Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Researchers Grow Neural Blood Vessel Cells from Adult Stem Cells

Published: Monday, September 25, 2006
Last Updated: Monday, October 09, 2006
Bookmark and Share
Scientists develop adult stem cells from the blood of an mature animal that were able to be directed into specific cell types.

Scientists have predicted that embryonic stem cells might lead to cures for various diseases and conditions such as heart disease, Parkinson's or spinal cord injuries.

Now, a University of Missouri-Columbia researcher has isolated adult stem cells from blood that can be directed to turn into five types of cells, including bone, blood vessel and nerve cells.

The study is the cover article in the August edition of Stem Cells and Development

"Embryonic stem (ES) cells are able to give rise to the remarkable diversity of cell types that constitute a whole organism such as a human," said Elmer Price, a scientist at the MU Dalton Cardiovascular Research Center and associate professor of biomedical sciences in the College of Veterinary Medicine.

"However, this 'pluripotency,' or the ability of the cells to become anything, can also be a curse because ES cells can be misled by biochemical signals when they are transplanted into an adult during cell transplantation experiments."

"This often leads to the generation of unwanted cell types and, on occasion, tumor formation. Because of this, ES cell transplantation can raise serious safety issues."

"In this study, we developed adult stem cells from the blood of an mature animal that were able to be directed into specific cell types such as neurons and blood vessel cells, but they were not as pluripotent as ES cells. We have not observed any evidence of tumor formation."

Price extracted the adult stem cells from pigs' blood. These particular pig cells are unique because the pigs also contained a gene that makes their cells fluorescent.

This allowed Price to track the cells as they developed into nerve or blood vessel cells or upon transplantation.

The fluorescent pigs were created by MU animal scientist Randy Prather, who along with MU researcher Mike Foley, is a co-author of this paper.

In the study, Price was able to develop and sustain adult stem cell lines and then induce them to turn into specific cell types by exposing them to different chemical signals, depending on which type of cell he wanted to develop.

For adult stem cell transplantation therapy, different diseases will require different cell types.

Unlike embryonic stem cells, which are difficult to grow as pure cell populations and can develop into tumor-type tissue, Price's adult stem cells efficiently developed into specific cell types with no abnormal tissue.

"In theory, embryonic stem cells have the ability to become almost any cell type or organ," Price said.

"Very complex chemical signals need to be in place with embryonic stem cells in order for them to develop into the appropriate type of cell."

"However, we have shown that if you can isolate adult stem cells, you can make them generate the appropriate type of cell with much more ease and specificity."

"One day, we may be able to isolate similar adult stem cells from a patient, manipulate the cells in a petri dish, and then re-introduce them back into that same patient as a therapy."

The next step is to determine if enough cells can be produced with Price's method, as well as whether similar cells can be isolated from humans.

"We think that these blood-derived adult stem cells are normally used by the body for regeneration and repair, and we have been able to isolate these cells, grow them in a lab, and direct them toward a specific cell type for eventual therapeutic use," Price said.

"In humans, aging, chronic disease, and a lack of exercise may result in a lowered production of these cells, so it's important to lead a healthy lifestyle to maintain the body's own circulating population of stem cells."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 4,000+ scientific posters on ePosters
  • More Than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Salmonella as Alternative Treatment Option for Cancer
Scientists develop non-toxis Salmonella strain that target and breach cnacer cells.
Monday, October 31, 2016
50-Year-Old Bacteria Could Be Alternative Treatment Option for Cancer
Researchers have developed a non-toxic strain of Salmonella to penetrate and target cancer cells.
Friday, October 28, 2016
Creating Embryos with 'Heteroplasmy'
New discovery in genetic research could lead to treatments for mitochondrial diseases.
Wednesday, August 24, 2016
Fly Study into Therapies for HVP-Induced Cancer
Fruit flies may help scientists understand the mechanism by which HPV can cause cancer as well as identify potential drug treatments.
Monday, August 22, 2016
Bacteria Implicated in Reproductive Disorders
Bacteria harbored in the male reproductive system may be responsible for prostatitis.
Thursday, March 17, 2016
Researchers Discover A New Mechanism of Proteins to Block HIV
Certain IFITM proteins block and inhibit cell-to-cell transmission of HIV.
Tuesday, September 29, 2015
Scientists Successfully Edit Genes of Dengue Fever Mosquitoes
This research could lead to methods for preventing mosquito-borne diseases.
Monday, September 07, 2015
Unraveling the Elusive Structure of HIV Protein
Snapshots of HIV virus’ proteins may help design new ways to fight the disease.
Monday, July 06, 2015
Key Component in Protein that Causes Cystic Fibrosis Identified
Scientists hope that this finding may lay the foundations for the development of new medications and improved therapies.
Thursday, May 21, 2015
Green Tea Extract and Exercise Hinder Progress of Alzheimer’s
A study led by University of Missouri researchers has determined that a compound found in green tea, and voluntary exercise, slows the progression of the disease in mice and may actually reverse its effects.
Thursday, May 07, 2015
New Transitional Stem Cells Discovered
New stem cells are easier to manipulate, could help future research on reproductive problems.
Friday, April 17, 2015
MU Researchers Discover Protein's Ability To Inhibit HIV Release
TIM-family proteins have the ability to block the release of HIV and other viruses.
Wednesday, August 27, 2014
MU Scientists Successfully Transplant, Grow Stem Cells in Pigs
New line of pigs do not reject transplants, will allow for future research on stem cell therapies.
Saturday, June 07, 2014
Stem Cells Successfully Transplanted and Grown in Pigs
New line of pigs do not reject transplants, which will allow for future research on stem cell therapies.
Thursday, June 05, 2014
Adult Stem Cells Could Hold Key to Creating Cure for Type 1 Diabetes
Combining bone marrow cells with new drug restores insulin production.
Tuesday, June 04, 2013
Scientific News
Big Genetics in BC: The American Society for Human Genetics 2016 Meeting
Themes at this year's meeting ranged from the verification, validation, and sharing of data, to the translation of laboratory findings into actionable clinical results.
Stem Cells in Drug Discovery
Potential Source of Unlimited Human Test Cells, but Roadblocks Remain.
Automated Low Volume Dispensing Trends
Gain a better understanding of the current and future market requirements for fully automated LVD systems.
Cancer Genetics: Key to Diagnosis, Therapy
When applied judiciously, cancer genetics directs caregivers to the right drug at the right time, while sparing patients of unnecessary or harmful treatments.
Improved Stability, Shelf Life of Protein Drugs
Study improves protein drug stability and extend their shelf life by tested a novel route for non-covalent protein modification.
Plant Analysis – Identifying Metabolites
New plant analysis method shows biologically active plant substances are far more common than previously thought.
New Mechanism to Control Human Viral Infections Discovered
Researchers discover long sought after mechanism in human cells that could help treat diseases caused by viruses.
Biological Link between the Gut Microbiome and Parkinson’s Disease
The findings suggest that targeting the gut microbiome may provide a new approach for diagnosing and treating Parkinson’s disease.
Immune-Cell Traps May Aid Cancer Metastasis
Study suggests cancer cells can induce neutrophils to release traps which the cells use to capture pathogens.
Exploring the Genome of the River Blindness Parasite
Researchers have decoded the genome of the parasite that causes the skin and eye infection known as river blindness.
Scroll Up
Scroll Down
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
4,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!