Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Stem Cells: Chemistry Paves way Toward Promising Therapies

Published: Monday, September 18, 2006
Last Updated: Monday, September 18, 2006
Bookmark and Share
Insights from the study could help guide similar adult stem cell transformations in other cell types in the future.

Chemists are developing insights and techniques in an effort to expand the therapeutic potential of stem cells, which includes possible treatments for Parkinson's disease, diabetes, spinal cord injury and other devastating conditions.

The American Chemical Society has explored some of these latest developments, including findings on the transformation potential of adult stem cells, during a special symposium, "Emerging Technologies: Stem Cells," on Thursday, Sept. 14, in San Francisco during the Society's 232nd national meeting.

All papers in this symposium, which begins at 1:30 p.m., have been presented at the Hilton San Francisco, Yosemite B.

Shown below are selected papers from this symposium:

Adult stem cells show wider potential than previously thought - Embryonic stem cells are the most versatile stem cells, capable of being transformed into any other cell type, depending on their desired therapeutic use.

Now, researchers at Northwestern University have found evidence that hematopoietic stem cells, a type of adult stem cell derived from the bone marrow that gives rise to blood cells, is capable of undergoing more diverse transformations than previously thought and could be transformed into a wide variety of tissue types, not just blood cells.

In recent laboratory tests, human megakaryocytes (bone marrow cells that produce blood platelets that are responsible for blood clotting) derived from adult hematopoietic stem cells were reprogrammed into neutrophil-like cells similar to the white blood cells that are responsible for fighting infections, according to study leader E. Terry Papoutsakis, Ph.D., a chemical engineer at the University.

Insights from this study could help guide similar adult stem cell transformations in other cell types in the future, he says.

Elasticity of tissue environment plays role in determining stem cell growth -Researchers at the University of Pennsylvania have shown that the elasticity of a stem cell's environment is a major determinant of what type of tissue the stem cell becomes.

In laboratory tests, Dennis Discher, Ph.D., and Adam Engler, Ph.D., grew mesenchymal stem cells (derived from adult bone marrow) in polymer hydrogels with either soft, medium or rigid elasticity.

Based on resulting cell shapes as well as messenger RNA and protein markers, stem cells grown in softer environments - such as brain tissue - tended to produce nerve-like cells; those grown in environments with medium elasticity - similar to muscle - produced muscle-like cells; and stem cells grown in more rigid environments - like bone - produced bone-like cells.

The study provides clues on how chemical and mechanical factors interact to influence stem cell growth, the researchers say. 

'Stretched' stem cells have potential to be transformed into blood vessel cells - Scientists have searched for years for a renewable cell source to craft blood vessels that can be used for heart bypass surgery and perform more like natural arteries.

Now, researchers at the University of California, Berkeley, have shown that mesenchymal stem cells from adult bone marrow can be repeatedly and mechanically stretched - in a manner similar to a taffy pull - into patterns that could potentially transform them into smooth muscle cells similar to blood vessel tissue.

These smooth muscle cells, which can expand and contract, could be used as a component of a tissue-engineered graft that may provide performance over conventional grafts that are used for bypass surgery, says study leader Kyle Kurpinkski, a doctoral candidate in the University's Department of Bioengineering.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,900+ scientific posters on ePosters
  • More Than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Detecting Mycotoxins in Beer
Scientists develop portable mycotoxin sensor to minimise risk of contamination.
Tuesday, November 08, 2016
Spotting Falsified, Degraded Medications
A team of researchers has developed a simple, inexpensive paper-based device to screen suspicious medications.
Monday, August 22, 2016
Frankfurter Fraud: Finding Out What’s In Your Hot Dog
Scientists have developed a technique to test the meat content of Frankfurters.
Friday, August 12, 2016
Portable Test Rapidly Detects Zika
To better diagnose and track the disease, scientists are now reporting a new $2 test that in the lab can accurately detect low levels of the virus in saliva.
Friday, July 01, 2016
Detecting Fake Parmesan Cheeses
Scientists report on a way to catch adulteration of the regional artisanal products.
Friday, May 20, 2016
Measuring The Airborne Toxicants Urban Bicyclists Inhale
Researchers analyze breath biomarkers to measure uptake of volatile organic compounds by bicyclists.
Friday, May 06, 2016
Vinegar Could Potentially Help Treat Ulcerative Colitis
Vinegar is the perfect ingredient for making tangy sauces and dressings. Now, researchers report that the popular liquid could also help fight ulcerative colitis, an inflammatory bowel disease that research suggests is related to the gut microbiome.
Monday, February 15, 2016
Sniffing Out Cancer
Scientists have been exploring new ways to “smell” signs of cancer by analyzing what’s in patients’ breath.
Thursday, October 01, 2015
New, Improved Approach To Mammograms
Detecting breast cancer in women with dense mammary tissues could become more reliable with a new mammogram procedure that researchers have now tested in pre-clinical studies of mice.
Friday, September 18, 2015
“Heat” From Chilli Peppers Could Help Kill Cancer Cells
Capsaicin, the compound responsible for chilis’ heat, is used in creams sold to relieve pain, and recent research shows that in high doses, it kills prostate cancer cells.
Friday, September 11, 2015
Preventing Drinking Water Contamination by Pharmaceuticals
In recent years, researchers have realized that many products, including pharmaceuticals, have ended up where they’re not supposed to be — in our drinking water.
Friday, September 11, 2015
Cheap Diagnostics with a Portable "Paper Machine"
Scientists have developed a cheap, portable system for point of care diagnostics for a range of infectious diseases, genetic conditions and cancer.
Monday, July 20, 2015
Microfluidic Device Mixes And Matches DNA For Synthetic Biology
Researchers have developed a microfluidic device that quickly builds packages of DNA and delivers them into bacteria or yeast for further testing.
Monday, July 06, 2015
Artificial Pancreas Controls Diabetes
Scientists are reporting the development of an implantable “artificial pancreas” that continuously measures a person’s blood sugar, or glucose, level and can automatically release insulin as needed.
Friday, July 03, 2015
Expanding the Code of Life With New “Letters”
Researchers have developed a new nucleotide pair that can be added to DNA, raising the possibility that entirely new proteins could be created for medical uses.
Friday, May 29, 2015
Scientific News
Big Genetics in BC: The American Society for Human Genetics 2016 Meeting
Themes at this year's meeting ranged from the verification, validation, and sharing of data, to the translation of laboratory findings into actionable clinical results.
Stem Cells in Drug Discovery
Potential Source of Unlimited Human Test Cells, but Roadblocks Remain.
Cancer Genetics: Key to Diagnosis, Therapy
When applied judiciously, cancer genetics directs caregivers to the right drug at the right time, while sparing patients of unnecessary or harmful treatments.
BGI Sequences Gingko Tree, Revealing Large, Highly Repetitive Genome
Researchers at BGI have sequenced the more than 10-gigabase ginkgo genome to find a high number of repetitive sequences as well as a number of gene clusters that appear to be involved in defense mechanisms.
Survey of New York City Soil Uncovers Medicine-Making Microbes
Microbes have long been an invaluable source of new drugs. And to find more, we may have to look no further than the ground beneath our feet.
Accelerating the Detection of Foodborne Bacterial Outbreaks
The speed of diagnosis of foodborne bacterial outbreaks could be improved by a new technique developed by researchers at the Georgia Institute of Technology.
Making Personalized Medicine a Reality
Groundbreaking technique developed at McMaster University is helping to pave the way for advances in personalized medicine.
Scientists Identify Unique Genomic Features in Testicular Cancer
The findings may shed light on factors in other cancers that influence their sensitivity to chemotherapy.
Top 10 Life Science Innovations of 2016
2016 has seen the release of some truly innovative products. To help you digest these developments, The Scientist have listed their top picks for the year.
BioCision Forms MedCision
The new company will focus on technologies for the management and automation of vital clinical processes.
Scroll Up
Scroll Down
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!