically handles, stores and images plates using multimode imaging technologies for image quality and crystal visualization.

Furthermore, as a data-centric solution, experimental details and automation settings are recorded and stored in one centralized database, for advanced data mining and monitoring.

Christopher McNary, vice president & general manager, laboratory automation solutions for Thermo stated, "We are proud to be associated with the distinguished research taking place at the MPSI."

"The Rhombix systems will enable the researchers to further develop and optimize their high throughput methodologies."

He continued, "The key to this system is the advanced Rhombix software as it brings together all the components of the crystallization platform, such as experimental set-up, advanced imaging scheduling, and data capture and analysis, giving the users an intuitive and easy-to-use interface."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More Than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Thermo and RITT Program Announce Collaborative R&D Agreement
The RITT Industrial BioDevelopment Laboratory has been equipped with over $1,000,000 (Canadian) of Thermo laboratory equipment.
Wednesday, November 08, 2006
Thermo Announces Process Laboratory Automation Seminars
The seminars focus on how advances in laboratory automation, using LIMS, can act as a key enabler for improved productivity.
Wednesday, November 08, 2006
Thermo Announces Process Laboratory Automation Seminars
The seminars focus on how advances in laboratory automation, using Laboratory Information Management Systems (LIMS), can act as a key enabler for improved productivity and quality in the process industry.
Monday, November 06, 2006
Thermo Expands Its Informatics Presence in Saudi Arabia
The helpdesk will offer timely and reliable local language technical assistance.
Monday, October 30, 2006
Thermo’s High Resolution GC/MS System Satisfies Regulatory Requirements for Low Detection Limits of Dioxins and Furans
The system features Multiple Ion Detection allowing scan-to-scan monitoring.
Monday, October 30, 2006
Thermo’s Antaris™ Target Blend Analyzer Wins Best Micro- and Nanotechnologies 2006 Award
Thermo’s Antaris Target near-infrared blend analyzer enables real-time monitoring of tablet manufacturing blending processes.
Tuesday, October 03, 2006
Thermo’s iCAP 6000 Series Wins Gold Instrument Business Outlook Industrial Design Award
Thermo’s iCAP 6000 Series features a close coupled optical design with orthogonal fore optics.
Monday, September 25, 2006
Thermo Wins Omega Award for Service Excellence for Second Consecutive Year
The award presented to Thermo included two categories: Installation Service Representative and Field Service Engineer.
Thursday, September 21, 2006
Thermo Announces Major Laboratory Informatics Conference
This annual user conference provides a chance to share industry perspectives and changing business requirements.
Tuesday, August 29, 2006
Thermo Offers Comprehensive Spectroscopic Solutions Seminars
This seminar provides existing and new users with the necessary skills to operate Thermo’s extensive range of spectroscopic.
Monday, August 21, 2006
Thermo Ships 1000th ARL 4460 Optical Emission Spectrometer
The milestone order was received from Voest Alpine Industrieanlagebau who purchased the instrument for Alchevsk Iron & Steel Works.
Tuesday, August 15, 2006
Thermo’s HCS WorkCell Selected by Emory University
Emory MLSC set to double throughput and expand assay range with Thermo’s compact high-content screening platform.
Thursday, July 06, 2006
Thermo Offers two Training Courses on the use of its iCAP 6000 Series
The courses have been developed to provide iCAP users with the necessary skills to operate these instruments efficiently.
Thursday, June 08, 2006
Thermo Electron's MS Technology Wins Top Award at PITTCON 2006
Editors in attendance voted Thermo's LTQ™ Orbitrap™ hybrid mass spectrometer the best new product introduction of the show.
Monday, March 27, 2006
Commercial-off-the-Shelf Solutions Highlight Thermo's Informatics Exhibit at Analytica
Thermo’s exhibit will feature laboratory information management systems and chromatography data systems.
Monday, February 13, 2006
Scientific News
Food Triggers Creation of Regulatory T Cells
IBS researchers document how normal diet establishes immune tolerance conditions in the small intestine.
Light Signals from Living Cells
Fluorescent protein markers delivered under high pressure.
Counting Cancer-busting Oxygen Molecules
Researchers from the Centre for Nanoscale BioPhotonics (CNBP), an Australian Research Centre of Excellence, have shown that nanoparticles used in combination with X-rays, are a viable method for killing cancer cells deep within the living body.
Therapeutic Approach Gives Hope for Multiple Myeloma
A new therapeutic approach tested by a team from Maisonneuve-Rosemont Hospital (CIUSSS-EST, Montreal) and the University of Montreal gives promising results for the treatment of multiple myeloma, a cancer of the bone marrow currently considered incurable with conventional chemotherapy and for which the average life expectancy is about 6 or 7 years.
Cellular 'Relief Valve'
A team led by scientists at The Scripps Research Institute (TSRI) has solved a long-standing mystery in cell biology by showing essentially how a key “relief-valve” in cells does its job.
Genomic Signature Shared by Five Types of Cancer
National Institutes of Health researchers have identified a striking signature in tumor DNA that occurs in five different types of cancer.
Protein Protects Against Flu in Mice
The engineered molecule doesn’t provoke inflammation and may hail a new class of antivirals.
Cat Stem Cell Therapy Gives Humans Hope
By the time Bob the cat came to the UC Davis veterinary hospital, he had used up most of his nine lives.
Crowdfunding the Fight Against Cancer
From budding social causes to groundbreaking businesses to the next big band, crowdfunding has helped connect countless worthy projects with like-minded people willing to support their efforts, even in small ways. But could crowdfunding help fight cancer?
Switch Lets Salmonella Fight, Evade Immune System
Researchers at the University of Illinois at Chicago have discovered a molecular regulator that allows salmonella bacteria to switch from actively causing disease to lurking in a chronic but asymptomatic state called a biofilm.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!