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Expert Develops Nanoparticle Drug Delivery Method to Replace Eyedrops

Published: Friday, October 06, 2006
Last Updated: Friday, October 06, 2006
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The method uses biodegradable polymer nanoparticles to administer drugs to the eye.

Dr John Tsibouklis at the University of Portsmouth has announced that he has developed a nanoparticle drug delivery method, which uses biodegradable polymer nanoparticles to administer drugs to the eye.

Dr Tsibouklis said biodegradable polymers can be combined with drugs in such a way that the drug is released into the eye in a careful and controlled manner. The drug would have to be placed into the eye just once.

"The drug's release can be timed so it is constant, cyclic or triggered by an environmental or chemical signal, and the drug delivering polymer can be broken down naturally by the body when it is no longer needed," Dr Tsibouklis said.

People with eye conditions who use eye drops regularly would benefit from the biodegradable polymer drug delivery method.

Eye drops have many disadvantages- two main ones being the need to administer drops regularly and low ocular bioavailability (too little of the drug is getting to areas of the eye most in need).

The common alternative option to eye drops, ophthalmic inserts, achieve sustained drug delivery but suffer from limitations as- they are difficult to insert, easy to misapply and are expensive to manufacture.

Dr Tsibouklis said that the drug delivery systems hold significant promise for the pharmaceutical industry.

He describes the drug delivery systems in a paper, titled 'Polymeric materials for ophthalmic drug delivery: trends and perspectives' published in the Journal of Materials Chemistry.


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